What is Amoxapine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Amoxapine overview

BRAND NAMES:

Generic Names:

  • Amoxapine

Uses:

  • Treats depression. This medicine is a TCA.

Therapeutic Classes:

  • Antidepressant

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Amoxapine used for?

Amoxapine is an tricyclic antidepressant that changes the chemicals in the brain that are unbalanced to treat patients with anxiety, agitation, or depression.

What form(s) does Amoxapine come in

  • Tablet

What are common Amoxapine doses?

  • Tablet 25MG

  • Tablet 50MG

  • Tablet 100MG

  • Bottle 30 Tablets

Common Amoxapine prescriptions

  • Amoxapine
    30 tablets bottle

  • Amoxapine
    100mg tablet

  • Amoxapine
    25mg tablet

  • Amoxapine
    50mg tablet

How to take Amoxapine

  • You may take your medicine with food or milk to prevent nausea.

  • If you are taking amoxapine for depression, it may take up to 3 weeks before you start to feel better.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. If you take this medicine only at bedtime, do not take a missed dose in the morning without asking your doctor.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • You may take your medicine with food or milk to prevent nausea.

  • If you are taking amoxapine for depression, it may take up to 3 weeks before you start to feel better.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. If you take this medicine only at bedtime, do not take a missed dose in the morning without asking your doctor.

What to do if you miss a dose of Amoxapine

Amoxapine contraindications

  • This medicine is not right for everyone. Do not take it if you had an allergic reaction to amoxapine or to any other tricyclic antidepressant, or if you took an MAO inhibitor in the past 14 days.

Amoxapine warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart problems (including a recent heart attack), seizures, glaucoma, kidney disease, liver disease, asthma, overactive thyroid, or problems with urination.

  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.

  • Do not stop using this medicine suddenly without asking your doctor. You may need to decrease your dose slowly before you stop it completely.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Seizures

  • Uncontrollable muscle movements or twitching

Amoxapine interactions

  • Some medicines and foods can affect how amoxapine works. Tell your doctor if you are taking any of the following: Bepridil, halofantrine, pimozide, procarbazineAntibiotics, blood thinners (such as warfarin), or medicine for heart rhythm problems or high blood pressure

  • Do not stop using this medicine suddenly without asking your doctor. You may need to decrease your dose slowly before you stop it completely.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Amoxapine side effects

Serious Side Effects

  • Uncontrollable muscle movements or twitching

  • Lightheadedness or fainting, shallow breathing

  • Problems with balance or walking

  • Seizures

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Change in how much or how often you urinate

  • Fast or pounding heartbeat

  • Fever, sweating, confusion, irregular heartbeat, muscle stiffness

Less Serious Side Effects

  • Dry mouth

  • Blurred vision

  • Trouble sleeping, or drowsiness

  • Constipation

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