What is Propranolol-Hctz: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Propranolol-Hctz overview

BRAND NAMES:

Generic Names:

  • Propranolol-Hctz

Uses:

  • Treats high blood pressure. This medicine is a combination of a beta blocker and a diuretic (water pill).

Therapeutic Classes:

  • Beta-Adrenergic Blocker, Nonselective/Thiazide Combination

Forms:

  • Capsule, Tablet

How it’s taken:

  • By mouth

What is Propranolol-Hctz used for?

Propranolol-HCTZ is a thiazide-diuretic that comes in capsule form and is used to treat high blood pressure. It works by preventing the body from absorbing too much salt. You should not use this medicine if you have asthma or if you are unable to urinate. Common side effects may include diarrhea, constipation, upset stomach.

What form(s) does Propranolol-Hctz come in

  • Capsule

  • Tablet

What are common Propranolol-Hctz doses?

  • Tablet 40-25MG

  • Tablet 80-25MG

Common Propranolol-Hctz prescriptions

  • Propranolol-HCTZ
    40-25mg tablet

  • Propranolol-HCTZ
    80-25mg tablet

How to take Propranolol-Hctz

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • This medicine should not be the first medicine you use to treat your condition. It is meant to be used only after you have tried other medicines that have not worked or have caused unwanted side effects.

  • Oral routeCarefully follow your doctor's instructions about any special diet. Be sure to drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting. Check with your doctor right away if you continue to experience diarrhea or vomiting.

  • This medicine should not be the first medicine you use to treat your condition. It is meant to be used only after you have tried other medicines that have not worked or have caused unwanted side effects.

  • Oral routeCarefully follow your doctor's instructions about any special diet. Be sure to drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting. Check with your doctor right away if you continue to experience diarrhea or vomiting.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

What to do if you miss a dose of Propranolol-Hctz

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Oral routeAsk your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Propranolol-Hctz contraindications

  • You should not use this medicine if you have had an allergic reaction to propranolol, hydrochlorothiazide, sulfa drugs (such as sulfamethoxazole, Bactrim®, Septra®), or certain blood pressure medicines (such as atenolol, metoprolol, Tenormin®). You should not use this medicine if you are not able to form urine (anuria), or if you have asthma or certain heart problems. Talk with your doctor about what these heart problems are.

Propranolol-Hctz warnings

  • Check with your doctor right away if you start having dry mouth, increased thirst, muscle cramps, nausea or vomiting, unusual tiredness or weakness, severe drowsiness or dizziness, seizures, a decrease in urine, or a fast heartbeat while you are using this medicine. These may be symptoms of dehydration or mineral imbalance.

  • Stop using this medicine and check with your doctor immediately if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. This could be a sign of a serious eye problem. Your doctor will want you to have your eyes checked by an eye doctor.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • If you stop using this medicine, your blood pressure may go up. High blood pressure usually has no symptoms. Even if you feel well, do not stop using the medicine without asking your doctor.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Blood and urine tests may be needed to check for unwanted effects.

  • Unusual tiredness or weakness.

  • Yellowing of your skin or the whites of your eyes.

  • This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

  • Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin; red skin lesions; severe acne or skin rash; sores or ulcers on the skin; or fever or chills while you are using this medicine.

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, blood vessel disorders, chest pain (angina), congestive heart failure, circulation problems, or a history of mineral imbalance (such as high or low calcium, magnesium, potassium, or sodium in the blood). Tell your doctor if you have diabetes, gout, lung problems, lupus, overactive thyroid, or Wolff-Parkinson-White syndrome.

  • This medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life.

  • This medicine may cause serious allergic reactions including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, lips, tongue, or throat while you are using this medicine.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • This medicine may cause heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort; dilated neck veins; extreme fatigue; irregular breathing; an irregular heartbeat; shortness of breath; swelling of the face, fingers, feet, or lower legs; weight gain; or wheezing.

Propranolol-Hctz interactions

  • Make sure your doctor knows if you are also using amiodarone (Cordarone®), clonidine (Catapres®, Combipres®), deserpidine (Dureticyl®, Harmonyl®), digoxin (Lanoxin®), epinephrine (Epi-Pen®), fentanyl (Actiq®, Duragesic®), haloperidol (Haldol®), ketanserin (Sufrexal®), lithium (Eskalith®, Lithobid®), reserpine (Ser-ap-es®), thioridazine (Mellaril®), verapamil (Calan®, Covera®, Isoptin®), pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, Advil®, Aleve®, Motrin®, or Orudis®), or a steroid medicine (such as cortisone, prednisone, Azmacort®, Flonase®, or Medrol®).

  • Tell your doctor if you are also using aluminum hydroxide gel (Amphojel®), antipyrine, chlorpromazine (Thorazine®), cimetidine (Tagamet®), insulin, lidocaine (Xylocaine®), norepinephrine, phenobarbitone, phenytoin (Dilantin®), rifampin (Rifadin®, Rimactane®), theophylline (Theo-Dur®), thyroxine, or tubocurarine.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

  • Do not use medicines, supplements, or salt substitutes that contain potassium without checking first with your doctor.

  • Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin; red skin lesions; severe acne or skin rash; sores or ulcers on the skin; or fever or chills while you are using this medicine.

  • Do not drink alcohol while you are using this medicine.

  • Check with your doctor right away if you start having dry mouth, increased thirst, muscle cramps, nausea or vomiting, unusual tiredness or weakness, severe drowsiness or dizziness, seizures, a decrease in urine, or a fast heartbeat while you are using this medicine. These may be symptoms of dehydration or mineral imbalance.

  • This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

  • Stop using this medicine and check with your doctor immediately if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. This could be a sign of a serious eye problem. Your doctor will want you to have your eyes checked by an eye doctor.

  • If you stop using this medicine, your blood pressure may go up. High blood pressure usually has no symptoms. Even if you feel well, do not stop using the medicine without asking your doctor.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Blood and urine tests may be needed to check for unwanted effects.

Propranolol-Hctz side effects

Serious Side Effects

  • Seizures.

  • Change in how much or how often you urinate.

  • Dry mouth, increased thirst, muscle cramps, nausea, or vomiting.

  • Unusual tiredness or weakness.

  • Chest pain (may be related to your disease and not a side effect).

  • Fast, slow, or uneven heartbeat.

  • Yellowing of your skin or the whites of your eyes.

  • Shortness of breath, cold sweat, and bluish-colored skin.

  • Confusion, body weakness, or muscle twitching.

  • Lightheadedness, dizziness, or fainting.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, or red skin rash.

  • Blurred vision or changes in vision.

  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.

  • Swelling in your hands, ankles, or feet.

Less Serious Side Effects

  • Loss of appetite.

  • Mild skin rash.

  • Diarrhea or constipation.