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Estradiol-Norethindrone Acet
Treats hot flashes, night sweats, and vaginal dryness due to menopause, and helps prevent osteoporosis after menopause.
Estrogen/Progestin Combination
Tablet
By mouth
Tablet
Disp Pack 28 Tablets
Activella
1 package (28 tablets), 1-0.5mg disp pack
Activella
28 tablets disp pack
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
This medicine comes in a dispenser pack with a calendar reminder dial.To use this dispenser, first turn the inner disc so the current day of the week is lined up with the plastic tab. Pull the plastic tab up and break if off. Remove the first tablet.To get the next tablet out (on the next day), turn the dial one space clockwise as shown by the arrow.The dial can be turned only after the tablet in the opening has been removed. This will help you remember to take 1 tablet every day.
Your doctor will tell you how much medicine to use. Do not use more than directed.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Your doctor will tell you how much medicine to use. Do not use more than directed.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
This medicine comes in a dispenser pack with a calendar reminder dial.To use this dispenser, first turn the inner disc so the current day of the week is lined up with the plastic tab. Pull the plastic tab up and break if off. Remove the first tablet.To get the next tablet out (on the next day), turn the dial one space clockwise as shown by the arrow.The dial can be turned only after the tablet in the opening has been removed. This will help you remember to take 1 tablet every day.
This medicine is not right for everyone. Do not use it if you had an allergic reaction to estradiol or norethindrone, you are pregnant, or you have liver disease. Do not use it if you have had breast cancer, uterine cancer, unusual vaginal bleeding, or problems with blood clots (such as deep vein thrombosis or stroke).
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Vision changes, vision loss, double vision, migraine headache
You may need to stop using this medicine for a few weeks before and after surgery, or if you need to stay in bed for a long time. This is because of the risk of blood clots.
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. You should have regular pelvic exams, breast exams, and mammograms as directed by your doctor.
This medicine may cause the following problems:Higher risk of heart attack, stroke, or blood clotsHigher risk of endometrial cancer, breast cancer, or uterine cancerHigher risk of dementiaGallbladder diseaseHigh calcium levels
Tell your doctor if you have kidney disease, heart disease, asthma, diabetes, endometriosis, epilepsy, migraine headaches, porphyria, lupus, an underactive thyroid, high blood pressure, or high cholesterol. Tell your doctor if you have ever had liver problems caused by pregnancy or estrogen, if you smoke, or if you had a hysterectomy.
Tell your doctor if you have had a heart attack, bleeding problems, or any kind of cancer.
Pregnancy after menopause is not likely, but if you think you could be pregnant, tell your doctor. This medicine could harm an unborn baby.
Tell your doctor if you have kidney disease, heart disease, asthma, diabetes, endometriosis, epilepsy, migraine headaches, porphyria, lupus, an underactive thyroid, high blood pressure, or high cholesterol. Tell your doctor if you have ever had liver problems caused by pregnancy or estrogen, if you smoke, or if you had a hysterectomy.
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Some medicines can affect how estradiol/norethindrone works. Tell your doctor if you are using St John's wort, carbamazepine, clarithromycin, erythromycin, itraconazole, ketoconazole, phenobarbital, rifampin, or ritonavir.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. You should have regular pelvic exams, breast exams, and mammograms as directed by your doctor.
You may need to stop using this medicine for a few weeks before and after surgery, or if you need to stay in bed for a long time. This is because of the risk of blood clots.
This medicine may cause the following problems:Higher risk of heart attack, stroke, or blood clotsHigher risk of endometrial cancer, breast cancer, or uterine cancerHigher risk of dementiaGallbladder diseaseHigh calcium levels
Serious Side Effects
Unusual or unexpected vaginal bleeding or heavy bleeding
Vision changes, vision loss, double vision, migraine headache
Sudden or severe stomach pain, nausea, or vomiting
Numbness or weakness on one side of your body
Sudden or severe headache, problems with vision, speech, or walking
Chest pain that may spread, trouble breathing, coughing up blood, unusual sweating, fainting
Breast lumps
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Less Serious Side Effects
Back pain
Nausea, stomach pain, or upset stomach
Swelling in your hands, ankles, or feet
Light, irregular vaginal bleeding or spotting
Swollen or tender breasts
Mild headache or trouble sleeping
Health education, drug info, wellness & more
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2025 SingleCare Administrators. All rights reserved
© 2025 SingleCare Administrators. All rights reserved