What is Carbidopa-Levodopa-Entacapone: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Carbidopa-Levodopa-Entacapone overview

BRAND NAMES:

  • Stalevo 75, Stalevo 100, Stalevo 125, Stalevo 150, Stalevo 200, Stalevo 50, Stalevo 75, Stalevo 50

Generic Names:

  • Carbidopa-Levodopa-Entacapone

Uses:

  • Treats symptoms of Parkinson disease.

Therapeutic Classes:

  • Antiparkinsonian

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Carbidopa-Levodopa-Entacapone used for?

Carbidopa-Levodopa-Entacapone is a combination medication that is used to treat the symptoms of Parkinson’s disease, including shakiness, stiffness, and difficulty moving. Levodopa is a form of dopamine that is usually deficient in patients with Parkinson’s disease. Carbidopa makes levodopa available for transport to the brain and decreases some of the side effects of Levodopa. Entacapone inhibits the enzyme that breaks down levodopa, thus increasing the levels and presence of levodopa in the body. Carbidopa-Levodopa-Entacapone is indicated for use by adults and is available as a tablet.

What form(s) does Carbidopa-Levodopa-Entacapone come in

  • Tablet

What are common Carbidopa-Levodopa-Entacapone doses?

  • Tablet 50-200-200MG

  • Tablet 25-100-200MG

  • Tablet 37.5-150-200MG

  • Tablet 31.25-125-200MG

  • Tablet 12.5-50-200MG

  • Tablet 18.75-75-200MG

Common Carbidopa-Levodopa-Entacapone prescriptions

  • Carbidopa-Levodopa-Entacapone
    12.5-50-200mg tablet

  • Carbidopa-Levodopa-Entacapone
    18.75-75-200mg tablet

  • Carbidopa-Levodopa-Entacapone
    25-100-200mg tablet

  • Carbidopa-Levodopa-Entacapone
    31.25-125-200mg tablet

  • Carbidopa-Levodopa-Entacapone
    37.5-150-200mg tablet

  • Carbidopa-Levodopa-Entacapone
    50-200-200mg tablet

How to take Carbidopa-Levodopa-Entacapone

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Swallow the tablet whole. Do not crush, chew, or break it.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Swallow the tablet whole. Do not crush, chew, or break it.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

What to do if you miss a dose of Carbidopa-Levodopa-Entacapone

Carbidopa-Levodopa-Entacapone contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to carbidopa, levodopa, or entacapone, or if you have narrow-angle glaucoma.

Carbidopa-Levodopa-Entacapone warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, diabetes, glaucoma, low blood pressure, lung disease, a sleep disorder, a history of stomach ulcers, or a history of depression or mental illness.

  • This medicine may cause the following problems:Low blood pressureDyskinesia (trouble controlling movements)Unusual changes in mood or behavior, compulsive behaviors, hallucinationsPossible increased risk for skin cancer

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Tell your doctor if your Parkinson symptoms come back between doses.

  • This medicine may make you dizzy or drowsy. It may even cause you to fall asleep without warning. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Stand up slowly.

  • This medicine may cause your saliva, sweat, or urine to become dark red, brown, or black. This is nothing to worry about, but it could stain your clothes.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Twitching or muscle movements you cannot control (either new or worse than usual)

Carbidopa-Levodopa-Entacapone interactions

  • Do not take this medicine if you are also using phenelzine or tranylcypromine.

  • Some foods and medicines can affect how this medicine works. Tell your doctor if you are taking any of the following: Apomorphine, cholestyramine, dobutamine, dopamine, epinephrine, isoniazid, isoproterenol, methyldopa, metoclopramide, norepinephrine, papaverine, phenytoin, probenecid, risperidone, selegiline, or warfarinAn antibiotic (such as ampicillin, chloramphenicol, erythromycin, rifampicin), blood pressure medicine, medicine to treat depression or mental illness, a phenothiazine medicine, or vitamin supplements that contain iron

  • High-protein foods can affect how your body absorbs this medicine. Talk to your doctor before you make any changes to your diet.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • This medicine may make you dizzy or drowsy. It may even cause you to fall asleep without warning. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Stand up slowly.

  • This medicine may cause your saliva, sweat, or urine to become dark red, brown, or black. This is nothing to worry about, but it could stain your clothes.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Carbidopa-Levodopa-Entacapone side effects

Serious Side Effects

  • Seeing or hearing things that are not really there

  • Twitching or muscle movements you cannot control (either new or worse than usual)

  • Fever, sweating, muscle stiffness, uneven heartbeat

  • Lightheadedness, dizziness, fainting

  • Severe diarrhea

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Confusion, unusual changes in mood or behaviors, behaviors you cannot control

  • Muscle pain, tenderness, or weakness

  • Skin changes or growths

  • Extreme sleepiness or drowsiness

Less Serious Side Effects

  • Discolored urine, sweat, or saliva

  • Mild diarrhea, nausea, or vomiting, stomach pain

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