What is Zohydro Er: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 31, 2020

Zohydro Er overview

BRAND NAMES:

  • Hysingla ER, Zohydro ER

Generic Names:

  • Hydrocodone Bitartrate Er

Uses:

  • Treats severe pain. This medicine is a narcotic pain reliever.

Therapeutic Classes:

  • Analgesic

Forms:

  • Long Acting Capsule, Long Acting Tablet

How it’s taken:

  • By mouth

What is Zohydro Er used for?

Zohydro ER is an opioid pain medication. This medication contains hydrocodone, that is used to relieve severe ongoing pain. Zohydro ER works in the brain to change the way the body feels and reacts to pain.

What form(s) does Zohydro Er come in

  • Long Acting Capsule

  • Long Acting Tablet

What are common Zohydro Er doses?

  • Capsule Extended Release 12 Hour 10MG

  • Capsule Extended Release 12 Hour 15MG

  • Capsule Extended Release 12 Hour 20MG

  • Capsule Extended Release 12 Hour 30MG

  • Capsule Extended Release 12 Hour 40MG

  • Capsule Extended Release 12 Hour 50MG

Common Zohydro Er prescriptions

  • Zohydro ER
    10mg capsule er 12 hour abuse-deterrent

  • Zohydro ER
    15mg capsule er 12 hour abuse-deterrent

  • Zohydro ER
    20mg capsule er 12 hour abuse-deterrent

  • Zohydro ER
    30mg capsule er 12 hour abuse-deterrent

  • Zohydro ER
    40mg capsule er 12 hour abuse-deterrent

  • Zohydro ER
    50mg capsule er 12 hour abuse-deterrent

  • Zohydro ER
    10mg capsule extended release 12 hour

  • Zohydro ER
    15mg capsule extended release 12 hour

  • Zohydro ER
    30mg capsule extended release 12 hour

How to take Zohydro Er

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Take this medicine at the same time each day.

  • An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

  • Swallow the capsule or tablet whole with water. Take one tablet at a time, with enough water so you can easily swallow it as soon as you place it in your mouth. Do not presoak, lick, or wet the tablet before you place it in your mouth. Do not crush, break, chew, or dissolve it.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: If you miss a dose, skip the missed dose and take your next dose as usual. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • Swallow the capsule or tablet whole with water. Take one tablet at a time, with enough water so you can easily swallow it as soon as you place it in your mouth. Do not presoak, lick, or wet the tablet before you place it in your mouth. Do not crush, break, chew, or dissolve it.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Take this medicine at the same time each day.

  • An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

  • Missed dose: If you miss a dose, skip the missed dose and take your next dose as usual. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

What to do if you miss a dose of Zohydro Er

Zohydro Er contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to hydrocodone, or if you have severe breathing problems, or stomach or bowel blockage (including paralytic ileus).

Zohydro Er warnings

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, breathing or lung problems (including apnea), heart failure, heart rhythm problems (such as congenital long QT syndrome, slow heartbeat), adrenal problems, digestion problems, pancreas problems, or a history of depression, head injury, seizures, or drug or alcohol abuse.

  • This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Increased risk of heart rhythm problem (such as QT prolongation)Serotonin syndrome (when used with certain medicines)

  • This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

Zohydro Er interactions

  • Some medicines can affect how hydrocodone works. Tell your doctor if you are using any of the following:Carbamazepine, erythromycin, ketoconazole, lactulose, mirtazapine, phenytoin, rifampin, ritonavir, tramadol, trazodoneDiuretic (water pill)Medicine to treat depressionPhenothiazine medicine

  • Do not drink alcohol while you are using this medicine. Do not take any medicine that contains alcohol.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are also using buprenorphine, butorphanol, nalbuphine, pentazocine, or a muscle relaxer.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • Do not use this medicine if you have used an MAO inhibitor within the past 14 days.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone. An overdose in a child could cause death.

Zohydro Er side effects

Serious Side Effects

  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there

  • Severe constipation, stomach pain, or vomiting

  • Blue lips, fingernails, or skin

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Extreme dizziness, drowsiness, or weakness, slow heartbeat, seizures, and cold, clammy skin

  • Fast, pounding, or uneven heartbeat

  • Trouble breathing or slow breathing

  • Severe confusion, lightheadedness, dizziness, or fainting

Less Serious Side Effects

  • Mild drowsiness or sleepiness

  • Mild constipation, nausea

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