What is Xrylix: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Sep 24, 2021

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Xrylix overview

BRAND NAMES:

  • Diclofono, Diclo Gel, Diclozor, Klofensaid II, Lexixryl, Pennsaid, Solaravix, Solaraze, Voltaren Gel, Xrylix, DST Plus Pak, Inflamma-K, Lorvatus

Generic Names:

  • Xrylix

Uses:

  • Treats actinic keratoses. Also treats pain and swelling caused by arthritis. This is an NSAID.

Therapeutic Classes:

  • Analgesic, Anti-Inflammatory

Forms:

  • Gel/Jelly, Liquid

How it’s taken:

  • On the skin

What is Xrylix used for?

What form(s) does Xrylix come in

  • Gel/Jelly

  • Liquid

What are common Xrylix doses?

  • Box 1 Therapy Pack

Common Xrylix prescriptions

  • Xrylix
    1 therapy pack box

How to take Xrylix

  • Use your medicine as directed. There are several brands of this medicine. Make sure you understand how to use the brand you have been prescribed. Ask your doctor if you have any questions.

  • The Voltaren® gel comes with a dosing card to measure the correct dose. If you do not receive or misplace your dosing card, call your pharmacist to ask for a new one.

  • Topical application routeUse this medicine only on your skin. Rinse it off right away if it gets on a cut or scrape. Do not get the medicine in your eyes, nose, or mouth.

  • Topical application routeWash your hands with soap and water before and after you use this medicine.

  • Topical application routeApply a thin layer of the medicine to the affected area. Rub it in gently.

  • Do not shower, bathe, or wash the affected area for at least 30 minutes after you apply Pennsaid® or Solaraze® or 1 hour after you apply Voltaren®.

  • Wait until the medicine dries before you cover the treated skin with gloves or clothing. Do not let the treated skin touch any other person's skin until the medicine is completely dry.

  • Do not use external heat or bandages on the treated skin or joint.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

What to do if you miss a dose of Xrylix

Xrylix contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to diclofenac, aspirin or another NSAID medication.

Xrylix warnings

  • Tell your doctor if you are pregnant. It is not safe to use this medicine during the later part of pregnancy.

  • Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, asthma, bleeding problems, heart failure, high blood pressure, other heart or blood vessel problems, a recent heart attack, or a history of stomach ulcers or bleeding. Tell your doctor if you drink alcohol.

  • This medicine may cause the following problems:Higher risk of blood clot, heart attack, heart failure, or strokeBleeding in your stomach or intestinesLiver problemsKidney problems and high potassium levelsSerious skin reactions

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg, sudden or severe headache, or problems with vision, speech, or walking

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Unusual bleeding, bruising, or weakness

Xrylix interactions

  • Do not use any other NSAID unless your doctor says it is okay. Some other NSAIDs are aspirin, diflunisal, ibuprofen, naproxen, or salsalate.

  • Some foods and medicines can affect how diclofenac works. Tell your doctor if you are using any of the following:Acetaminophen, cyclosporine, digoxin, lithium, methotrexate, pemetrexedBlood pressure medicineBlood thinner (including warfarin)Diuretic (water pill)Medicine to treat depressionSteroids (including dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone)

  • Topical application routeDo not put cosmetics or skin care products on the treated skin. You may use sunscreen, insect repellant, lotion, or other topical medicines after using Pennsaid®. However, wait until the medicine is completely dry before you apply anything else.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Xrylix side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, or red skin rash

  • Bloody or black, tarry stools, severe stomach pain, vomiting blood or material that looks like coffee grounds

  • Change in how much or how often you urinate

  • Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, unusual sweating, faintness

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg, sudden or severe headache, or problems with vision, speech, or walking

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Unusual bleeding, bruising, or weakness

Less Serious Side Effects

  • Dry, flaky, or scaly skin

  • Mild headache

  • Mild skin rash, itching, or redness

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