Activella is a combination drug used to treat symptoms of menopause such as hot flashes and vaginal changes, and to prevent bone loss in older women. The generic version of Activella is estradiol-norethindrone and is currently available commercially. The average retail price of Activella is about $360.61 per 1, 1 package (28 tablets), 1-0.5mg disp pack. You can reduce this cost to $28.20 per 1, 1 package (28 tablets), 1-0.5mg disp pack of generic Activella by using a SingleCare Activella coupon at participating pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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Activella is a combination drug used to treat symptoms of menopause such as hot flashes and vaginal changes, and to prevent bone loss in older women. The generic version of Activella is estradiol-norethindrone and is currently available commercially. The average retail price of Activella is about $360.61 per 1, 1 package (28 tablets), 1-0.5mg disp pack. You can reduce this cost to $28.20 per 1, 1 package (28 tablets), 1-0.5mg disp pack of generic Activella by using a SingleCare Activella coupon at participating pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Activella Retail Price | Estradiol-Norethindrone Acet Retail Price | Estradiol-Norethindrone Acet SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | - | $124.88 | $29.12 |
| Walmart | - | $77.56 | $29.12 |
| Walgreens | - | $56.56 | $52.36 |
| Kroger Pharmacy | $337.12 | $140.34 | $29.96 |
| Albertsons Pharmacy | - | $137.76 | $41.72 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Activella is a combination drug used to treat symptoms of menopause such as hot flashes and vaginal changes, and to prevent bone loss in older women. The generic version of Activella is estradiol-norethindrone and is currently available commercially. The average retail price of Activella is about $360.61 per 1, 1 package (28 tablets), 1-0.5mg disp pack. You can reduce this cost to $28.20 per 1, 1 package (28 tablets), 1-0.5mg disp pack of generic Activella by using a SingleCare Activella coupon at participating pharmacies.
The price of 1, 1 package (28 tablets), 1-0.5mg disp pack of Activella without insurance is about $360.61. With a SingleCare Activella coupon you can bring down your cost for 1, 1 package (28 tablets), 1-0.5mg disp pack of generic Activella to $28.20. Take our free coupons to local pharmacies such as Target, Longs Drugs, or Walmart to redeem these discounts.
You’ll have to check with your pharmacist or healthcare provider to calculate your copay with insurance coverage, as costs vary by healthcare plan. With a SingleCare Activella discount card, you could pay a discounted price of $28.20 on an generic Activella prescription containing 1, 1 package (28 tablets), 1-0.5mg disp pack. This could be cheaper than your insurance. To compare Activella prices, ask the pharmacist to run your card before you buy.
Medicare does not typically offer coverage for Activella. Without coverage from Medicare, patients will have to pay around $360.61 per refill of 1, 1 package (28 tablets), 1-0.5mg disp pack. Fortunately, you can use SingleCare’s savings card to save on this prescription drug. Pay a discounted price of $28.20 per 1, 1 package (28 tablets), 1-0.5mg disp pack for generic Activella when you use our card. Just present your card at any popular pharmacy to maximize your Activella savings.
Activella is a brand-name drug manufactured by Novo Nordisk, estradiol-norethindrone is the generic version.
Activella is a drug that combines estradiol and norethindrone to treat symptoms of menopause in women. Symptoms can include hot flashes, vaginal dryness, and changes in the vagina. These symptoms are caused by the body making less estrogen. This drug may also be used to prevent osteoporosis (bone loss) in menopausal women.
Estradiol, a form of estrogen, is a female sex hormone that helps with menopausal hot flashes and night sweats. It also eases vaginal symptoms of menopause, such as dryness, itching, burning, and discomfort with intercourse. While norethindrone, a form of progestin, helps to reduce the risk of cancer of the uterus which can be caused by using estrogen.
Activella is not recommended for you if you have liver disease, a bleeding disorder, unusual vaginal bleeding, history of hormone-dependent cancer (such as breast, uterine, ovarian, or thyroid cancer), have had your uterus removed, or if you have ever had a heart attack, stroke, a blood clot, or if you will be having major surgery.
Common Activella side effects typically include body aches or pain, chills or fever, cold or flu-like symptoms, difficulty breathing, headache, itching of the vagina or genital area, non-menstrual vaginal bleeding, pain during sexual intercourse, thick, white vaginal discharge with no odor or with a mild odor, unusual tiredness or weakness.
This is not a complete list of side effects so you can also experience other side effects while using this medication. Consult your healthcare provider for medical advice on the risks and benefits involved with using Activella. You are also encouraged to report negative side effects of Activella to the FDA.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved