Prometrium contains the female hormone progesterone, which plays an important role in maintaining the female reproductive system and regulating menstruation. Prometrium is prescribed to prevent endometrial hyperplasia, or a thickening of the uterine lining, in postmenopausal women who are receiving estrogen hormone replacement therapy. It is also used to restore menstrual periods in women whose periods have stopped, although they are not pregnant or going through menopause. The generic version of Prometrium is progesterone. The average retail price is about $1,838.34 for 90, 100mg capsules of Prometrium. You can lower your Prometrium cost by using a free Prometrium coupon from SingleCare at participating pharmacies in the United States. Pay as little as $32.45 for 90, 100mg capsules of generic Prometrium with a free SingleCare savings card.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 02/03/2026
Prometrium contains the female hormone progesterone, which plays an important role in maintaining the female reproductive system and regulating menstruation. Prometrium is prescribed to prevent endometrial hyperplasia, or a thickening of the uterine lining, in postmenopausal women who are receiving estrogen hormone replacement therapy. It is also used to restore menstrual periods in women whose periods have stopped, although they are not pregnant or going through menopause. The generic version of Prometrium is progesterone. The average retail price is about $1,838.34 for 90, 100mg capsules of Prometrium. You can lower your Prometrium cost by using a free Prometrium coupon from SingleCare at participating pharmacies in the United States. Pay as little as $32.45 for 90, 100mg capsules of generic Prometrium with a free SingleCare savings card.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Prometrium Retail Price | Progesterone Retail Price | Progesterone SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $1775.70 | $131.61 | $46.36 |
| Walmart | - | $68.40 | $64.80 |
| Walgreens | $1800.00 | $139.88 | $92.37 |
| Kroger Pharmacy | $1801.80 | $417.30 | $61.10 |
| Albertsons Pharmacy | - | $269.50 | $41.11 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Prometrium contains the female hormone progesterone, which plays an important role in maintaining the female reproductive system and regulating menstruation. Prometrium is prescribed to prevent endometrial hyperplasia, or a thickening of the uterine lining, in postmenopausal women who are receiving estrogen hormone replacement therapy. It is also used to restore menstrual periods in women whose periods have stopped, although they are not pregnant or going through menopause. The generic version of Prometrium is progesterone. The average retail price is about $1,838.34 for 90, 100mg capsules of Prometrium. You can lower your Prometrium cost by using a free Prometrium coupon from SingleCare at participating pharmacies in the United States. Pay as little as $32.45 for 90, 100mg capsules of generic Prometrium with a free SingleCare savings card.
Without insurance, the cash price for Prometrium is about $1,838.34 for 90, 100mg capsules of Prometrium. You can use a free SingleCare prescription discount card and save instantly on the pricing of your Prometrium prescription. With a SingleCare Prometrium discount card, you could pay the lowest price of $32.45 for 90, 100mg capsules of generic Prometrium at local pharmacies.
You can ask your pharmacist to help you calculate your Prometrium price with insurance since copays can vary depending on the health insurance plan. With SingleCare, Prometrium costs just $32.45 for 90, 100mg capsules of generic Prometrium, which could be more affordable than the cost with your insurance. Use a SingleCare Prometrium coupon at your local Walgreens or other pharmacies to compare retail prices and start saving today.
Some Medicare plans may cover the cost of Prometrium. The copay with Medicare will vary depending on the plan. For discounts on your Prometrium prescriptions, you could use a SingleCare prescription savings card and pay a reduced price of $32.45 for 90, 100mg capsules of generic Prometrium. You could also ask your pharmacist about the generic version of Prometrium, which may be cheaper than the brand-name drug and covered by Medicare.
Prometrium is a brand-name prescription medication manufactured by Virtus Pharmaceuticals. Progesterone is the generic version of Prometrium.
Prometrium is a female hormone that is prescribed as an adjunct treatment to reduce the risk of endometrial hyperplasia in postmenopausal women who are using estrogen replacement therapy. Endometrial hyperplasia is the thickening of the lining of the uterus that carries a risk of becoming cancerous. Prometrium is also used to restore normal menstruation in women who have stopped having periods although they are not pregnant or going through menopause. Prometrium is not meant to be used by children.
Do not use Prometrium if you are allergic to any of its ingredients. Prometrium should not be used to prevent heart disease or dementia. Studies have shown this medication may increase the risk of strokes, heart attacks, blood clots, and breast cancer. If you are pregnant, have unusual vaginal bleeding, a history of breast cancer, liver disease, or if you have recently had a heart attack, stroke, or blood clot, you should not use Prometrium.
Before using Prometrium, check with your doctor to ensure it is safe for you to use. If you have heart disease, migraines, asthma, seizures, or epilepsy, you need to tell your doctor. You also need to tell your doctor about all the medications you are using including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. Provide your doctor with a full medical history to reduce your risk of drug interactions and adverse effects.
Only use Prometrium as prescribed by your healthcare provider. Prometrium is taken as an oral tablet once a day at bedtime, or as directed by your doctor. Follow the dosing schedule carefully and ask your doctor if you have any questions. The dosage will be determined based on your medical condition and response to therapy.
Common side effects of Prometrium include fatigue, dizziness, headache, mood changes, constipation, diarrhea, nausea, vomiting, hot flashes, and vaginal discharge. Consult a healthcare provider if side effects occur, persist, or worsen.
If you have unusual vaginal bleeding, pain or burning when you urinate, a lump in your breast, sudden vision problems, severe headache, severe dizziness, or drowsiness, call your doctor right away. Serious adverse effects of Prometrium include heart attack, stroke, blood clots, and vision loss.
This is not a complete list of the possible side effects of Prometrium and more can occur. Ask your doctor about all the risks associated with using Prometrium to ensure it is right for you. You may also report side effects to the FDA. Talk to your doctor for additional information, medical advice, side effects, drug interactions, warnings, and precautions before starting treatment with Prometrium.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved