What is Bupivacaine Hcl (Pf): Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Bupivacaine Hcl (Pf) overview

BRAND NAMES:

  • Bupivacaine HCl Novaplus, Bupivacaine Spinal, Marcaine, Marcaine HCl, Marcaine Spinal, Sensorcaine, Sensorcaine-MPF, Sensorcaine-MPF, Active Injection Kit LM-Dep-2, Active Injection Kit M-1, BL Injection Kit, BT Injection Kit, Bupivacaine HCl Novaplus, Bupivacaine Spinal, Bupivilog Kit

Generic Names:

  • Bupivacaine Hcl (Pf)

Uses:

  • Numbs an area of your body during surgery or other procedures, including childbirth, or dental work. This medicine is a local anesthetic.

Therapeutic Classes:

  • Anesthetic, Local

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Bupivacaine Hcl (Pf) used for?

What form(s) does Bupivacaine Hcl (Pf) come in

  • Injectable

What are common Bupivacaine Hcl (Pf) doses?

  • Vial 10ML of 0.25%

  • Vial 30ML of 0.25%

  • Vial 10ML of 0.5%

  • Vial 30ML of 0.5%

  • Vial 10ML of 0.75%

  • Vial 30ML of 0.75%

Common Bupivacaine Hcl (Pf) prescriptions

  • BUPivacaine HCl (PF)
    10ml of 0.25% vial

  • BUPivacaine HCl (PF)
    10ml of 0.5% vial

  • BUPivacaine HCl (PF)
    10ml of 0.75% vial

  • BUPivacaine HCl (PF)
    30ml of 0.25% vial

  • BUPivacaine HCl (PF)
    30ml of 0.5% vial

  • BUPivacaine HCl (PF)
    30ml of 0.75% vial

How to take Bupivacaine Hcl (Pf)

  • A nurse or other trained health professional will give you this medicine in a medical facility. It is sometimes given through a catheter placed into your lower back for an epidural or a spinal block. You may also receive the injection into your rib cage, chest, or other body areas. This medicine may also be injected directly into your gums for dental work.

  • Injection routeA nurse or other health provider will give you this medicine.

  • A nurse or other trained health professional will give you this medicine in a medical facility. It is sometimes given through a catheter placed into your lower back for an epidural or a spinal block. You may also receive the injection into your rib cage, chest, or other body areas. This medicine may also be injected directly into your gums for dental work.

  • Injection routeA nurse or other health provider will give you this medicine.

What to do if you miss a dose of Bupivacaine Hcl (Pf)

Bupivacaine Hcl (Pf) contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to bupivacaine or similar medicines, or if you have severe bleeding, low blood pressure, any type of infection, heart rhythm problems, or an infection at the injection site.

Bupivacaine Hcl (Pf) warnings

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, blood or blood clotting problems (including methemoglobinemia), asthma, diabetes, seizures, myasthenia gravis, thyroid problems, high blood pressure, low blood pressure, lasting back pain, arthritis, spinal problems, lung or breathing problems, G6PD, or mental illness.

  • This medicine may cause the following problems:Methemoglobinemia (blood disorder)Chondrolysis (a bone or joint problem)Low blood pressureHyperthermia (a dangerous increase in body temperature)

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • This medicine should cause numbness only to the area where it is injected. It is not meant to cause you to fall asleep or become unconscious.

  • You may experience temporary loss of sensation and movement, usually in the lower half of your body, if you receive this medicine into your lower back (epidural).

  • If you are receiving this medicine as an epidural to ease labor pains, it may take longer than normal for you to push your baby out. It is also possible that the baby may have unwanted effects after birth (including sleepiness, slow responses). Talk to your doctor if you have questions about how this medicine might affect your baby.

Bupivacaine Hcl (Pf) interactions

  • Some medicines can affect how bupivacaine works. Tell your doctor if you are taking any of the following: Acetaminophen, chloroquine, metoclopramide, primaquine, quinine, sulfasalazineBlood pressure medicine (including atenolol, doxazosin, lisinopril, metoprolol, terazosin)Cancer medicine (including cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase)Ergot medicine or other medicines for headaches or migrainesMedicine to treat depression (including an MAO inhibitor, tricyclic antidepressant)Medicine to treat seizures (including phenobarbital, phenytoin, sodium valproate)Nitrate or nitrite medicine (including nitric oxide, nitroglycerin, nitroprusside, nitrous oxide)Phenothiazine medicine (including chlorpromazine, promethazine)

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • This medicine should cause numbness only to the area where it is injected. It is not meant to cause you to fall asleep or become unconscious.

  • It may be easier to hurt yourself while your treated body area is still numb. Be careful to avoid injury until you have regained all the feeling and are no longer numb.

  • If you are receiving this medicine as an epidural to ease labor pains, it may take longer than normal for you to push your baby out. It is also possible that the baby may have unwanted effects after birth (sleepiness, slow responses). Talk to your doctor if you have questions about how this medicine might affect your baby.

Bupivacaine Hcl (Pf) side effects

Serious Side Effects

  • Nausea, vomiting, chills, metallic taste in your mouth

  • Bone or joint pain or stiffness, inability to move

  • Chest pain, fast, pounding, slow, or uneven heartbeat, trouble breathing

  • Seizures, shivering, shaking, or tremors

  • Lightheadedness, dizziness, or fainting

  • Pale, gray, or blue lips, nails, or skin, dark urine, headache, unusual tiredness or weakness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Anxiety, depression, restlessness, drowsiness, ringing in your ears, blurred vision

Less Serious Side Effects

  • Headache, back pain

  • Pain, redness, or swelling where the needle was placed

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