Letrozole Coupons & Prices

Femara

Letrozole is a generic prescription medicine used to treat breast cancer in postmenopausal women. The average retail price of Letrozole is around $130.94 per 10, 2.5mg tablets. SingleCare can help you save on the total cost with a free coupon for Letrozole. You may be able to purchase Letrozole for our lowest price of $5.63 for 10, 2.5mg tablets at participating pharmacies.

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Letrozole coupon at Kroger Pharmacy
$8.63
$ 5.63
$3 off with signupwith signup

Show this free card to your pharmacist.

This coupon is not insurance.
Letrozole coupon at Harris Teeter Pharmacy
$8.63
$ 5.63
$3 off with signupwith signup
Letrozole coupon at Walmart Neighborhood Market Pharmacy
$12.40
$ 9.40
$3 off with signupwith signup
Letrozole coupon at Walmart Pharmacy
$12.40
$ 9.40
$3 off with signupwith signup
Letrozole coupon at Food Lion Pharmacy
$ 9.55
Letrozole coupon at Publix Pharmacy
$ 19.50
$ 20.99
$25.04
$ 22.04
$3 off with signupwith signup
$36.75
$ 33.75
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 08/03/2026

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About Letrozole

Letrozole is a generic prescription medicine used to treat breast cancer in postmenopausal women. The average retail price of Letrozole is around $130.94 per 10, 2.5mg tablets. SingleCare can help you save on the total cost with a free coupon for Letrozole. You may be able to purchase Letrozole for our lowest price of $5.63 for 10, 2.5mg tablets at participating pharmacies.

Letrozole Price History & Information

Price History for Letrozole (Generic) & Femara (Brand)

10 count, Tablet, 2.5mg

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Letrozole (Generic) & Femara (Brand)

10 count, Tablet, 2.5mg
PharmacyLetrozole Retail PriceLetrozole SingleCare Price
CVS Pharmacy$107.05$3.74
Walmart$45.70$3.00
Walgreens$132.49$31.86
Kroger Pharmacy$25.28$6.00
Albertsons Pharmacy$188.00$24.80

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Letrozole

Letrozole is a generic prescription medicine used to treat breast cancer in postmenopausal women. The average retail price of Letrozole is around $130.94 per 10, 2.5mg tablets. SingleCare can help you save on the total cost with a free coupon for Letrozole. You may be able to purchase Letrozole for our lowest price of $5.63 for 10, 2.5mg tablets at participating pharmacies.

Letrozole FAQs

Medically reviewed by Madeline RemeliusPharm.D., BCPS
Licensed Pharmacist

How much is Letrozole with SingleCare?

Letrozole costs $5.63 for 10, 2.5mg tablets with a free Letrozole coupon from SingleCare.  But, you could pay even less depending on your prescription details. Use the dropdown menu above to enter your Rx info (i.e., brand/generic, form, dosage, quantity) to get the most accurate prices of Letrozole with SingleCare at a pharmacy near you.

How much does Letrozole cost without insurance?

Letrozole may cost around $130.94 per 10, 2.5mg tablets or more if you do not have insurance coverage. Using a SingleCare Letrozole savings card can help you save on your prescription medication. Pay a lower cash price by using a prescription discount card from SingleCare at neighborhood drugstores.

How much does Letrozole cost with insurance?

Your out-of-pocket cost of Letrozole with insurance will depend on the type of plan you have and your level of coverage. The plans offered by various drug insurance companies may have different copays for Letrozole. You can pinpoint your exact Letrozole cost by visiting your local pharmacy and asking for assistance. You may be able to save even more on your Letrozole prescription by using SingleCare's Letrozole coupons. Letrozole prices are as low as $5.63 for 10, 2.5mg tablets when you use SingleCare.

Does Medicare cover Letrozole and how much does it cost?

Letrozole is currently covered by most Medicare Part D and Medicare Advantage plans. You can also save on this drug by using a SingleCare savings card. Find pricing as low as $5.63 for 10, 2.5mg tablets of Letrozole when you use your SingleCare discount card at participating pharmacies.

How to save on Letrozole

SingleCare can help you save on your Letrozole prescription. Use our free Letrozole coupon and pay a reduced price of $5.63 for 10, 2.5mg tablets of Letrozole.

Drug prices vary by pharmacy. To ensure you’re getting the best deal on each refill, use SingleCare to compare Letrozole prices at pharmacies near you.

Is there a brand name of Letrozole?

Letrozole is a generic prescription medication. The brand-name version of this medication is Femara.

What is Letrozole?

Letrozole is an FDA-approved generic prescription drug used to treat hormone receptor-positive breast cancer in postmenopausal women. As part of a class of drugs called aromatase inhibitors, it works by blocking the enzyme responsible for converting androgens (like testosterone) to estrogen. Letrozole helps lower estrogen levels in postmenopausal women. This effect may slow the growth and spread of certain types of breast tumors that need estrogen to grow in the body.

Letrozole comes in the form of 2.5 mg oral tablets, which may be taken with or without food. Follow all directions listed on your prescription label when taking this medication, or talk to your doctor for their medical advice on how to use this medication. Letrozole should not be used if you are pregnant, as it can cause harm to an unborn baby. 

Letrozole is rarely prescribed to women before menopause. This is because premenopausal women still get estrogen from their ovaries. Therefore, Letrozole would not be an effective cancer treatment when used alone in pre- or perimenopausal women. However, Letrozole can be used off-label as an ovulation induction agent, particularly in patients with polyendocrine metabolic ovarian syndrome (PMOS), formerly known as polycystic ovary syndrome.  

Tell your doctor if you have had liver disease, osteoporosis, high cholesterol, or if you have used tamoxifen. Your doctor will need to take this into account when assessing whether this medication is right for you.

What doses of Letrozole are available?

Letrozole, or generic Femara, is usually prescribed as a 2.5 mg oral tablet once daily. 

What are the side effects of Letrozole?

Common side effects resulting from the use of Letrozole may include hot flashes, joint pain (arthralgia), flushing of the skin, swelling in the hands or feet (edema), headache, dizziness, increased sweating, bone pain, and fatigue. Talk to your doctor or pharmacist if you experience any of these effects, especially if they persist or worsen.

Letrozole may cause a decrease in bone mineral density, which can lead to an increased risk of bone fractures. You may need to undergo frequent monitoring to measure the severity of this side effect. Your doctor may recommend that you change your dose or stop using this medication based on the results of these tests.

Ask your doctor or healthcare professional for more drug information on Letrozole. This is not a complete list of side effects or drug interactions.

How to use SingleCare for Letrozole

SingleCare coupons are accepted at most national pharmacies and grocers, i.e., Walgreens, Kroger, Walmart, CVS, Safeway, and more. Text, email, print, or save your free Letrozole coupon to your digital wallet and show your pharmacist at the counter.

Medically reviewed by Madeline RemeliusPharm.D., BCPS
Licensed Pharmacist

Madeline Remelius, Pharm.D., BCPS, graduated with her Doctor of Pharmacy degree from St. Louis College of Pharmacy at the University of Health Sciences and Pharmacy in St. Louis in 2021, then went on to complete a PGY1 Pharmacy Practice Residency at Sarasota Memorial Hospital in Sarasota, Florida. Dr. Remelius currently works as a clinical pharmacist in Sarasota, Florida, caring for both adult and pediatric patients. Dr. Remelius has developed a true passion for ensuring the well-being of patients through the safe and effective use of medications and providing evidence-based recommendations and guidance to healthcare teams, ultimately improving patient outcomes and promoting medication safety.

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Where are Letrozole coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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