Sertraline is a generic prescription drug used to treat major depressive disorder and other mental health disorders. Sertraline is an antidepressant that is classified as a selective serotonin reuptake inhibitor (SSRI). It may help relieve symptoms of depression by affecting the levels and activity of serotonin in the brain. Sertraline is a generic drug that is known by the brand name Zoloft. On average, the retail price of Sertraline is $73.82 for 30, 50mg tablets. However, it could cost $8.72 for 30, 50mg tablets with a SingleCare Sertraline coupon at participating pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Sertraline is a generic prescription drug used to treat major depressive disorder and other mental health disorders. Sertraline is an antidepressant that is classified as a selective serotonin reuptake inhibitor (SSRI). It may help relieve symptoms of depression by affecting the levels and activity of serotonin in the brain. Sertraline is a generic drug that is known by the brand name Zoloft. On average, the retail price of Sertraline is $73.82 for 30, 50mg tablets. However, it could cost $8.72 for 30, 50mg tablets with a SingleCare Sertraline coupon at participating pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Zoloft Retail Price | Sertraline Hcl Retail Price | Sertraline Hcl SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $528.90 | $34.95 | $33.86 |
| Walmart | $520.50 | $14.10 | $13.80 |
| Walgreens | $533.10 | $39.90 | $28.49 |
| Kroger Pharmacy | $550.50 | $33.72 | $11.20 |
| Albertsons Pharmacy | - | $61.90 | $14.29 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Sertraline is a generic prescription drug used to treat major depressive disorder and other mental health disorders. Sertraline is an antidepressant that is classified as a selective serotonin reuptake inhibitor (SSRI). It may help relieve symptoms of depression by affecting the levels and activity of serotonin in the brain. Sertraline is a generic drug that is known by the brand name Zoloft. On average, the retail price of Sertraline is $73.82 for 30, 50mg tablets. However, it could cost $8.72 for 30, 50mg tablets with a SingleCare Sertraline coupon at participating pharmacies.
A usual supply for Sertraline costs an average cash price of $73.82 for 30, 50mg tablets. The cost of Sertraline without insurance can vary depending on various factors, such as the pharmacy location and the strength or quantity prescribed. With a SingleCare Sertraline coupon, you could save on the cash price of the medication. You may be able to pay $8.72 for 30, 50mg tablets with a prescription discount card at participating pharmacies.
Your copay for Sertraline will vary depending on your insurance plan, coverage stage, and the prescribed dosage. Contact your insurance company or pharmacist to determine your cost of Sertraline with insurance. In some cases, paying cash with a prescription discount card could save you more than you would with insurance. Compare the cost of Sertraline with insurance to the cost with a SingleCare.
Medicare insurance plans generally help cover the cost of Sertraline. The copay or coinsurance amount with Medicare Part D and Medicare Advantage plans can vary. It’s best to consult your insurance plan or pharmacist to find out if Sertraline is covered. If you have to meet your deductible, you may have to pay the full cash price of the drug.
Sertraline is a generic prescription drug. The brand name of Sertraline is Zoloft, which is manufactured by Pfizer. Various drug manufacturers produce the generic version of Zoloft, including Lupin, Aurobindo, and Ascent Pharmaceuticals.
Sertraline is a generic prescription drug used to treat moderate to severe depression and other psychiatric disorders. In addition to depression, Sertraline can be prescribed to treat panic disorder, a condition in which a person experiences recurrent panic attacks. Sertraline is also approved to treat obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), social anxiety disorder (SAD), and premenstrual dysphoric disorder (PMDD). It is commonly used off-label to treat other mental health conditions.
Sertraline belongs to a class of drugs called SSRIs (selective serotonin reuptake inhibitors). These drugs work by increasing serotonin levels in the brain, which may help improve symptoms of depression and other mental health conditions.
Sertraline is usually prescribed to be taken as an oral tablet once daily. The dosage can vary depending on the condition being treated. Consult a healthcare provider for medical advice and additional information about how Sertraline may work for you.
The most common side effects of Sertraline include:
Nausea
Loss of appetite
Dizziness or lightheadedness
Dry mouth
Diarrhea
Indigestion
Drowsiness
Insomnia
Increased sweating
Tremor
Agitation
Fatigue
Anxiety
Decreased sexual desire (libido)
Ejaculatory or erection problems
Side effects of Sertraline are more likely to occur during the first week or two of treatment. These side effects are usually mild and temporary and often go away as the body gets used to the medication.
Serious side effects of Sertraline include suicidal thoughts or behaviors, serotonin syndrome, increased risk of bleeding, manic episodes, seizures, angle-closure glaucoma, low blood sugar, irregular heartbeats, and low sodium levels in the blood. An allergic reaction to Sertraline is also possible. Seek immediate medical attention if you experience symptoms of an allergic reaction, such as hives, itching, swelling of the face or throat, or trouble breathing.
Do not stop taking Sertraline abruptly. Discontinuing the use of Sertraline may lead to withdrawal symptoms, such as anxiety, headache, dizziness, and irritability.
This is not a complete list of side effects. Consult a doctor or healthcare provider for other possible side effects before starting treatment with Sertraline.
Weight changes, such as weight loss or weight gain, are possible side effects of Sertraline. However, weight changes are more common in children and adolescents than adults. Clinical trials have shown that children and adolescents taking Sertraline may experience weight loss or weight gain. Monitoring weight changes, growth, and development in children or adolescents taking Sertraline is recommended.
Some people may experience improved symptoms after taking Sertraline for one to two weeks. However, for other people, it can take up to six or eight weeks to experience the maximum effects of Sertraline. Talk to a healthcare provider before stopping the use of Sertraline, especially if you feel you are not experiencing improved symptoms after this timeline.
Anne Jacobson, MD, MPH, is a board-certified family physician, writer, editor, teacher, and consultant. She is a graduate of University of Wisconsin School of Medicine and Public Health, and trained at West Suburban Family Medicine in Oak Park, Illinois. She later completed a fellowship in community medicine at PCC Community Wellness and a master's in Public Health at the University of Illinois-Chicago. She lives with her family near Chicago.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved