Omeprazole may be taken during pregnancy in some cases, but safety data is limited. Although proton pump inhibitors (PPIs) can cross the placenta, research has not linked omeprazole to birth defects, miscarriage, or preterm birth, and providers typically recommend trying lifestyle changes, antacids, or H2 blockers before using PPIs.
PPIs like omeprazole can cross the placenta, but a 2010 Danish study of 840,968 live births found no increased risk of major birth defects with first-trimester exposure.
There are no definitive studies confirming omeprazole’s safety in pregnancy, which is why providers often delay use until later trimesters.
Clinical guidance recommends a stepwise approach, starting with lifestyle changes, then antacids, H2 blockers, sucralfate, and PPIs if needed.
Comparison: Pregnancy-safe heartburn treatments |
||
|---|---|---|
| Treatment option | How it works | Pregnancy considerations |
| Antacids (calcium carbonate) | Neutralizes stomach acid | Fast-acting; calcium may cross the placenta |
| H2 blockers (famotidine) | Reduces acid production | Work faster than PPIs |
| Sucralfate | Coats stomach lining | No known fetal adverse effects |
| PPIs (omeprazole) | Strong acid suppression | Crosses the placenta; limited safety data |
Want a deeper look? Read our full analysis: Is it safe to take omeprazole during pregnancy?
Medical disclaimer: This content is for general informational purposes only and does not constitute medical advice. Always consult your OB-GYN or other healthcare provider before making changes to your medication regimen.
Evidence-based treatment recommendations for gastroesophageal reflux disease during pregnancy: A review, Medicine (Baltimore) (2022)
Kimberly Bowman, MD, was born in Fort Wayne, Indiana, and moved to Oklahoma, where she has spent most of her life. She earned her medical degree from the University of Oklahoma College of Medicine in 1996 and completed her residency in obstetrics and gynecology at the University of Florida at Gainesville in 2000. Upon returning to Oklahoma after residency, she has practiced in urban and rural Oklahoma and was also appointed as Assistant Professor at the University of Oklahoma School of Community Medicine in Tulsa. During her academic tenure, she served as the OB-GYN Clerkship Director and the Physician Assistant Program Director. She currently practices as a full-time OB-GYN hospitalist in Norman, Oklahoma. Dr. Bowman has been in practice since 2000 and is board-certified by the American Board of Obstetrics and Gynecology. In addition to full-time OB-GYN practice, she writes board-style review questions for the national OB-GYN resident CREOG exam and has lent her expertise to the creation of online educational content for the international publishing company Elsevier.
...Leandra Beabout is a freelance health and travel writer based between Indiana and India. Her work has been published in Reader's Digest, Greatist, The Guardian, Lonely Planet, and more. She was previously an English teacher and daily newspaper reporter.
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