How long does Zepbound fatigue last?

Medically reviewed by Jesse P. HoughtonMD, FACG
Fellow of the American College of Gastroenterology
Written by Heidi Borst
Contributor
Updated Oct 28, 2025  •  Published Oct 27, 2025
Fact Checked

The duration of Zepbound-related fatigue can vary significantly among individuals. For many users, fatigue tends to be temporary, lasting only a few days to a couple of weeks, as the body adjusts to the medication. However, some may experience prolonged fatigue, particularly if they are also adapting to lifestyle changes, such as a new diet or exercise routine.

Medically reviewed by Jesse P. HoughtonMD, FACG
Fellow of the American College of Gastroenterology

Jesse P. Houghton, MD, FACG, was born and raised in New Jersey, becoming the first physician in his entire family. He earned his medical degree from New Jersey Medical School (Now Rutgers Medical School) in 2002. He then went on to complete his residency in Internal Medicine and his fellowship in Gastroenterology at the Robert Wood Johnson University Hospital in 2005 and 2008, respectively. He moved to southern Ohio in 2012 and has been practicing at Southern Ohio Medical Center as the Senior Medical Director of Gastroenterology since that time.

Dr. Houghton is the author of What Your Doctor Doesn't (Have the Time to) Tell You: The Gastrointestinal System. He is also an Adjunct Clinical Associate Professor of Medicine at the Ohio University School of Osteopathic Medicine. He has been in practice since 2008 and has remained board-certified in both Internal Medicine and Gastroenterology for his entire career. He has lent his expertise to dozens of online articles in the medical field.

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Written by Heidi Borst
Contributor

Heidi Borst is a freelance parenting, relationship, health, and wellness writer based in Wilmington, NC, with a Journalism degree from Rutgers University. Her work has appeared on MSN, Yahoo, The Mighty, Scary Mommy, Parent Map, New Jersey Family and more. Heidi is a proud introvert, coffee enthusiast, fitness junkie, and boy mom.

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