Lyllana Coupons & Prices

Estradiol

Lyllana is a brand-name prescription estrogen skin patch. It steadily delivers ethinyl estradiol through the skin to relieve the vasomotor symptoms of menopause, such as hot flashes, and prevent osteoporosis in women. Without insurance, women can expect to purchase Lyllana for an average retail price of $210.30 per 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box. A SingleCare Lyllana coupon could discount the generic Lyllana price to as low as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box.

Set your location
Get alerted when the price
changes more than 10%

1 box1 box (8 twice weekly patches), 0.1mg/24 hrEdit

Unlock members-only prices.Free signup.

You have 0.00 in available bonus savings. Bonus savings will be automatically applied to your next eligible prescription fill.

Lyllana coupon at CVS Pharmacy
$46.88
$ 43.88
$3 off with signupwith signup

Show this free card to your pharmacist.

Coupon card loading
Lyllana coupon at Walmart Neighborhood Market Pharmacy
$60.44
$ 57.44
$3 off with signupwith signup

Save an extra $3 on any eligible prescription! Sign up for free

Members can save even more
and it's free to join

Lyllana coupon at Walmart Pharmacy
$60.44
$ 57.44
$3 off with signupwith signup
Lyllana coupon at Costco Pharmacy
$ 63.99
Lyllana coupon at Publix Pharmacy
$70.85
$ 67.85
$3 off with signupwith signup
Lyllana coupon at Kroger Pharmacy
$73.02
$ 70.02
$3 off with signupwith signup
$73.02
$ 70.02
$3 off with signupwith signup
$76.08
$ 73.08
$3 off with signupwith signup
$ 79.12

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/20/2025

Members save the most

Save big on your prescriptions
with the free SingleCare app.
4.8 average rating
About Lyllana

Lyllana is a brand-name prescription estrogen skin patch. It steadily delivers ethinyl estradiol through the skin to relieve the vasomotor symptoms of menopause, such as hot flashes, and prevent osteoporosis in women. Without insurance, women can expect to purchase Lyllana for an average retail price of $210.30 per 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box. A SingleCare Lyllana coupon could discount the generic Lyllana price to as low as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box.

Lyllana Price History & Information

Price History for Lyllana (Trademark Generic) & Estradiol (Generic)

1 count, box, 1 box (8 twice weekly patches), 0.05mg/24 hr

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Lyllana (Trademark Generic) & Estradiol (Generic)

1 count, box, 1 box (8 twice weekly patches), 0.05mg/24 hr
PharmacyLyllana Retail PriceEstradiol Retail PriceEstradiol SingleCare Price
CVS Pharmacy$142.00$106.72$72.80
Walmart$58.24$58.47$52.70
Walgreens$58.80$52.26$44.96
Kroger Pharmacy$172.00$113.45$73.04
Albertsons Pharmacy$195.68$136.12$58.56

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Lyllana

Lyllana is a brand-name prescription estrogen skin patch. It steadily delivers ethinyl estradiol through the skin to relieve the vasomotor symptoms of menopause, such as hot flashes, and prevent osteoporosis in women. Without insurance, women can expect to purchase Lyllana for an average retail price of $210.30 per 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box. A SingleCare Lyllana coupon could discount the generic Lyllana price to as low as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box.

Lyllana FAQs

How much is Lyllana with SingleCare?

Generic Lyllana costs $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box with a free Lyllana coupon from SingleCare. However, you could reduce this cost more depending on your Rx details. Use the dropdown menu above to enter your Rx info (i.e., brand/generic, form, dosage, quantity) to find the most accurate price of Lyllana with SingleCare near you.

How much does Lyllana cost without insurance?

The retail Lyllana price averages $210.30 per 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box. With a SingleCare discount card, purchase generic Lyllana for as little as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box.

How much does Lyllana cost with insurance?

Lyllana is sometimes covered by health insurance, sometimes not. When it is not covered, the insurance plan typically covers generic estradiol patches or other brands. For some insurance plans, the out-of-pocket cost for Lyllana could be high. If insurance coverage or cost is a problem, use a SingleCare Lyllana coupon without insurance to purchase generic Lyllana for as low as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box. 

Does Medicare cover Lyllana?

Most Medicare Part D drug plans cover Lyllana, but coverage varies between insurance providers. Lyllana is usually placed in higher-cost copay tiers, so the out-of-pocket cost may be high. If cost or coverage is an issue, a SingleCare Lyllana coupon may be the cheapest option.

Does Medicaid cover Lyllana?

Some Medicaid plans cover Lyllana, but many either don’t cover Lyllana or they consider it a nonpreferred drug. Nevertheless, all state Medicaid plans cover generic estradiol transdermal systems. If Medicaid Lyllana coverage is a problem, use a Lyllana coupon from SingleCare instead of Medicaid to purchase Lyllana at a discount price.

Is there a generic for Lyllana? 

Women can purchase generic estradiol patches that work the same way and deliver the same daily dose as Lyllana (0.025 mg/day, 0.0375 mg/day, 0.05 mg/day, 0.075 mg/day, and 0.1 mg/day). Health insurance is more likely to cover generic Lyllana. With a SingleCare prescription discount card, the lowest price for estradiol patches is $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box.

Ways to save on Lyllana

Uninsured women have a number of ways to save on Lyllana and estrogen hormone replacement therapy, including:

  • Using SingleCare’s discount program along with SingleCare’s bonus loyalty program to save money 

  • Switching to a generic estradiol transdermal system

  • Switching to a different type of estradiol medication, such as oral estradiol

  • Enrolling in Medicaid or Medicare Extra Help if the eligibility requirements can be met

  • Visiting a 340B provider or community health clinic that could sell Lyllana at a discount price

  • Applying to a patient assistance program that supplies discounted prescription drugs

  • Comparing pharmacy prices to find the best price

If switching medications looks like the best option, get medical advice from a healthcare professional about the options.

Is there a cheaper alternative to Lyllana?

For estradiol patches, there are cheaper brand-name versions, such as Dotti. But the cheapest alternative is to purchase a generic estradiol transdermal system. With a SingleCare prescription discount card, generic Lyllana could cost as little as $43.88 for 1, 1 box (8 twice weekly patches), 0.05mg/24 hr box.

The cheapest medication options for hormone replacement therapy are generic estradiol tablets or generic estradiol topical gels. Other formats, such as injections, are more expensive. Effectiveness, side effects, and safety may vary based on the format, so get medical advice from a healthcare professional before switching.

How to use SingleCare for Lyllana

You can use SingleCare coupons at most national pharmacies and grocery stores, such as Walgreens, Kroger, Walmart, CVS, Safeway, and more. Just text, email, print, or save your free Lyllana coupon to your mobile wallet and show a pharmacist at checkout. 

Where are Lyllana coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

Subscribe to our savings newsletter

Health education, drug info, wellness & more

By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.