What is Sulfadiazine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Sulfadiazine overview

BRAND NAMES:

Generic Names:

  • Sulfadiazine

Uses:

  • Treats many different kinds of infections such as urinary tract infections, malaria, certain ear infections, and toxoplasmosis. Is also used to help prevent rheumatic fever or meningitis.Belongs to the "sulfa" class of drugs.

Therapeutic Classes:

  • Antibiotic

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Sulfadiazine used for?

What form(s) does Sulfadiazine come in

  • Tablet

What are common Sulfadiazine doses?

  • Tablet 500MG

Common Sulfadiazine prescriptions

  • sulfADIAZINE
    500mg tablet

How to take Sulfadiazine

  • Keep taking this medicine for as long as your doctor ordered. If you stop taking the medicine too soon, your infection may not completely go away.

  • Swallow with a full glass (8 ounces) of water. Drink several extra glasses of water every day while taking this medicine.

  • Your doctor will tell you how much medicine to take and how often.

  • Swallow with a full glass (8 ounces) of water. Drink several extra glasses of water every day while taking this medicine.

  • Your doctor will tell you how much medicine to take and how often.

  • Keep taking this medicine for as long as your doctor ordered. If you stop taking the medicine too soon, your infection may not completely go away.

What to do if you miss a dose of Sulfadiazine

  • You should not use two doses at the same time.

  • Take the missed dose as soon as possible, unless it is almost time for your next dose.

  • Skip the missed dose if it is almost time for your next regular dose.

Sulfadiazine contraindications

  • You should not use this medicine if you have had an allergic reaction to any sulfa drug. You should not use this medicine if you are breastfeeding, or if you are in the last 3 months of a pregnancy. Do not give this medicine to a baby who is not under the care of a doctor.

Sulfadiazine warnings

  • While you are taking this medicine, your doctor may want to check your blood at regular intervals. Be sure to keep all schedule appointments.

  • If you are in the early months of a pregnancy, talk with your doctor before taking this medicine. Sulfadiazine should not be taken during the last 3 months of a pregnancy.

  • Before taking sulfadiazine tell your doctor if you have anemia or other blood problems, asthma or severe allergies, liver disease, kidney disease, G-6-PD (glucose-6-phosphate dehydrogenase) deficiency.

  • Unexplained fever, chills, or sore throat

  • Unusual bruising or bleeding, purple spots on your skin

  • Wheezing, trouble breathing, or trouble swallowing

  • Yellowing of skin or eyes

Sulfadiazine interactions

  • While you are taking this medicine, your doctor may want to check your blood at regular intervals. Be sure to keep all schedule appointments.

  • Make sure your doctor knows if you are also taking aspirin, indomethacin (Indocin®), probenecid (Benemid®), Coumadin® or other blood thinners, a diuretic (water pill), methotrexate, phenytoin (Dilantin®), or diabetes medicine (such as Diabenese®, Glucotrol®, DiaBeta®, Micronase®, or Tolinase®).

  • If you are in the early months of a pregnancy, talk with your doctor before taking this medicine. Sulfadiazine should not be taken during the last 3 months of a pregnancy.

Sulfadiazine side effects

Serious Side Effects

  • Unusual bruising or bleeding, purple spots on your skin

  • Unexplained fever, chills, or sore throat

  • Blistering or peeling skin

  • Skin rash, hives, or itching

  • Swelling in your face, lips, or throat

  • Yellowing of skin or eyes

  • Wheezing, trouble breathing, or trouble swallowing

Less Serious Side Effects

  • Headache

  • Diarrhea

  • Appetite loss, nausea, upset stomach

Subscribe to our savings newsletter

Health education, drug info, wellness & more

By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.