Lyllana is a brand-name prescription estrogen skin patch. It steadily delivers ethinyl estradiol through the skin to relieve the vasomotor symptoms of menopause, such as hot flashes, and prevent osteoporosis in women. Without insurance, women can expect to purchase Lyllana for an average retail price of $210.30 per 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box. A SingleCare Lyllana coupon could discount the generic Lyllana price to as low as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/20/2025
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Lyllana is a brand-name prescription estrogen skin patch. It steadily delivers ethinyl estradiol through the skin to relieve the vasomotor symptoms of menopause, such as hot flashes, and prevent osteoporosis in women. Without insurance, women can expect to purchase Lyllana for an average retail price of $210.30 per 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box. A SingleCare Lyllana coupon could discount the generic Lyllana price to as low as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Lyllana Retail Price | Estradiol Retail Price | Estradiol SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $142.00 | $106.72 | $72.80 |
| Walmart | $58.24 | $58.47 | $52.70 |
| Walgreens | $58.80 | $52.26 | $44.96 |
| Kroger Pharmacy | $172.00 | $113.45 | $73.04 |
| Albertsons Pharmacy | $195.68 | $136.12 | $58.56 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Lyllana is a brand-name prescription estrogen skin patch. It steadily delivers ethinyl estradiol through the skin to relieve the vasomotor symptoms of menopause, such as hot flashes, and prevent osteoporosis in women. Without insurance, women can expect to purchase Lyllana for an average retail price of $210.30 per 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box. A SingleCare Lyllana coupon could discount the generic Lyllana price to as low as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box.
Generic Lyllana costs $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box with a free Lyllana coupon from SingleCare. However, you could reduce this cost more depending on your Rx details. Use the dropdown menu above to enter your Rx info (i.e., brand/generic, form, dosage, quantity) to find the most accurate price of Lyllana with SingleCare near you.
The retail Lyllana price averages $210.30 per 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box. With a SingleCare discount card, purchase generic Lyllana for as little as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box.
Lyllana is sometimes covered by health insurance, sometimes not. When it is not covered, the insurance plan typically covers generic estradiol patches or other brands. For some insurance plans, the out-of-pocket cost for Lyllana could be high. If insurance coverage or cost is a problem, use a SingleCare Lyllana coupon without insurance to purchase generic Lyllana for as low as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box.
Most Medicare Part D drug plans cover Lyllana, but coverage varies between insurance providers. Lyllana is usually placed in higher-cost copay tiers, so the out-of-pocket cost may be high. If cost or coverage is an issue, a SingleCare Lyllana coupon may be the cheapest option.
Some Medicaid plans cover Lyllana, but many either don’t cover Lyllana or they consider it a nonpreferred drug. Nevertheless, all state Medicaid plans cover generic estradiol transdermal systems. If Medicaid Lyllana coverage is a problem, use a Lyllana coupon from SingleCare instead of Medicaid to purchase Lyllana at a discount price.
Women can purchase generic estradiol patches that work the same way and deliver the same daily dose as Lyllana (0.025 mg/day, 0.0375 mg/day, 0.05 mg/day, 0.075 mg/day, and 0.1 mg/day). Health insurance is more likely to cover generic Lyllana. With a SingleCare prescription discount card, the lowest price for estradiol patches is $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box.
Uninsured women have a number of ways to save on Lyllana and estrogen hormone replacement therapy, including:
Using SingleCare’s discount program along with SingleCare’s bonus loyalty program to save money
Switching to a generic estradiol transdermal system
Switching to a different type of estradiol medication, such as oral estradiol
Enrolling in Medicaid or Medicare Extra Help if the eligibility requirements can be met
Visiting a 340B provider or community health clinic that could sell Lyllana at a discount price
Applying to a patient assistance program that supplies discounted prescription drugs
Comparing pharmacy prices to find the best price
If switching medications looks like the best option, get medical advice from a healthcare professional about the options.
For estradiol patches, there are cheaper brand-name versions, such as Dotti. But the cheapest alternative is to purchase a generic estradiol transdermal system. With a SingleCare prescription discount card, generic Lyllana could cost as little as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box.
The cheapest medication options for hormone replacement therapy are generic estradiol tablets or generic estradiol topical gels. Other formats, such as injections, are more expensive. Effectiveness, side effects, and safety may vary based on the format, so get medical advice from a healthcare professional before switching.
You can use SingleCare coupons at most national pharmacies and grocery stores, such as Walgreens, Kroger, Walmart, CVS, Safeway, and more. Just text, email, print, or save your free Lyllana coupon to your mobile wallet and show a pharmacist at checkout.
SingleCare is accepted at most national pharmacies and grocers, including the following:
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved