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Concussion Treatments and Medications

Medically reviewed by Gerardo SisonPharm.D.
Licensed Pharmacist
Updated Aug 4, 2026
Datos Verificados

Key takeaways

  • The first-line treatment for a concussion is resting both physically and mentally for around 24 to 48 hours, and then gradually returning to normal daily activities. 

  • Over-the-counter medicine for concussion symptoms includes Tylenol (acetaminophen) for headaches and Dramamine Less Drowsy (meclizine) for dizziness and nausea.

  • Natural remedies for a concussion include getting enough sleep, doing light physical exercise, and eating a nutritious diet.

A concussion is a mild traumatic brain injury (TBI) that often occurs due to a strong blow to the head, which can cause the brain to rapidly move within the skull. The risk of getting one is higher in people who experience falls, contact sports, and car accidents. Symptoms may include a headache, dizziness, nausea, confusion, trouble sleeping, and even mood changes. Concussions can last anywhere from a few days to a month or more. Treatment involves resting, with some medications like acetaminophen being used to help manage symptoms. 

How is a concussion diagnosed?

A healthcare provider can diagnose a concussion based on a person’s symptoms and medical history. They’ll likely ask about the injury or event that caused the symptoms, how severe the symptoms are, and whether the person has a history of past concussions. An evaluation may include:

  • A neurological exam to test balance, coordination, vision, and reflexes

  • A cognitive test to check for any problems with memory or thinking

  • A screening for any mood or sleep changes

  • A physical exam or other tests for more severe problems, such as a skull fracture or brain bleeding

Blood tests and imaging exams are not recommended for all cases unless a more serious injury has occurred. For athletes, a professional may assess a concussion with the Sport Concussion Assessment Tool 6 (SCAT6). If symptoms worsen after a couple of days and include a worsening headache, vomiting, or seizures, it’s important to get emergency medical attention. 

RELATED: Urgent care vs. emergency room visits

Concussion treatment options

There is no single medication or procedure that can cure a concussion. In most cases, a concussion will heal on its own over time. However, some strategies may help improve recovery and manage symptoms. The first-line treatment for a concussion is mental and physical rest for 24 to 48 hours after the injury, followed by gradually returning to normal activities. Most people recover from a concussion within two to four weeks, depending on the severity. Certain medications may help with symptoms like headache, nausea, and dizziness. A healthcare provider will look at a person's overall health and symptoms before recommending a treatment plan.

Types of concussion medication

No medication can speed up the healing of a concussion since the brain heals on its own over time. However, some medications may be used to help manage symptoms while the brain recovers.

Pain relievers

For most people with a concussion, a common symptom is a headache that can feel like a migraine. Within the first few hours after the injury, Tylenol (acetaminophen) is the recommended pain reliever. It’s best to avoid NSAIDs like aspirin and ibuprofen, since taking these may increase the risk of bleeding, which could worsen a head injury. If there is no bleeding confirmed after the injury, an NSAID may be used later on, especially if headaches still occur.

Vestibular suppressants

Dizziness and nausea are other common symptoms of a concussion. Medicines for motion sickness, also called vestibular suppressants, can help reduce signals in the inner ear that cause these symptoms. Options include meclizine and dimenhydrinate, often found in Dramamine products, as well as the anticholinergic scopolamine patch. For more serious cases of nausea, Zofran (ondansetron) may be prescribed.

Antidepressants

For many people, a concussion also comes with sleep problems and mood changes, including depression. Tricyclic antidepressants, SRIs (selective serotonin reuptake inhibitors), or SNRIs (serotonin and norepinephrine reuptake inhibitors) may be prescribed to help with mood or sleep changes.

Stimulants

For serious cases of concussions that cause long-term effects on attention and concentration, stimulants may sometimes be prescribed. Studies suggest a stimulant like methylphenidate or dextroamphetamine can help improve mental fatigue and other cognitive symptoms

Triptans

For concussions that cause migraines, triptans like sumatriptan and rizatriptan can help manage symptoms like throbbing pain, sensitivity to light, and nausea. However, these medications are reserved for severe cases, especially when these headaches persist for weeks or months.

Over-the-counter concussion medicine

Many of the recommended medications for concussion symptoms can be found over the counter. For example, acetaminophen is widely accessible over the counter and can be used in the first few days of a concussion. Dimenhydrinate and meclizine are also found over the counter under the brand name Dramamine. In addition, melatonin is a commonly used supplement that may help with short-term sleep problems.

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What is the best medication for a concussion?

Drug nameSee SingleCare price
Tylenol
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Dramamine Less Drowsy
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Dramamine
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Zofran
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Amitriptyline
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Zoloft
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Melatonin
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Imitrex
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Ritalin
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This is not an exhaustive list of concussion medications. Always ask your healthcare provider for the best treatment for a concussion based on your health condition and medical history.

Common side effects of concussion medicine

Side effects depend on the class of medication being taken:

  • Acetaminophen causes very few side effects when taken at recommended doses, although it may cause liver problems at high doses. 

  • Antihistamines like dimenhydrinate and meclizine can cause drowsiness, dizziness, and a dry mouth.

  • Antidepressants can cause nausea, dizziness, and an upset stomach, although side effects are more common at the start of treatment.

  • Stimulants can cause restlessness, trouble sleeping, and an increased heart rate or blood pressure. 

This is not a complete list of side effects. Consult a healthcare provider about other potential side effects and risks while taking medication.

Home remedies for a concussion

Home care is the main part of treatment for a concussion. Since there are no medicinal cures for a concussion, some at-home remedies can help support the brain while it heals.

  • Rest: It’s important to rest not only physically but mentally during the first 24 to 48 hours. That often means taking time off from work or school.

  • Ease back into normal activity: After one or two days, you can gradually resume normal activities with light exercise and short mental tasks. 

  • Get enough sleep: Maintain good sleep hygiene by going to bed at the same time each night, keeping the room dark and quiet, and avoiding caffeine, heavy meals, and screens at bedtime.

  • Protect your head: Avoid any sports or activities that could potentially lead to another head injury. Experiencing a second concussion shortly after the first one could lead to serious complications. 

  • Eat a nutritious diet: A diet rich in lean protein, high-quality carbohydrates, and healthy fats can support the body and brain as it recovers. 

Contact a healthcare provider if symptoms worsen after one to two days of at-home care. It’s important to get emergency help for any severe symptoms like a severe headache, vomiting, confusion, weakness, seizures, or loss of consciousness.

Expert takeaway

Opt for acetaminophen instead of an NSAID like ibuprofen or naproxen in the first few days of a concussion. Choosing acetaminophen for a headache is a small choice that could help avoid the potential bleeding risks of NSAIDs after a head injury.

Frequently asked questions about concussion

How do you treat a concussion at home? 

A concussion can be treated at home with physical and mental rest for 24 to 48 hours. Acetaminophen can help manage a headache within the first few days of the injury, meclizine can help with dizziness or nausea, and melatonin may be helpful for sleep problems.

How long does it take to recover from a concussion? 

Many people recover within two to four weeks of the injury. However, older adults, children, and people who have had concussions in the past may take longer to recover. In some cases, symptoms may continue for months as persistent post-concussion syndrome

How do healthcare providers treat a concussion? 

The main treatment for a concussion is rest. No medication can cure a concussion, although some healthcare providers may recommend medications to help manage symptoms like a headache, nausea, or dizziness. 

What medication is used post-concussion? 

A typical concussion can be managed with rest and over-the-counter medications like acetaminophen and meclizine. If symptoms still occur post-concussion, a healthcare provider may prescribe medications like antidepressants, triptans, or stimulants, depending on the type and severity of symptoms. 

What medicine should you not take with a concussion? 

It’s important to avoid NSAIDs like aspirin, ibuprofen, and naproxen during the first few days of a concussion. These medications may increase the risk of bleeding in the brain. If you’re ever unsure about a medication, always ask a healthcare provider or pharmacist for advice. 

Sources

Medically reviewed by Gerardo SisonPharm.D.
Licensed Pharmacist

Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.

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