Key takeaways
CombiPatch is a transdermal system skin patch used for female hormone replacement therapy for menopausal women.
The CombiPatch price averages $409 for 8 twice-weekly patches, enough medicine to last a month.
Many insurance plans cover CombiPatch, but if not, women can save money with a CombiPatch coupon, manufacturer’s coupons, price shopping, or switching to generic HRT medications.
CombiPatch is a brand-name prescription transdermal patch that contains estradiol, an estrogen, and norethindrone, a progestin. As a hormone replacement treatment, CombiPatch delivers estrogen and progestin to replace hormones that decline after menopause. This helps relieve many of the symptoms of menopause, including hot flashes, night sweats, vaginal dryness, and vaginal or vulvar atrophy. As a brand-name medication without any generic versions, CombiPatch can be an expensive option for people with or without insurance. Fortunately, there may be other discounts and savings options to lower the CombiPatch cost.
RELATED: Estrogen costs & coupons
What is the generic for CombiPatch?
There is currently no CombiPatch generic, even though all the CombiPatch patents have expired. A generic version will not be available until another pharmaceutical manufacturer decides to introduce one. That leaves only the brand-name version, though generic estradiol-norethindrone acetate tablets are sold at pharmacies. It is uncertain when generic alternatives to CombiPatch will be available. However, there is at least one combination estrogen-progestin transdermal patch FDA-approved for menopause symptoms on the market: Climara Pro (estradiol and levonorgestrel).
Is CombiPatch covered by insurance?
CombiPatch is covered by some health insurance plans, but people with Medicare Part D or Medicaid are less likely to be covered. Insurance plans that cover CombiPatch tend to classify the drug in higher copay tiers, so expect the copay to be higher than for more commonly prescribed generic drugs. But copay is only one aspect of out-of-pocket costs. Coinsurance amounts and any coverage gaps should also be considered. Contact your health insurance plan or pharmacist to see whether your prescription will be covered and what the potential out-of-pocket costs may be.
RELATED: Does Medicare cover hormone replacement therapy?
How much does CombiPatch cost without insurance?
Without insurance, eight twice-weekly patches of CombiPatch can cost an average retail price of $409. CombiPatch comes in two dosage strengths, but regardless of the dose, women without coverage for CombiPatch can expect to pay about $51 per skin patch and $102 per week. A year’s worth of CombiPatch treatment could cost over $5,000 without any cost-saving strategies.
One strategy to reduce the cost is to ask the prescribing healthcare provider about generic options that can be taken separately. The goal of estrogen-progestin treatment for menopause is to get the benefits of estrogen replacement while adding a progestin to protect the uterine lining. An alternative therapy to CombiPatch may be a generic, oral estrogen-progestin product. Another option might be to use a generic estradiol patch with a separate progestin product. There will be trade-offs, so get medical advice about the pros and cons of generic estrogen-progestin treatments before switching.
Compare CombiPatch prices to related drugs |
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|---|---|---|---|
| Drug name | Price without insurance of brand-name drug | SingleCare price | Savings options |
| CombiPatch (estradiol/norethindrone) | $409 for 8 twice-weekly patches | $247 for 8 twice-weekly patches of brand-name CombiPatch at Kroger | See latest prices |
| Climara Pro (estradiol/levonorgestrel) | $352 for 4 weekly patches | $246 for 4 weekly patches of brand-name Climara Pro at Kroger | See latest prices |
| Activella (estradiol/norethindrone) | $360 for 28, 1-0.5 mg tablets | $29 for 28, 1-0.5 mg tablets of generic Activella at Kroger | See latest prices |
| Jinteli (estradiol/norethindrone) | $91 for 28, 1-5 mg-mcg tablets | $34 for 28, 1-5 mg-mcg tablets of generic Jinteli at Kroger | See latest prices |
| Prempro (conjugated estrogens/medroxyprogesterone) | $363 for 28, 0.3-1.5 mg tablets | $237 for 28, 0.3-1.5 mg tablets of brand-name Prempro at Kroger | See latest prices |
| Vagifem (estradiol) | $281 for 8 vaginal tablets | $40 for 8 vaginal tablets of generic Vagifem at CVS Pharmacy | See latest prices |
How to get CombiPatch without insurance
At around $409 per month, paying the full cash price for CombiPatch over several months may be challenging. Just six months of treatment will cost around $2,600. The manufacturer may offer a coupon or copay savings card that may help reduce the cost of your prescription. Other savings options, such as patient assistance programs, may be available, but the eligibility requirements may be hard to meet for some people. It is also possible to get CombiPatch or similar treatments at a reduced price through other options, such as a SingleCare prescription discount card.
1. Find CombiPatch discounts with a SingleCare savings card
The lowest SingleCare price for eight, twice-weekly CombiPatch transdermal patches is $247 at Kroger, about $160 less than the average price. Over the course of a year, those savings could be over $2,000. SingleCare is free to use and available to everyone. Registered members can save even more, and it’s fast and free to join.
Not all SingleCare participating pharmacies offer the same discount, so shop current CombiPatch discount prices at local pharmacies on SingleCare’s CombiPatch coupons page. Make sure to read the CombiPatch FAQs section on this page for important savings and drug information.
Save up to 80% on Combipatch with SingleCare
Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.
2. Use a manufacturer’s coupon
The manufacturer of CombiPatch may offer a coupon or copay savings card. Eligible patients could pay less for CombiPatch prescription fills. Restrictions may apply, so it’s important to check the offer’s terms and conditions.
3. Shop for the lowest CombiPatch price
Simply comparing prices at local pharmacies to find the lowest price for CombiPatch can save as much as $18 per box of eight twice-weekly patches. That’s the difference between the highest and lowest average retail prices for CombiPatch, and it could mean significant annual savings.
4. Ask the prescriber about a cheaper alternative to CombiPatch
Unfortunately, there is no generic version of CombiPatch. However, there may be cheaper alternatives. For example, generic estradiol-norethindrone acetate tablets may cost as little as $29 for 28, 1 mg/0.5 mg tablets at Kroger with a free coupon from SingleCare. Like CombiPatch, these generic tablets are FDA-approved to treat menopausal symptoms. It’s also possible to use generic Vivelle-Dot (estradiol transdermal patch), generic Estrogel (estradiol transdermal gel), or Estring (estradiol vaginal ring) along with a progestin product, depending on what symptoms you have. The convenience, effectiveness, and side effects may differ from those of CombiPatch, so it’s best to consult your healthcare provider for the best treatment option. However, the savings may be great enough that these options are worth exploring with a healthcare professional.
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The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of Aug. 5, 2026. Prices vary by pharmacy. Visit our coupon page for updated drug prices at pharmacies near you.
- CombiPatch estradiol/norethindrone acetate transdermal system patch prescribing information, DailyMed (NIH National Library of Medicine) (2024)
- Combipatch patent expiration, Pharsight
- Medically accurate: SingleCare’s Medical Review Board analyzes all of our content to confirm it’s in line with current medical advice.
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