Does Wellbutrin help with anxiety?

Written by Karen BergerPharm.D.
Licensed Pharmacist
Updated Jan 13, 2026  •  Published Jan 13, 2026
Fact Checked

Wellbutrin can help with anxiety in some people, but it is not FDA-approved for anxiety. It may be used off-label, especially in people who have both depression and anxiety, since studies show it can be similarly effective to SSRIs, though some individuals may experience anxiety as a side effect.

Key takeaways

  • Wellbutrin is FDA-approved for depression, not anxiety, but it may be prescribed off-label for people who have both depression and anxiety when a healthcare provider determines it’s appropriate.

  • Research suggests Wellbutrin may reduce anxiety symptoms similarly to SSRIs in people with depression and anxiety, despite earlier concerns that it could worsen anxiety in some patients.

  • Wellbutrin is not safe for everyone, especially people with seizure disorders, eating disorders, or those stopping alcohol or certain medications abruptly.

Wellbutrin for anxiety

Category Wellbutrin (bupropion)
Primary classification Antidepressant (NDRI)
FDA-approved for anxiety No (anxiety use is off-label)
When it may be used for anxiety Often considered when someone has both depression and anxiety

Want to learn more? Read our full analysis: Wellbutrin for anxiety: What you should know

Prescription resources

Wellbutrin (bupropion) is a prescription antidepressant available in immediate-release, sustained-release, and extended-release forms. If you’re prescribed Wellbutrin for depression or off-label for anxiety, SingleCare can help you compare pharmacy prices and find discounts on generic bupropion.

Medical disclaimer: This content is for general informational purposes only and does not constitute medical advice. Always consult your healthcare provider before making changes to your medication regimen.

Written by Karen BergerPharm.D.
Licensed Pharmacist

After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.

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