What is Besponsa: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Feb 14, 2024

Besponsa overview

BRAND NAMES:

  • Besponsa

Generic Names:

  • Besponsa

Uses:

  • Treats acute lymphoblastic leukemia (ALL).

Therapeutic Classes:

  • Antineoplastic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Besponsa used for?

What form(s) does Besponsa come in

  • Injectable

What are common Besponsa doses?

  • Solution Reconstituted 0.9mg

Common Besponsa prescriptions

  • Besponsa
    0.9mg solution reconstituted

How to take Besponsa

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • You may receive other medicines (including allergy medicine, fever medicine, steroids) before starting treatment with this medicine. You may need to stay at the hospital or clinic for at least 1 hour after you receive this medicine to make sure you do not have any serious side effects.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

What to do if you miss a dose of Besponsa

Besponsa contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to inotuzumab ozogamicin, or if you are pregnant or breastfeeding.

Besponsa warnings

  • This medicine may cause the following problems:Liver problems (including hepatic veno-occlusive disease or sinusoidal obstruction syndrome)Infusion-related reactionsChanges in heart rhythm

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Tell your doctor if you have liver disease, electrolyte imbalance, or a history of heart rhythm problems (including QT prolongation).

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • Do not breastfeed during treatment with this medicine and for at least 2 months after the last dose.

  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

  • This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use an effective form of birth control during treatment with this medicine and for at least 8 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for at least 5 months after the last dose. Tell your doctor if you have had stem cell transplant.

Besponsa interactions

  • Some medicines can affect how inotuzumab ozogamicin works. Tell your doctor if you are also using medicine for heart rhythm problems.

Besponsa side effects

Serious Side Effects

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Fever, chills, headache, cough, sore throat, body aches

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Warmth or redness in your face, neck, arms, or upper chest

  • Fast, pounding, or uneven heartbeat

  • Lightheadedness, dizziness, fainting

Less Serious Side Effects

  • Headache

  • Diarrhea, constipation

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

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