What is Anucort-HC? Uses, warnings & side effects

Updated Jul 11, 2025  •  Published Dec 30, 2020

Anucort HC is a prescription suppository that treats hemorrhoids and other inflammatory conditions of the anus and rectum. Its active ingredient is hydrocortisone, a topical corticosteroid that reduces swelling. Anucort HC is used two or three times a day for short periods (two to six weeks).

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Anucort-HC overview

BRAND NAMES:

  • Anucort-HC

Generic Names:

  • Hydrocortisone acetate

Uses:

  • Treats inflammation of the rectum and anus due to hemorrhoids, proctitis, ulcerative colitis, and similar inflammatory conditions

Therapeutic Classes:

  • Topical corticosteroid, anti-inflammatory, anti-hemorrhoidal agent

Forms:

  • Suppository

How it’s taken:

  • Into the rectum

What is Anucort-HC used for?

Anucort-HC is used to treat inflamed hemorrhoids and radiation-induced proctitis. It is also used along with other drugs for ulcerative colitis, cryptitis, and other inflammatory conditions involving the rectum or anus.

What form(s) does Anucort-HC come in?

  • Suppository 

    • 25 mg

What are common Anucort-HC dosages?

  • For inflammatory conditions of the rectum or anus: 25 mg (one suppository) inserted into the rectum twice daily for two weeks

  • For more severe inflammatory conditions of the rectum or anus: 25 mg (one suppository) inserted into the rectum three times daily for six to eight weeks

Anucort-HC images - What does Anucort-HC look like?

  • Anucort-HC
    12 suppository box

  • Anucort-HC
    24 suppository box

How to take Anucort-HC

  • Follow all the prescriber’s instructions.

  • Doses are inserted either twice daily or three times daily.

  • For twice daily dosing, insert a suppository once in the morning and once at night.

    • Detach one suppository from the strip.

    • To remove the suppository, hold it with the pointed end up.

    • Separate the tabs at the top and pull downwards for almost the full length of the suppository.

    • Gently remove the suppository. Only handle the suppository when you’re ready to insert it because it can easily melt.

    • Insert the pointed end into the anus and gently push the suppository into the rectum.

  • Store the suppositories in their foil wrap at room temperature. 

    • Keep this medicine away from heat. 

    • Do not freeze.

What to do if you miss a dose of Anucort-HC

  • Ask the prescriber how to manage a missed dose.

  • Do not insert two suppositories to make up for a missed dose.

Anucort-HC contraindications - Who shouldn't take Anucort-HC?

  • This medicine is not right for everyone. 

  • Do not use it if you have had an allergic reaction to hydrocortisone.

Anucort-HC warnings

  • Tell any doctor or other healthcare provider who treats you that you are using this medicine.

  • Keep all appointments with the prescriber.

  • Tell the prescriber if you are pregnant, breastfeeding, or have an active infection.

    • Anucort treatment may need to stop if an infection cannot be controlled by medications.

  • Anucort HC should only be used if a healthcare professional has performed a proctological examination.

  • Anucort HC may increase the risk of infections. If you experience symptoms of an infection, talk to your prescriber or other healthcare provider.

  • Anucort HC rarely causes serious side effects other than allergic reactions. 

    • Contact the prescriber if any less serious side effect worsens or doesn’t go away. 

  • Anucort HC may stain fabrics. Take necessary precautions.

Anucort-HC interactions & what to avoid when taking Anucort-HC

  • Tell the prescriber about any drug that’s being taken, particularly other rectal medications or products.

  • As a topical medication, Anucort HC minimally interacts with other medications.

    • The Anucort HC prescribing information does not have any warnings or precautions about possible drug interactions.

Anucort-HC side effects - How does Anucort-HC make you feel?

Serious side effects

Talk to a doctor if you notice any signs or symptoms of a possible serious side effect, including:

  • Rectal bleeding 

  • Blood in the stools

  • Changes in mood or behavior

  • Heart rhythm abnormalities

  • Weakness, tiredness, nausea, vomiting, weight loss

  • Eye pain, vision changes

  • Infection: Sore throat, fever, painful urination, persistent anal irritation or redness

  • Allergic reaction: rash, itching, swelling of the face, tongue, or throat, trouble breathing

Less serious side effects

  • Rectal irritation, burning, or itching

  • Rectal or anal dryness

  • Folliculitis

  • Skin color changes

Sources:

Anucort-HC News & Research

How to get rid of hemorrhoids fast

Hydrocortisone vs. cortisone: Differences, similarities, and which is better for you

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