What is Tri-Luma? Uses, warnings & side effects

Follow all the prescriber’s instructions.

Do not use more of this cream than prescribed. Do not use it more frequently than prescribed.

Please read the Patient Information sheet that comes with this medicine.

Do not use Tri-Luma to treat any other dark spots that are not caused by melasma.

To apply Tri-Luma cream:

• Gently wash your face with a mild cleanser.

• Rinse and dry your face.

• Apply a thin layer to the affected skin. Also, cover the skin around the dark spot to a distance of ½ inch.

• Gently rub the cream evenly into the skin.

• Do not use cream on the corner of the mouth, the nose, eyes, or open wounds.

• Do not cover the treated skin after applying the cream.

Store Tri-Luma cream in a refrigerator. Do not freeze. The tube should be tightly closed.

Ask the prescriber how to manage a missed dose.

This medicine should be used at night.

Do not apply two doses to make up for a missed dose.

This medicine is not right for everyone.

Do not use this medicine if you have had an allergic reaction to fluocinolone, hydroquinone, or tretinoin.

The prescriber may need to check on the progress of this treatment. Keep all appointments.

Tell other healthcare providers who treat you that you are using Tri-Luma.

Tell the prescriber if you are pregnant, breastfeeding, or have:

• Allergies to sulfites

• Any other medical condition

This medicine may cause a blue-black discoloration of the skin. Check with the prescriber right away if you have a gradual darkening of the skin.

This medicine may make your skin more sensitive to sunlight, wind, and cold weather. 

• Avoid sunlamps and tanning beds. 

• Use sunscreen with a sun protection factor of SPF 30 or higher during the day. 

• Wear protective clothing, such as a hat, when you are outdoors.

Avoid cleansers or cosmetics that may dry or irritate your skin. Use a moisturizer as needed.

This medication may cause serious side effects if it’s absorbed into the bloodstream. These include:

• Adrenal gland dysfunction

• Cushing’s syndrome (due to high corticosteroid levels)

• High blood sugar

Tri-Luma is not intended for long-term or continuous use.

Tri-Luma may not be effective in people with brown or dark skin.

To avoid possible drug interactions, tell the prescriber about all the medications you take or plan to take, particularly:

• Other corticosteroids

• Hormonal birth control

• Photosensitizing drugs (such as for psoriasis)

• Other drugs that cause photosensitivity such as quinolone antibiotics (like ciprofloxacin)

Do not take birth control pills while using Tri-Luma. They can worsen melasma.

Do not put cosmetics or skin care products on the treated skin. 

Avoid using medicated, irritating, or drying soaps or cleansers on the area being treated.