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Key takeaways
Zepbound (tirzepatide) is a once-weekly injectable drug used for weight management and obstructive sleep apnea.
Without insurance, Zepbound costs about $1,523 per month.
If your insurance does not cover Zepbound, you can save money by using SingleCare coupons, purchasing a larger supply, or comparing pharmacy prices. You can also discuss alternative medications with your healthcare provider.
Zepbound is a once-weekly injectable prescription drug that contains the active ingredient tirzepatide. It is classified as a GIP/GLP-1 agonist and is currently only available in brand-name form, with no generic yet available. Zepbound is approved by the Food and Drug Administration (FDA) for weight loss and chronic weight management in adults with obesity and in people who are overweight with at least one weight-related health condition. Zepbound is also FDA approved for the treatment of moderate to severe obstructive sleep apnea (OSA) in adults with obesity. If your healthcare provider has recommended Zepbound, you’re likely curious about how much you’ll end up paying out of pocket per month.
How much does Zepbound cost per month?
The price you pay for Zepbound out of pocket varies by pharmacy and location. Dosage will also play a part, such as if you’re starting at the lowest dose. For example, without insurance or discounts, the out-of-pocket cost of Zepbound is an average of $1,523 for four, 5 mg pens, which is typically a one-month supply. The table below shows the average price of Zepbound, along with the lowest price you can pay with a free SingleCare coupon.
How dosage affects the price of Zepbound
Regardless of the reason you’re using Zepbound, healthcare providers typically will start you at the lowest dose of 2.5 mg once weekly for one month. Each dose is injected subcutaneously (under the skin) into the stomach, thigh, or upper arm. Your provider will instruct you on how to gradually increase your dose to a level that is effective, yet tolerable in terms of side effects. Everyone is different: Some people will respond more quickly than others. For weight management, patients typically inject 5 mg, 10 mg, or 15 mg once per week. For OSA, patients will typically use 10 mg or 15 mg injected once per week. However, this dose may vary, and patients often use in-between doses (such as 7.5 mg or 12.5 mg) for extended periods. Your healthcare provider will guide you on dosing.
Zepbound cost per month by dosage |
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|---|---|---|---|
| Dosage prescribed | Cost without insurance per month* | SingleCare cost per month | How to save |
| 2.5 mg dose injected once per week | $761 per 2, 5 mg pens | $475 | Get Zepbound coupons |
| 5 mg dose injected once per week | $1,523 per 4, 5 mg pens | $950 | Get Zepbound coupons |
| 7.5 mg dose injected once per week | $1,523 per 4, 7.5 mg pens | $950 | Get Zepbound coupons |
| 10 mg dose injected once per week | $1,523 per 4, 10 mg pens | $950 | Get Zepbound coupons |
| 12.5 mg dose injected once per week | $1,523 per 4, 12.5 mg pens | $950 | Get Zepbound coupons |
| 15 mg dose injected once per week | $1,523 per 4, 15 mg pens | $950 | Get Zepbound coupons |
Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of Dec. 9, 2025. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.
Is Zepbound covered by insurance?
Zepbound coverage varies widely by insurance provider. Some commercial insurance plans pay for weight loss drugs. Others do not pay for weight loss drugs at all, so if you are using Zepbound for weight loss, your plan may not cover the drug. Medicare prescription plans and Medicare Advantage plans do not cover weight loss drugs at this time, but this is a commonly discussed topic among government officials. Although the Trump Administration has announced lower costs, details still have to be approved. Zepbound is also FDA approved for OSA, so your plan may be more likely to cover the drug for this use.
The best way to find out if your specific insurance plan covers Zepbound is to check your plan’s formulary (list of covered drugs and their pricing tiers) or contact the member services department directly for more information. Injectable medications used for Type 2 diabetes or weight loss often require prior authorization. This means that your prescribing healthcare provider will have to submit information to your plan as to why the drug is medically necessary for you.
How to get Zepbound without insurance
It’s never easy to pay for medicine without insurance coverage, and brand-name injectable drugs like Zepbound are no exception. The good news is that there are ways you can save money on your Zepbound prescription. Manufacturer coupons, Zepbound savings cards, patient assistance programs, and other saving programs may be advertised on the Eli Lilly Zepbound website, but not everyone is eligible for these discounts. Here are some dependable ways to save money on your Zepbound prescription, even if you do not have insurance that covers your prescription:
- SingleCare discounts. Your free SingleCare prescription discount card gives you access to coupons you can use at local pharmacies to save nearly $600 per month. You can use SingleCare if you have insurance, too, like if your coinsurance or copay is too high, but you can’t use insurance and SingleCare coupons together.
- Ask about a three-month supply of Zepbound. Some pharmacies charge less when you purchase a larger quantity upfront. Purchasing a three-month supply may seem more expensive upfront, but it costs less per month.
- Check prices at different pharmacies. It’s best to get all your medication at the same pharmacy, so your pharmacist can screen for drug interactions and other issues. However, different pharmacies may offer different prices on Zepbound. It’s worth comparing prices at pharmacies near you. SingleCare.com makes this easy, and so does the SingleCare app.
- Talk to your healthcare provider about alternatives. If you have tried all the options, and Zepbound is still not affordable for you, you can check in with your healthcare provider about other alternatives that are effective but more affordable for you. They can give you medical advice based on your specific medical history.
- Zepbound, DailyMed (2025)
- How much should I expect to pay for Zepbound® (tirzepatide)?, Eli Lilly (2025)
- Anti-obesity drugs will not be covered by Medicare and Medicaid in 2026, American College of Gastroenterology (2025)
- Fact Sheet: President Donald J. Trump announces major developments in bringing most-favored-nation pricing to American patients, The White House (2025)