Letrozole is a generic prescription medicine used to treat breast cancer in postmenopausal women. The average retail price of Letrozole is around $130.94 per 10, 2.5mg tablets. SingleCare can help you save on the total cost with a free coupon for Letrozole. You may be able to purchase Letrozole for our lowest price of $5.63 for 10, 2.5mg tablets at participating pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 08/03/2026
Letrozole is a generic prescription medicine used to treat breast cancer in postmenopausal women. The average retail price of Letrozole is around $130.94 per 10, 2.5mg tablets. SingleCare can help you save on the total cost with a free coupon for Letrozole. You may be able to purchase Letrozole for our lowest price of $5.63 for 10, 2.5mg tablets at participating pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Letrozole Retail Price | Letrozole SingleCare Price |
|---|---|---|
| CVS Pharmacy | $107.05 | $3.74 |
| Walmart | $45.70 | $3.00 |
| Walgreens | $132.49 | $31.86 |
| Kroger Pharmacy | $25.28 | $6.00 |
| Albertsons Pharmacy | $188.00 | $24.80 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Letrozole is a generic prescription medicine used to treat breast cancer in postmenopausal women. The average retail price of Letrozole is around $130.94 per 10, 2.5mg tablets. SingleCare can help you save on the total cost with a free coupon for Letrozole. You may be able to purchase Letrozole for our lowest price of $5.63 for 10, 2.5mg tablets at participating pharmacies.
Letrozole costs $5.63 for 10, 2.5mg tablets with a free Letrozole coupon from SingleCare. But, you could pay even less depending on your prescription details. Use the dropdown menu above to enter your Rx info (i.e., brand/generic, form, dosage, quantity) to get the most accurate prices of Letrozole with SingleCare at a pharmacy near you.
Letrozole may cost around $130.94 per 10, 2.5mg tablets or more if you do not have insurance coverage. Using a SingleCare Letrozole savings card can help you save on your prescription medication. Pay a lower cash price by using a prescription discount card from SingleCare at neighborhood drugstores.
Your out-of-pocket cost of Letrozole with insurance will depend on the type of plan you have and your level of coverage. The plans offered by various drug insurance companies may have different copays for Letrozole. You can pinpoint your exact Letrozole cost by visiting your local pharmacy and asking for assistance. You may be able to save even more on your Letrozole prescription by using SingleCare's Letrozole coupons. Letrozole prices are as low as $5.63 for 10, 2.5mg tablets when you use SingleCare.
Letrozole is currently covered by most Medicare Part D and Medicare Advantage plans. You can also save on this drug by using a SingleCare savings card. Find pricing as low as $5.63 for 10, 2.5mg tablets of Letrozole when you use your SingleCare discount card at participating pharmacies.
SingleCare can help you save on your Letrozole prescription. Use our free Letrozole coupon and pay a reduced price of $5.63 for 10, 2.5mg tablets of Letrozole.
Drug prices vary by pharmacy. To ensure you’re getting the best deal on each refill, use SingleCare to compare Letrozole prices at pharmacies near you.
Letrozole is a generic prescription medication. The brand-name version of this medication is Femara.
Letrozole is an FDA-approved generic prescription drug used to treat hormone receptor-positive breast cancer in postmenopausal women. As part of a class of drugs called aromatase inhibitors, it works by blocking the enzyme responsible for converting androgens (like testosterone) to estrogen. Letrozole helps lower estrogen levels in postmenopausal women. This effect may slow the growth and spread of certain types of breast tumors that need estrogen to grow in the body.
Letrozole comes in the form of 2.5 mg oral tablets, which may be taken with or without food. Follow all directions listed on your prescription label when taking this medication, or talk to your doctor for their medical advice on how to use this medication. Letrozole should not be used if you are pregnant, as it can cause harm to an unborn baby.
Letrozole is rarely prescribed to women before menopause. This is because premenopausal women still get estrogen from their ovaries. Therefore, Letrozole would not be an effective cancer treatment when used alone in pre- or perimenopausal women. However, Letrozole can be used off-label as an ovulation induction agent, particularly in patients with polyendocrine metabolic ovarian syndrome (PMOS), formerly known as polycystic ovary syndrome.
Tell your doctor if you have had liver disease, osteoporosis, high cholesterol, or if you have used tamoxifen. Your doctor will need to take this into account when assessing whether this medication is right for you.
Letrozole, or generic Femara, is usually prescribed as a 2.5 mg oral tablet once daily.
Common side effects resulting from the use of Letrozole may include hot flashes, joint pain (arthralgia), flushing of the skin, swelling in the hands or feet (edema), headache, dizziness, increased sweating, bone pain, and fatigue. Talk to your doctor or pharmacist if you experience any of these effects, especially if they persist or worsen.
Letrozole may cause a decrease in bone mineral density, which can lead to an increased risk of bone fractures. You may need to undergo frequent monitoring to measure the severity of this side effect. Your doctor may recommend that you change your dose or stop using this medication based on the results of these tests.
Ask your doctor or healthcare professional for more drug information on Letrozole. This is not a complete list of side effects or drug interactions.
SingleCare coupons are accepted at most national pharmacies and grocers, i.e., Walgreens, Kroger, Walmart, CVS, Safeway, and more. Text, email, print, or save your free Letrozole coupon to your digital wallet and show your pharmacist at the counter.
Madeline Remelius, Pharm.D., BCPS, graduated with her Doctor of Pharmacy degree from St. Louis College of Pharmacy at the University of Health Sciences and Pharmacy in St. Louis in 2021, then went on to complete a PGY1 Pharmacy Practice Residency at Sarasota Memorial Hospital in Sarasota, Florida. Dr. Remelius currently works as a clinical pharmacist in Sarasota, Florida, caring for both adult and pediatric patients. Dr. Remelius has developed a true passion for ensuring the well-being of patients through the safe and effective use of medications and providing evidence-based recommendations and guidance to healthcare teams, ultimately improving patient outcomes and promoting medication safety.
...SingleCare is accepted at most national pharmacies and grocers, including the following:
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved