What is Trimipramine Maleate: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Trimipramine Maleate overview

BRAND NAMES:

  • Surmontil

Generic Names:

  • Trimipramine Maleate

Uses:

  • Treats depression. This medicine is a tricyclic antidepressant (TCA).

Therapeutic Classes:

  • Antidepressant

Forms:

  • Capsule, Tablet

How it’s taken:

  • By mouth

What is Trimipramine Maleate used for?

Surmontil is an oral antidepressant used to treat depression. It changes the unbalanced chemicals (neurotransmitters) in the brain to make them balanced. This action improves mood and sense of well-being.

What form(s) does Trimipramine Maleate come in

  • Capsule

  • Tablet

What are common Trimipramine Maleate doses?

  • Capsule 25MG

  • Capsule 50MG

  • Capsule 100MG

Common Trimipramine Maleate prescriptions

  • Trimipramine Maleate
    100mg capsule

  • Trimipramine Maleate
    25mg capsule

  • Trimipramine Maleate
    50mg capsule

How to take Trimipramine Maleate

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Your doctor may tell you to take this medicine at bedtime, because it can make you sleepy.

  • You may need to take this medicine for a month or longer before you feel better.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • You may need to take this medicine for a month or longer before you feel better.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Your doctor may tell you to take this medicine at bedtime, because it can make you sleepy.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

What to do if you miss a dose of Trimipramine Maleate

Trimipramine Maleate contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to trimipramine or similar medicines, or you recently had a heart attack.

Trimipramine Maleate warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, glaucoma, heart or blood vessel disease, schizophrenia, thyroid problems, or a history of mania, seizures, or trouble urinating.

  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.

  • This medicine may cause the following problems:Serotonin syndrome (more likely when used with certain other medicines)Changes in blood sugar levels

  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Trimipramine Maleate interactions

  • Do not use this medicine and an MAO inhibitor (MAOI) within 14 days of each other.

  • Do not drink alcohol while you are using this medicine.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

  • Some medicines can affect how trimipramine works. Tell your doctor if you are using the following: Atropine, buspirone, cimetidine, fentanyl, guanethidine, lithium, tramadol, St John's wortThyroid medicine, tryptophan supplements, triptan medicine for migraine medicines, medicine for heart rhythm problems (such as flecainide, propafenone, quinidine), other medicine to treat depression (such as fluoxetine, paroxetine, sertraline), or a phenothiazine medicine (such as chlorpromazine, perphenazine, promethazine, prochlorperazine, thioridazine)

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Trimipramine Maleate side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Agitation, restlessness, mood or mental changes, trouble sleeping

  • Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there

  • Seizures

  • Fast, slow, pounding, or uneven heartbeat

  • Thoughts of hurting yourself or others, unusual behavior

  • Chest pain, trouble breathing

Less Serious Side Effects

  • Eye pain, vision changes, seeing halos around lights

  • Dry mouth

  • Drowsiness or dizziness

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