Activella Coupons & Prices

Activella is a combination drug used to treat symptoms of menopause such as hot flashes and vaginal changes, and to prevent bone loss in older women. The generic version of Activella is estradiol-norethindrone and is currently available commercially. The average retail price of Activella is about $360.61 per 1, 1 package (28 tablets), 1-0.5mg disp pack. You can reduce this cost to $28.20 per 1, 1 package (28 tablets), 1-0.5mg disp pack of generic Activella by using a SingleCare Activella coupon at participating pharmacies.

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Activella coupon at CVS Pharmacy
$31.20
$ 28.20
$3 off with signupwith signup

Show this free card to your pharmacist.

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Activella coupon at Kroger Pharmacy
$32.23
$ 29.23
$3 off with signupwith signup

Save an extra $3 on any eligible prescription! Sign up for free

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Activella coupon at Harris Teeter Pharmacy
$32.23
$ 29.23
$3 off with signupwith signup
Activella coupon at Costco Pharmacy
$ 30.00
Activella coupon at Walmart Neighborhood Market Pharmacy
$36.64
$ 33.64
$3 off with signupwith signup
Activella coupon at Walmart Pharmacy
$36.64
$ 33.64
$3 off with signupwith signup
$37.69
$ 34.69
$3 off with signupwith signup
$39.99
$ 36.99
$3 off with signupwith signup
$ 42.59

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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About Activella

Activella is a combination drug used to treat symptoms of menopause such as hot flashes and vaginal changes, and to prevent bone loss in older women. The generic version of Activella is estradiol-norethindrone and is currently available commercially. The average retail price of Activella is about $360.61 per 1, 1 package (28 tablets), 1-0.5mg disp pack. You can reduce this cost to $28.20 per 1, 1 package (28 tablets), 1-0.5mg disp pack of generic Activella by using a SingleCare Activella coupon at participating pharmacies.

Activella Price History & Information

Price History for Activella (Brand) & Estradiol-Norethindrone Acet (Generic)

1 count, disp pack, 28 tablets

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Activella (Brand) & Estradiol-Norethindrone Acet (Generic)

1 count, disp pack, 28 tablets
PharmacyActivella Retail PriceEstradiol-Norethindrone Acet Retail PriceEstradiol-Norethindrone Acet SingleCare Price
CVS Pharmacy-$124.88$29.12
Walmart-$77.56$29.12
Walgreens-$56.56$52.36
Kroger Pharmacy$337.12$140.34$29.96
Albertsons Pharmacy-$137.76$41.72

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Activella

Activella is a combination drug used to treat symptoms of menopause such as hot flashes and vaginal changes, and to prevent bone loss in older women. The generic version of Activella is estradiol-norethindrone and is currently available commercially. The average retail price of Activella is about $360.61 per 1, 1 package (28 tablets), 1-0.5mg disp pack. You can reduce this cost to $28.20 per 1, 1 package (28 tablets), 1-0.5mg disp pack of generic Activella by using a SingleCare Activella coupon at participating pharmacies.

Activella FAQs

How much does Activella cost without insurance?

The price of 1, 1 package (28 tablets), 1-0.5mg disp pack of Activella without insurance is about $360.61. With a SingleCare Activella coupon you can bring down your cost for 1, 1 package (28 tablets), 1-0.5mg disp pack of generic Activella to $28.20. Take our free coupons to local pharmacies such as Target, Longs Drugs, or Walmart to redeem these discounts.

How much does Activella cost with insurance?

You’ll have to check with your pharmacist or healthcare provider to calculate your copay with insurance coverage, as costs vary by healthcare plan. With a SingleCare Activella discount card, you could pay a discounted price of $28.20 on an generic Activella prescription containing 1, 1 package (28 tablets), 1-0.5mg disp pack. This could be cheaper than your insurance. To compare Activella prices, ask the pharmacist to run your card before you buy.

Does Medicare cover Activella and how much does it cost?

Medicare does not typically offer coverage for Activella. Without coverage from Medicare, patients will have to pay around $360.61 per refill of 1, 1 package (28 tablets), 1-0.5mg disp pack. Fortunately, you can use SingleCare’s savings card to save on this prescription drug. Pay a discounted price of $28.20 per 1, 1 package (28 tablets), 1-0.5mg disp pack for generic Activella when you use our card. Just present your card at any popular pharmacy to maximize your Activella savings.

Is there a generic of Activella?

Activella is a brand-name drug manufactured by Novo Nordisk, estradiol-norethindrone is the generic version.

What is Activella?

Activella is a drug that combines estradiol and norethindrone to treat symptoms of menopause in women. Symptoms can include hot flashes, vaginal dryness, and changes in the vagina. These symptoms are caused by the body making less estrogen. This drug may also be used to prevent osteoporosis (bone loss) in menopausal women.

Estradiol, a form of estrogen, is a female sex hormone that helps with menopausal hot flashes and night sweats. It also eases vaginal symptoms of menopause, such as dryness, itching, burning, and discomfort with intercourse. While norethindrone, a form of progestin, helps to reduce the risk of cancer of the uterus which can be caused by using estrogen.

Activella is not recommended for you if you have liver disease, a bleeding disorder, unusual vaginal bleeding, history of hormone-dependent cancer (such as breast, uterine, ovarian, or thyroid cancer), have had your uterus removed, or if you have ever had a heart attack, stroke, a blood clot, or if you will be having major surgery.

What are the side effects of Activella?

Common Activella side effects typically include body aches or pain, chills or fever, cold or flu-like symptoms, difficulty breathing, headache, itching of the vagina or genital area, non-menstrual vaginal bleeding, pain during sexual intercourse, thick, white vaginal discharge with no odor or with a mild odor, unusual tiredness or weakness.

This is not a complete list of side effects so you can also experience other side effects while using this medication. Consult your healthcare provider for medical advice on the risks and benefits involved with using Activella. You are also encouraged to report negative side effects of Activella to the FDA.

Where are Activella coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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