What is Renagel: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Renagel overview

BRAND NAMES:

  • Renagel, Renvela, Sevelamer Carbonate

Generic Names:

  • Sevelamer Hcl

Uses:

  • Lowers the amount of phosphorus in blood of patients receiving kidney dialysis.

Therapeutic Classes:

  • Phosphate Binder

Forms:

  • Liquid, Tablet

How it’s taken:

  • By mouth

What is Renagel used for?

What form(s) does Renagel come in

  • Liquid

  • Tablet

What are common Renagel doses?

  • Tablet 800MG

Common Renagel prescriptions

  • Renagel
    100 tablets bottle

  • Renagel
    90 tablets bottle

  • Renagel
    400mg tablet

  • Renagel
    800mg tablet

How to take Renagel

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Oral routeIt is best to take this medicine with food or milk.

  • Oral liquid: Mix the entire contents of the packet with 2 tablespoons of water for the 0.4-gram dose or the 0.8-gram dose or 4 tablespoons of water for the 2.4-gram dose. Stir the mixture well just before you drink it. You should drink the medicine within 30 minutes of mixing it.

  • Your doctor may tell you to take vitamins D, E, and K and folic acid supplements during treatment with this medicine, especially if you are pregnant.

  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Oral liquid: Mix the entire contents of the packet with 2 tablespoons of water for the 0.4-gram dose or the 0.8-gram dose or 4 tablespoons of water for the 2.4-gram dose. Stir the mixture well just before you drink it. You should drink the medicine within 30 minutes of mixing it.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Oral routeIt is best to take this medicine with food or milk.

  • Your doctor may tell you to take vitamins D, E, and K and folic acid supplements during treatment with this medicine, especially if you are pregnant.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

What to do if you miss a dose of Renagel

Renagel contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to sevelamer, or if you have a bowel blockage.

Renagel warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have problems swallowing, stomach or bowel problems (including chronic constipation), or had surgery on your digestive system.

  • This medicine may cause serious stomach or bowel problems, including blockage, bleeding, ulcers, colitis (severe diarrhea), necrosis, or perforation (tear or hole).

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Severe stomach pain, cramping, or burning

  • Vomiting of material that looks like coffee grounds

Renagel interactions

  • Take mycophenolate mofetil at least 2 hours before this medicine.

  • Some medicines can affect how sevelamer works. Tell your doctor if you are using any of the following:Cyclosporine, levothyroxine, tacrolimus

  • If you are taking any other medicines, you may be asked to take them at least 1 hour before or 3 hours after you take sevelamer. If you need help deciding the best times to take your other medicines, ask your doctor or pharmacist.

  • Take ciprofloxacin at least 2 hours before or 6 hours after this medicine.

Renagel side effects

Serious Side Effects

  • Fever, chills

  • Vomiting of material that looks like coffee grounds

  • Stomach pain, cramping, or burning

  • Constipation, diarrhea, nausea, vomiting

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Red or black stools

Less Serious Side Effects

  • Passing gas, stomach upset

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