What is Azathioprine Sodium: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Azathioprine Sodium overview

BRAND NAMES:

Generic Names:

  • Azathioprine Sodium

Uses:

  • Prevents rejection of a transplanted kidney by suppressing the immune system. Also treats rheumatoid arthritis.

Therapeutic Classes:

  • Antirheumatic, Cytotoxic

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Azathioprine Sodium used for?

What form(s) does Azathioprine Sodium come in

  • Injectable

What are common Azathioprine Sodium doses?

  • Solution Reconstituted 100MG

Common Azathioprine Sodium prescriptions

  • azaTHIOprine Sodium
    100mg solution reconstituted

How to take Azathioprine Sodium

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any questions about this, talk to your doctor.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any questions about this, talk to your doctor.

  • Injection routeA nurse or other health provider will give you this medicine.

What to do if you miss a dose of Azathioprine Sodium

Azathioprine Sodium contraindications

  • This medicine is not right for everyone. You should not receive this medicine if you had an allergic reaction to azathioprine, or if you are pregnant.

Azathioprine Sodium warnings

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

  • Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, stomach or bowel problems (including Crohn's disease, ulcerative colitis), blood or bone marrow problems, or any type of infection.

  • This medicine may cause the following problems:Increased risk of cancer (including skin cancer, solid tumors, leukemia, or lymphoma)Increased risk of infection, including progressive multifocal leukoencephalopathy (PML)Serious bowel allergic reactions

  • Use sunscreen with a sun protection factor (SPF) of at least 15 when you are outdoors. Wear protective clothing and hats, and stay out of direct sunlight between the hours of 10 am and 3 pm Avoid sunlamps and tanning beds.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Azathioprine Sodium interactions

  • Do not use this medicine if you have received other medicines for arthritis in the past, including chlorambucil, cyclophosphamide, or melphalan.

  • Some medicines can affect how azathioprine works. Tell your doctor if you are also using allopurinol, cotrimoxazole, febuxostat, mercaptopurine, mesalamine, olsalazine, ribavirin, sulfasalazine, a blood pressure medicine (including ACE inhibitors), or a blood thinner (including warfarin).

  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

  • Use sunscreen with a sun protection factor (SPF) of at least 15 when you are outdoors. Wear protective clothing and hats, and stay out of direct sunlight between the hours of 10 a.m. and 3 p.m. Avoid sunlamps and tanning beds.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Azathioprine Sodium side effects

Serious Side Effects

  • Lightheadedness, dizziness, or fainting

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Fever, chills, cough, sore throat, body aches

  • Unusual bleeding, bruising, or weakness

  • Sores on the skin, swollen glands, abnormal skin growths

  • Severe stomach pain, nausea, vomiting, or diarrhea

Less Serious Side Effects

  • Hair loss

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

  • Sores or white patches on your lips, mouth, or throat

  • Joint or muscle pain

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