Sulfamylon is a prescription topical antibiotic that prevents infection of second- and third-degree burns as well as skin grafts. Sulfamylon is applied as a cream or solution. The active ingredient in Sulfamylon is mafenide acetate, a sulfa drug that prevents bacteria from reproducing. Sulfamylon is usually administered by a healthcare professional but may also be purchased at pharmacies. Currently, Sulfamylon costs $95.32. A SingleCare Sulfamylon coupon reduces the price of Sulfamylon to $72.84 at participating pharmacies, such as CVS, Target, and Longs Drugs, among others.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Sulfamylon is a prescription topical antibiotic that prevents infection of second- and third-degree burns as well as skin grafts. Sulfamylon is applied as a cream or solution. The active ingredient in Sulfamylon is mafenide acetate, a sulfa drug that prevents bacteria from reproducing. Sulfamylon is usually administered by a healthcare professional but may also be purchased at pharmacies. Currently, Sulfamylon costs $95.32. A SingleCare Sulfamylon coupon reduces the price of Sulfamylon to $72.84 at participating pharmacies, such as CVS, Target, and Longs Drugs, among others.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Sulfamylon Retail Price | Sulfamylon SingleCare Price |
|---|---|---|
| Walgreens | $86.75 | $79.38 |
| Kroger Pharmacy | $86.75 | $75.98 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Sulfamylon is a prescription topical antibiotic that prevents infection of second- and third-degree burns as well as skin grafts. Sulfamylon is applied as a cream or solution. The active ingredient in Sulfamylon is mafenide acetate, a sulfa drug that prevents bacteria from reproducing. Sulfamylon is usually administered by a healthcare professional but may also be purchased at pharmacies. Currently, Sulfamylon costs $95.32. A SingleCare Sulfamylon coupon reduces the price of Sulfamylon to $72.84 at participating pharmacies, such as CVS, Target, and Longs Drugs, among others.
The price for Sulfamylon without insurance averages around $95.32 per 1, 56.7gm of 85mg/gm tube of cream, but this price may vary. Sulfamylon is often applied by a healthcare professional and billed by the clinic or hospital where it is applied, so the price can vary dramatically from the pharmacy price. With a SingleCare Sulfamylon discount card, a prescription for 1, 56.7gm of 85mg/gm tube of cream of Sulfamylon costs $72.84.
The copay cost for Sulfamylon will vary. It is often applied in an emergency or clinical setting by a healthcare professional, so the cost may be covered by health insurance. Purchased at a pharmacy, the copay cost will vary depending on the insurance plan. You can ask your pharmacist to compare your copay cost to your price using a SingleCare discount card. You might save more by using SingleCare.
Medicare prescription drug plans do not cover Sulfamylon prescriptions.
For Medicare patients with a prescription for Sulfamylon, you’ll pay as little as $72.84 for 1, 56.7gm of 85mg/gm tube of cream of Sulfamylon with a SingleCare Sulfamylon at participating pharmacies.
Sulfamylon is a brand-name topical antibiotic (mafenide acetate) for serious burns and skin grafts. It is available as a powder (for reconstitution in sterile water) and a cream. Generic mafenide acetate is available as a powder for reconstitution and is covered by most Medicare prescription drug plans. There are no generic mafenide acetate creams. Search the SingleCare website to find coupons for mafenide acetate as well as more information.
Sulfamylon is an over-the-counter topical antibiotic that prevents bacterial infection serious burns (second- and third-degree) and skin grafts. The active ingredient in Sulfamylon, mafenide acetate, belongs to a class of antibiotics called sulfa drugs. These drugs interfere with the bacteria's ability to use folate to make copies of its DNA and produce new bacteria cells.
Sulfamylon is available as a cream or powder for reconstitution. The cream can be found at pharmacies and is used for the home care of serious burns. The powder is more frequently used by healthcare professionals in an emergency or clinical setting. It is reconstituted in sterile water and used to keep wound dressings wet either using irrigation tubing or a syringe.
Some but not all common side effects of Sulfamylon are primarily site reactions and include skin redness, itching, rash, blistering, burning, or pain. Acidosis (too much acid in the blood) frequently results from the prolonged use of mafenide acetate on burns. Healthcare providers will discontinue the use of Sulfamylon for one or two days to help restore normal acid-base levels in the blood. Allergic reactions to sulfa drugs are common. Again, healthcare providers will discontinue Sulfamylon when they notice signs of an allergic reaction such as hives, facial swelling, or trouble breathing.
These are not all the possible side effects of Sulfamylon. Always consult with your physician or pharmacist if you have any worries or questions about possible side effects.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved