Does tadalafil increase testosterone?

Medically reviewed by Chad Shaffer, MD
Physician
Written by Leandra Beabout
Contributor
Updated Jan 13, 2026  •  Published Jan 13, 2026
Fact Checked

No, tadalafil does not increase testosterone levels. Tadalafil is a PDE5 inhibitor that works by relaxing smooth muscle and increasing blood flow to help achieve and maintain an erection, but it does not affect sexual desire or hormone levels, which is why testosterone replacement is used separately when low testosterone causes ED.

Want to learn more about ED treatments?  Read our full analysis: Guide to erectile dysfunction pills, drugs, & medications

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Medical disclaimer: This content is for general informational purposes only and does not constitute medical advice. Always consult your urologist or healthcare provider before making changes to your medication regimen.

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Medically reviewed by Chad Shaffer, MD
Physician

Chad Shaffer, MD, earned his medical doctorate from Penn State University and completed a combined Internal Medicine and Pediatrics residency at the University of Pittsburgh Medical Center and Children’s Hospital of Pittsburgh. He is board certified by the American Board of Internal Medicine and the American Board of Pediatrics. He has provided full-service primary care to all ages for over 15 years, building a practice from start up to over 3,000 patients. His passion is educating patients on their health and treatment, so they can make well-informed decisions.

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Written by Leandra Beabout
Contributor

Leandra Beabout is a freelance health and travel writer based between Indiana and India. Her work has been published in Reader's Digest, Greatist, The Guardian, Lonely Planet, and more. She was previously an English teacher and daily newspaper reporter.

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