Zileuton ER Coupons & Prices

Zileuton ER is a generic extended release prescription drug that prevents asthma attacks by inhibiting the chemicals that cause swelling and airway constriction in the lungs when exposed to allergens. Zileuton ER is the active ingredient in Zyflo CR. The pharmacy price of Zileuton ER is $3,493.38, but with SingleCare's Zileuton ER coupon, it costs $324.00.

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Zileuton ER coupon at CVS Pharmacy
$327.00
$ 324.00
$3 off with signupwith signup

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Zileuton ER coupon at Walgreens Pharmacy
$342.78
$ 339.78
$3 off with signupwith signup

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Zileuton ER coupon at Food Lion Pharmacy
$ 1,022
Zileuton ER coupon at Kroger Pharmacy
$1566.18
$ 1,563
$3 off with signupwith signup
Zileuton ER coupon at Harris Teeter Pharmacy
$1566.18
$ 1,563
$3 off with signupwith signup
Zileuton ER coupon at Costco Pharmacy
$ 1,677
$1909.06
$ 1,906
$3 off with signupwith signup
$3100.15
$ 3,097
$3 off with signupwith signup
$3100.15
$ 3,097
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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About Zileuton ER

Zileuton ER is a generic extended release prescription drug that prevents asthma attacks by inhibiting the chemicals that cause swelling and airway constriction in the lungs when exposed to allergens. Zileuton ER is the active ingredient in Zyflo CR. The pharmacy price of Zileuton ER is $3,493.38, but with SingleCare's Zileuton ER coupon, it costs $324.00.

Zileuton ER Price History & Information

Price History for Zileuton Er

120 count, tablet extended release 12 hour, 600mg

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Zileuton Er

120 count, tablet extended release 12 hour, 600mg

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Zileuton ER

Zileuton ER is a generic extended release prescription drug that prevents asthma attacks by inhibiting the chemicals that cause swelling and airway constriction in the lungs when exposed to allergens. Zileuton ER is the active ingredient in Zyflo CR. The pharmacy price of Zileuton ER is $3,493.38, but with SingleCare's Zileuton ER coupon, it costs $324.00.

Zileuton ER FAQs

How much does Zileuton ER cost without insurance?

Zileuton ER is an expensive medication even as a generic. On average, uninsured customers can expect to pay $3,493.38. However, $324.00 is all you pay with a SingleCare Zileuton ER coupon.

How much does Zileuton ER cost with insurance?

The amount of your Zileuton ER copay depends on your insurance plan. Your copay could be extremely high. With SingleCare, Zileuton ER costs $324.00, which may be lower than your insurance copay and may be your best option if your insurance does not cover Zileuton ER. Compare your Zileuton ER copay cost with your price using a SingleCare discount card. The difference may be considerable.

Does Medicare cover Zileuton ER and how much does it cost?

Zileuton ER is rarely covered by Medicare Part D and Medicare Advantage prescription drug plans. Medicare patients should consider using a SingleCare Zileuton ER coupon which lowers the cost of Zileuton ER to only $324.00.

What is the brand name of Zileuton ER?

Zileuton ER is a generic prescription drug manufactured by Rising, Prasco, Par, and Aristos as an alternative to Zyflo CR, a brand-name drug manufactured by Chiesi. Generic Zileuton ER does not cost much less than Zyflo CR, but the copay cost may be slightly lower.

What is Zileuton ER?

Zileuton ER is a generic prescription drug that prevents asthma attacks by blocking the chemicals that cause asthma. These chemicals are produced by the lungs and white blood cells in response to a foreign substance, such as pollen. They activate muscle contractions that narrow the airways and provoke a “swelling response” that both narrows airways and fills lung spaces with mucus. The result is an asthma attack, a significant reduction in the ability to breathe.

Zileuton ER only helps to prevent asthma attacks over the long term and cannot treat an active (acute) asthma attack.

Zileuton ER is taken as a tablet twice daily one hour after a meal. Dosage may vary depending on the severity of the underlying condition. Zileuton ER also is provided in an immediate release format.

What are the side effects of Zileuton ER?

Most people will not experience side effects when taking Zileuton ER, and those side effects will often be minimal. The most common side effects of Zileuton ER, experienced by about 1 in 20 patients, are cold symptoms, nausea, and sore throat. Less common side effects (experienced by less than one in a hundred patients) include upset stomach, nausea, chest pain, muscle pain, headache, diarrhea, weakness, and trouble sleeping. Mental and mood changes are very rare and include insomnia, behavior changes, anxiety, depression, or suicidal thoughts.

Allergic reactions are very rare (less than one percent of patients), but include rashes and skin redness. Discontinue Zileuton ER at any sign of an allergic reaction.

This is not a complete list of side effects. As always, consult with your physician about any concerns or questions you have regarding Zileuton ER and its side effects.

Where are Zileuton ER coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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