What is Alphanate: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Feb 8, 2022

Alphanate overview

BRAND NAMES:

  • Alphanate, Humate-P, Wilate

Generic Names:

  • Alphanate

Uses:

  • Controls and prevents bleeding in hemophilia A and von Willebrand disease. Also used to prevent bleeding during surgery.

Therapeutic Classes:

  • Antihemophilic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Alphanate used for?

What form(s) does Alphanate come in

  • Injectable

What are common Alphanate doses?

  • Solution Reconstituted 250UNIT

Common Alphanate prescriptions

  • Alphanate
    1000unit solution reconstituted

  • Alphanate
    1500unit solution reconstituted

  • Alphanate
    2000unit solution reconstituted

  • Alphanate
    250unit solution reconstituted

  • Alphanate
    500unit solution reconstituted

How to take Alphanate

  • Swirl the Wilate® vial gently to dissolve the powder. Do not shake. Do not use the mixed liquid if it is cloudy, discolored, or has particles in it.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Injection routeCall your doctor or pharmacist for instructions.

  • You may store the Wilate® unopened vial in the refrigerator for up to 36 months. Do not freeze. You may also store it at room temperature for up to 6 months. Do not place it back in the refrigerator once stored at room temperature. Use the medicine right away after mixing it.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

What to do if you miss a dose of Alphanate

Alphanate contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to antihemophilic factor, von Willebrand factor, or to human plasma-derived products.

Alphanate warnings

  • Tell your doctor if you are pregnant or breastfeeding, you received a hepatitis A or hepatitis B vaccine shot, or you ever had a blood clot.

  • This medicine may increase your risk for blood clots, especially if you have a history of clots.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Call your doctor right away if you continue to have bleeding problems even after you use this medicine. Also call if your medicine does not seem to be working as well as usual.

  • This medicine is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. Although the risk is low, talk with your doctor if you have concerns.

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Unusual bleeding or bruising

  • Yellow skin or eyes

Alphanate interactions

  • This medicine may increase your risk for blood clots, especially if you have a history of clots.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Call your doctor right away if you continue to have bleeding problems even after you use this medicine. Also call if your medicine does not seem to be working as well as usual.

  • This medicine is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. Although the risk is low, talk with your doctor if you have concerns.

  • Tell your doctor if you are pregnant or breastfeeding, you received a hepatitis A or hepatitis B vaccine shot, or you ever had a blood clot.

Alphanate side effects

Serious Side Effects

  • Warmth or redness in your face, neck, arms, or upper chest

  • Yellow skin or eyes

  • Numbness or weakness on one side of your body, sudden or severe headache, problems with speech, vision, or walking

  • Unusual bleeding or bruising

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Chest pain, coughing up blood, or troubled breathing

  • Fever or chills, headache

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Lightheadedness, dizziness, fainting

  • Pain or weakness in your calf

Less Serious Side Effects

  • Pain, itching, burning, stinging, swelling, or a lump under your skin where the needle is placed

  • Nausea, vomiting, or loss of appetite

  • Joint or muscle pain

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