What is Phenylephrine HCl: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 11, 2022

Phenylephrine HCl overview

BRAND NAMES:

  • Altafrin, Prefrin Liquifilm

Generic Names:

  • Phenylephrine Hcl

Uses:

  • Treats uveitis and wide-angle glaucoma. Also used to dilate the pupil of the eye.

Therapeutic Classes:

  • Decongestant, Mydriatic-Cycloplegic

Forms:

  • Liquid

How it’s taken:

  • Into the eye

What is Phenylephrine HCl used for?

What form(s) does Phenylephrine HCl come in

  • Liquid

What are common Phenylephrine HCl doses?

  • Bottle 5ml of 10%

How to take Phenylephrine HCl

  • This medicine is an eye drop given by a nurse or other trained health professional.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store this medicine in the refrigerator.

  • You may need to use this medicine at home. Follow these steps: Ophthalmic routeWash your hands with soap and water before and after using this medicine. Ophthalmic routeLie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket. Insert the drops into the pocket, between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not allow the dropper to touch anything, including your eye. Put the cap on the bottle right away.

What to do if you miss a dose of Phenylephrine HCl

Phenylephrine HCl contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to phenylephrine, or if you have narrow-angle glaucoma, high blood pressure, or thyroid disease.

Phenylephrine HCl warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart disease, heart rhythm problems, diabetes, or blood vessel disease.

  • This medicine will make your eyes more sensitive to light. Wear sunglasses to protect your eyes.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Sudden, severe headache

Phenylephrine HCl interactions

  • Some medicines can affect how phenylephrine works. Tell your doctor if you are using atropine or any anesthetic medicine.

  • This medicine will make your eyes more sensitive to light. Wear sunglasses to protect your eyes.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Phenylephrine HCl side effects

Serious Side Effects

  • Sudden, severe headache

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, faintness

  • Fast, pounding, or uneven heartbeat

Less Serious Side Effects

  • Eye irritation, burning, or sensitivity to light

  • Blurred vision

  • Swelling, redness, or itching of the eyelids

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