Sustiva
Efavirenz
Treats HIV infection. HIV causes AIDS. This medicine does not cure HIV or AIDS, but combinations of drugs may slow the progress of the disease.
Antiretroviral Agent
Capsule, Tablet
By mouth
Capsule
Tablet
Tablet 600MG
Capsule 50MG
Capsule 200MG
Sustiva
200mg capsule
Sustiva
50mg capsule
Sustiva
600mg tablet
Your doctor will tell you how much medicine to use. Do not use more than directed.
Take all other medicines your doctor has prescribed as part of your combination treatment.
Do not stop using this medicine without talking to your doctor first. If you stop the medicine, even for a short time, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.
Take this medicine on an empty stomach, preferably at bedtime. Swallow the capsule or tablet whole with water. Do not break, crush, or chew the tablet.
If you cannot swallow the capsule whole:You may open the capsule and pour the contents into 1 to 2 teaspoons of soft food (such as applesauce, grape jelly, or yogurt). You may also mix the medicine into an infant's formula.Swallow the mixture within 30 minutes. Give the formula/medicine mixture with an oral dosing syringe.After you swallow the mixture, add a small amount of food (or formula) into the empty container and gently stir. Swallow this mixture, too, to make sure you get all of the medicine that was in the capsule.Do not eat anything else for 2 hours after taking this medicine mixed with food or formula.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
If you cannot swallow the capsule whole:You may open the capsule and pour the contents into 1 to 2 teaspoons of soft food (such as applesauce, grape jelly, or yogurt). You may also mix the medicine into an infant's formula.Swallow the mixture within 30 minutes. Give the formula/medicine mixture with an oral dosing syringe.After you swallow the mixture, add a small amount of food (or formula) into the empty container and gently stir. Swallow this mixture, too, to make sure you get all of the medicine that was in the capsule.Do not eat anything else for 2 hours after taking this medicine mixed with food or formula.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Take all other medicines your doctor has prescribed as part of your combination treatment.
Do not stop using this medicine without talking to your doctor first. If you stop the medicine, even for a short time, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Take this medicine on an empty stomach, preferably at bedtime. Swallow the capsule or tablet whole with water. Do not break, crush, or chew the tablet.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Your doctor will tell you how much medicine to use. Do not use more than directed.
This medicine is not right for everyone. Do not use it if you had an allergic reaction to efavirenz, or if you are pregnant.
This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use 2 forms of birth control during your treatment time and for at least 12 weeks after your last dose. Birth control pills may not work while you are using efavirenz, so do not use a hormone method as a form of birth control. Use a barrier method plus another type. Talk with your doctor about what choice is best for you.
Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.
Tell your doctor if you have heart disease or a history of liver disease (including hepatitis B or C), seizures, mental illness, or drug abuse.
This medicine may cause the following problems:Heart rhythm problems, including QT prolongationUnusual changes in mood or behaviorSevere liver problemsSevere skin rashIncreased cholesterol levelChanges in body fat
Your immune system may get stronger when you start taking an HIV medicine. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.
This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Do not take Atripla® while you are being treated with this medicine, unless your doctor tells you to. Atripla® also has efavirenz in it.
The list below includes some of the medicines that can interact with efavirenz. There are other drugs not listed. Make sure your doctor knows all of the medicines you use.Artemether/lumefantrine, atorvastatin, atovaquone/proguanil, boceprevir, bupropion, carbamazepine, clarithromycin, cyclosporine, itraconazole, ketoconazole, methadone, phenobarbital, phenytoin, posaconazole, pravastatin, rifabutin, rifampin, sertraline, simeprevir, simvastatin, sirolimus, tacrolimus, or voriconazoleBirth control pill or implantBlood pressure medicineBlood thinner (including warfarin)Other medicine to treat HIV/AIDS
Alcohol, narcotic pain medicine, sleeping pills, and similar medicines may cause you to feel more lightheaded, dizzy, or faint when used together with this medicine.
This medicine may cause the following problems:Severe liver problemsSevere skin rashIncreased cholesterol levelChanges in body fat
Your immune system may get stronger when you start taking an HIV medicine. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.
This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.
Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Serious Side Effects
Severe sleepiness, decreased awareness or responsiveness
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Fast, pounding, or uneven heartbeat
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Anxiety, anger, aggression, severe depression, seeing or hearing things that are not there, or thoughts of hurting yourself or others
Behavior or mood changes , paranoid or manic behavior
Blistering, peeling, red skin rash
Seizures
Less Serious Side Effects
Headache
Trouble sleeping or concentrating, strange dreams
Weight gain around your neck, upper back, breast, face, or waist
Dizziness, drowsiness, tiredness
Health education, drug info, wellness & more
SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2026 SingleCare Administrators. All rights reserved
© 2026 SingleCare Administrators. All rights reserved