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Allergy Treatments and Medications

Medically reviewed by Karen BergerPharm.D.
Licensed Pharmacist
Updated Jul 6, 2026
Fact Checked

Key takeaways

  • Allergies affect almost one-third of adults in America, but there are effective treatments available. 

  • Common treatments for allergies include oral and nasal antihistamines, nasal steroids, and decongestants. 

  • Home remedies for allergies may include reducing exposure, improving air quality, and using saline rinses.

Allergies are one of the most common conditions in the world, affecting nearly one-third of U.S. adults. In simple terms, allergies are the body’s overreaction to a substance (an allergen). Some of the most common allergens are certain foods, animal hair (dander), pollen from plants like ragweed, and dust mites. Depending on the allergen, people with allergies usually experience symptoms such as sneezing, itchy or watery eyes, rashes or hives, or a runny nose. Fortunately, there are many treatment options available. Both over-the-counter (OTC) and prescription allergy medicine may help relieve symptoms and reduce allergen sensitivity.

How are allergies diagnosed?

For an evaluation and diagnosis, you can visit your primary care provider, who may refer you to an allergist or immunologist for testing.

Once your allergist or immunologist thoroughly understands your medical history and symptoms, they may order some tests. Many allergies can be diagnosed through simple skin or blood tests. However, these should be performed under the care of a specialist, as there is a risk that allergy symptoms may occur during the test.

These tests by themselves can't confirm whether you have allergies or not. Combining these test results and your medical history will help your healthcare provider form a diagnosis.

Allergy skin tests

Skin tests are generally more affordable than allergy blood tests. Plus, they give results quickly, usually within 15 to 20 minutes. Other medicines can sometimes affect skin tests, so tell your healthcare provider about any medication you’re taking, including prescription drugs, over-the-counter products, and supplements.

An allergy skin test is usually performed on the forearm, upper arm, or back. The healthcare provider will prick a small amount of the suspected allergen into the skin, and they may test several allergens simultaneously.

If you are allergic to one of the allergens, your skin will show signs of redness and swelling at the test spot.

Another skin test your healthcare provider may perform is to inject small amounts of a suspected allergen into the skin, rather than a drop on the surface, and monitor for any reaction. Allergic reactions will often appear within 20 minutes but can sometimes be delayed for a few hours. If this is the case, you must report the delayed reaction to your healthcare provider.

Skin testing is an effective, efficient, and usually pain-free way to find out if you have any allergies. In one appointment, you can meet with your allergist, test suspected allergens, get your results, and determine the best allergy treatment for you.

Allergy blood tests

There are several reasons why an allergist or immunologist may use blood tests rather than skin tests for your suspected allergies.

  • You’re taking medications that will interfere with a skin test

  • You have a preexisting skin condition, such as eczema or psoriasis

  • The allergen being tested could result in a large, severe positive reaction

Unlike skin tests, you will need to wait a few days for the lab results of your blood tests.

Both skin and blood tests are helpful and effective for testing allergies to some medicines, mold, food, pollen, insect stings, dust mites, and animal dander.

Allergy treatment options

After you’ve been diagnosed with an allergy, your healthcare provider will suggest the most appropriate treatment plan. Although allergies cannot be cured entirely, allergic reactions can be treated and prevented in several ways. Your sensitivity can also be significantly reduced, depending on your specific allergy.

These are the three common ways to treat and avoid allergic reactions. Your healthcare provider may recommend a combination of all three:

1. Avoid allergens

Although not always easy or practical, one of the most effective ways to manage allergies is to avoid exposure to the allergen. For example, if you have food allergies, you may become more careful about what you eat. If you have hay fever (also called allergic rhinitis), it may be best to shut the windows and stay indoors and away from grass when the pollen count is high. Allergy season could last nearly all year, depending on where you live.

2. Immunotherapy

Immunotherapy, also known as desensitization, is a treatment option that may be recommended in people with severe and persistent allergies. People who try immunotherapy have usually tried other treatment options without adequate relief. Under the supervision of a healthcare provider, patients are given small doses of the allergen in an injection form to help their bodies get used to it over time. If you experience severe allergy symptoms, talk to your healthcare provider about using allergy shots. 

3. Medication

You can purchase the appropriate medication over the counter at your local pharmacy for many mild allergies. For more severe allergies, your healthcare provider may provide you with prescription medication. The most common types of allergy medications include:

  • Antihistamines

  • Decongestants

  • Steroids

Types of allergy medication

Several medications are available to help with allergies, both over-the-counter and prescription. They fall into a few groups, each working slightly differently to treat allergies. This allergy medications list includes antihistamines, decongestants, combination drugs, and steroids. 

Steroids

Steroids, also known as corticosteroids, can reduce inflammation caused by allergic rhinitis. They can help reduce sneezing, an itchy and runny nose, and nasal congestion.

Nasal steroids in particular, when used daily, are extremely effective in treating allergies. Nasal steroids, including Qnasl (beclomethasone) and Nasonex (mometasone), are prescription allergy medicines. There are also over-the-counter options, including Rhinocort Allergy (budesonide), Flonase Allergy Relief (fluticasone), and Nasacort Allergy 24hr (triamcinolone). Dymista (azelastine/fluticasone) is a prescription nasal spray that combines a nasal antihistamine and a nasal steroid. 

The most common side effects of nasal steroids for allergies include nasal dryness and nosebleeds. Serious side effects are more commonly associated with longer-term use of oral steroids like prednisone. 

Antihistamines

Oral antihistamines are commonly used to treat allergy symptoms. So how do they work? When people experience an allergic reaction, their immune system is triggered by an allergen (pollen, for example). This means that the immune system begins releasing chemicals called histamines. Histamines bind to specific receptors in the body, leading to uncomfortable allergy symptoms like itching and swelling.

As the name suggests, antihistamines block histamines' effects, preventing them from causing irritation and other symptoms of an allergic response.

The main side effect of antihistamines is drowsiness, which is more common in older antihistamines like diphenhydramine. However, there are some newer antihistamines available that are less sedating. It’s best to avoid alcohol when taking antihistamines, as it can worsen drowsiness.

Popular over-the-counter antihistamine brand names include Benadryl (diphenhydramine), Zyrtec (cetirizine), Allegra (fexofenadine), Claritin (loratadine), and Xyzal (levocetirizine). There are also OTC and prescription nasal antihistamines, such as azelastine nasal spray. 

RELATED: Allegra vs. Zyrtec: Main differences and similarities

Decongestants

Some of the most common allergy symptoms are nasal congestion and puffy eyes. This is because allergens can cause the tissues and blood vessels in your nose and sinuses to swell. A decongestant reduces the swelling of this tissue, which helps relieve the symptoms.

Decongestants are available as tablets, eye drops, nasal allergy sprays, and oral liquids. However, nasal spray decongestants should only be taken for a few days at a time, as prolonged use can actually cause symptoms to worsen.

Some of the most popular over-the-counter decongestants are:

  • Sudafed (pseudoephedrine)

  • Afrin (oxymetazoline)

  • Neo-Synephrine (phenylephrine)

Potential side effects of decongestants include increased blood pressure and insomnia. Decongestants can also sometimes cause headaches, dizziness, and an increased or irregular heartbeat.

Combination drugs

These medicines combine both antihistamines and decongestants to treat multiple symptoms at once. 

Well-known over-the-counter combination allergy medicines include Claritin-D (loratadine and pseudoephedrine), Allegra-D (fexofenadine and pseudoephedrine), and Zyrtec-D (cetirizine and pseudoephedrine).

As with most medications and treatments, the best allergy medicine for one person may not be the right option for someone else. The right medication for you will be determined by your healthcare provider, taking into consideration your medical condition and medical history. Your healthcare provider will also consider any other medications you may be taking, as there is the possibility they could interact with some allergy medications. Your healthcare provider will also be able to monitor your progress and response to treatment and make any changes accordingly.

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This is not an exhaustive list of allergy medications. Always ask your healthcare provider for the best treatment for allergies based on your health condition and medical history.

Common side effects of allergy medicine

As with most medications, there is a risk of side effects. Although not a complete list of every possible side effect, here are a few of the most common for different allergy drug types:

  • Antihistamines: Common side effects include dry mouth, drowsiness, dizziness, blurred vision, constipation, and difficulty urinating. However, many newer, second-generation antihistamines are less likely to cause drowsiness and other side effects.

  • Decongestants: These can cause insomnia, nervousness, increased heart rate, and elevated blood pressure. Some people may also experience dizziness and headache.

  • Steroids: Nasal steroids for allergies typically cause a dry or irritated throat, an unpleasant taste in the mouth, and nosebleeds.

It’s best to speak with your healthcare provider for a full list of potential side effects. Your healthcare provider can guide you through any possible drug interactions and other precautions. 

Home remedies for allergies 

Many people also use a combination of natural remedies and medications to alleviate and treat allergies.

Popular ways to naturally prevent or reduce the impact of allergy symptoms are:

  • Vitamins and supplements, such as vitamin C, bromelain, butterbur, and quercetin, are thought to support the immune system and potentially reduce inflammation linked to allergies. However, the effectiveness of these remedies is not consistently supported by scientific evidence, and they may not work for everyone. Always consult a healthcare provider before starting any vitamins or supplements. 

  • Lifestyle changes could help you reduce exposure to allergens. Think: keeping windows closed during high pollen seasons, wearing a mask when outside during peak allergen times, and making dietary changes if certain foods seem to trigger allergy symptoms.

  • Improve the air quality at home by cleaning with a vacuum that has a HEPA air filter, maintaining your home’s HVAC system, and using a high-efficiency HEPA air cleaner in every room, which may help reduce the number of allergens in the air.

  • Saline rinses use salt water to help remove allergens from the nasal passages and sinuses. You can buy prepackaged kits or make your own.  

  • Inhaling steam can remove irritants from the nasal passage and clear out allergens. You can try holding your head above a bowl of steaming water, then covering your head with a towel to trap the steam. However, this should be done carefully to avoid burns.

Expert takeaway

"Allergy symptoms can range from mild and barely noticeable to more severe. It’s important to consult a healthcare provider to create an individualized treatment plan for your allergies," says Karen Berger, Pharm.D., member of the SingleCare Medical Review Board. 

Frequently asked questions about allergies

Can allergies be cured?

Generally, no. But you can treat and manage symptoms. Some treatments, like allergy shots, are so effective that they can significantly reduce your sensitivity to some allergens. Over time, with consistent treatment, you may experience decreased frequency and severity of allergies or allergic reactions.

How long do allergy symptoms last?

It varies, but allergy symptoms usually last as long as you are exposed to the allergen. Often, symptoms will disappear soon after exposure to the allergen is over. For example, if you're allergic to a friend's cat, your symptoms will likely subside a few hours after you leave their home. However, symptoms of seasonal allergies might persist for the duration of the pollen season.

Which allergy medicine works the fastest?

Antihistamine nasal sprays like azelastine tend to work quickly. Oral antihistamines like Zyrtec (cetirizine) also work quickly. You can discuss your options with your healthcare provider to determine which medicine will work the best and fastest for you. 

What is the best treatment for allergies?

The best treatment for allergies varies from person to person and depends on different factors, such as the type and severity of your allergies, your lifestyle, and personal preferences. Oral or nasal antihistamines and/or nasal steroids are commonly used and are considered very effective. Talk to your healthcare provider to find the best treatment option for your symptoms.

Is Claritin or Zyrtec better? Can I take both?

Both Claritin and Zyrtec are effective allergy medications. If you’re unsure which allergy medicine is best for you, ask a healthcare professional or your pharmacist to compare Zyrtec to Claritin. Most healthcare providers will typically recommend using just one oral antihistamine. If your symptoms are not controlled well with one medicine, check with your healthcare provider before adding on any other medicine. 

How can I calm my allergies down without medicine?

There are several natural ways to manage your allergies. Regular nasal rinses with a neti pot can clear allergens from your nasal passages, which may help reduce symptoms like a stuffy nose. Keeping your living environment clean, using HEPA filters, and avoiding known allergens can also help. Speak with your healthcare provider if you’re thinking about trying a natural treatment, such as a complementary or alternative remedy you haven’t tried before. 

Sources

Medically reviewed by Karen BergerPharm.D.
Licensed Pharmacist

After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.

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