What is Xadago: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Jun 17, 2021

Xadago overview

BRAND NAMES:

  • Xadago

Generic Names:

  • Xadago

Uses:

  • Treats Parkinson's disease in patients who are having "off" episodes.

Therapeutic Classes:

  • Antiparkinsonian

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Xadago used for?

What form(s) does Xadago come in

  • Tablet

What are common Xadago doses?

  • Tablet 50MG

  • Tablet 100MG

Common Xadago prescriptions

  • Xadago
    100mg tablet

  • Xadago
    50mg tablet

How to take Xadago

  • Missed dose: If you missed a dose, take the next dose at the same time the next day.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Take this medicine at the same time each day.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

What to do if you miss a dose of Xadago

Xadago contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to safinamide.

Xadago warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver problems, dyskinesia, high blood pressure, or a history of eye or vision problems or mental health problems.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • This medicine may cause the following problems:High blood pressureSerotonin syndrome (when used with other medicines)Dyskinesia (trouble controlling movements)Unusual changes in behavior, compulsive behavior, hallucinations

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • This medicine may make you drowsy. It may even cause you to fall asleep without warning while you are driving or doing other activities. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Stand up slowly if you feel dizzy or lightheaded.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

Xadago interactions

  • Do not take safinamide if you are also using amphetamine, cyclobenzaprine, dextromethorphan, methylphenidate, St John's wort, other MAO inhibitors (including linezolid), narcotic pain medicines (including meperidine, methadone, propoxyphene, tramadol), or medicine to treat depression (including amitriptyline, desvenlafaxine, duloxetine, milnacipran, nortriptyline, venlafaxine).

  • Some foods and medicines can affect how safinamide works. Tell your doctor if you are using any of the following:Imatinib, irinotecan, isoniazid, lapatinib, methotrexate, metoclopramide, mitoxantrone, rosuvastatin, sulfasalazine, or topotecanMedicines for colds, cough, hay fever, or sinus problems

  • Avoid foods and drinks that are high in tyramine, because your blood pressure could get dangerously high. Your doctor should give you a complete list. In general, do not eat anything aged or fermented, such as most cheese, most alcohol, cured meat (such as salami), sauerkraut, and soy sauce. Check the expiration dates on packages. Tyramine levels get higher as food gets older or if it has not been refrigerated properly.

Xadago side effects

Serious Side Effects

  • Anxiety, restlessness, fever, sweating, nausea, vomiting, diarrhea, seeing or hearing things that are not there

  • Lightheadedness, dizziness, fainting

  • Blurred vision, change in vision

  • Muscle spasms, twitching, uncontrolled movements (especially of the face, neck, or back)

  • Chest pain, fast, slow, or uneven heartbeat, severe headache

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Unusual drowsiness or sleepiness

  • Confusion, unusual changes in mood or behavior, behaviors you cannot control

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