What is Clotrimazole-Betamethasone? Uses, warnings & side effects

Your doctor will tell you how much medicine to use. Do not use more than directed.

Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Use this medicine only on your skin. 

• Do not get the medicine in your eyes, nose, or mouth.

• Do not use clotrimazole-betamethasone on your face, armpits, or inside the vagina.

• Rinse it off right away if it gets on a cut or scrape. 

Wash your hands with soap and water before and after you use this medicine.

How to apply clotrimazole-betamethasone cream:

• For athlete’s foot, gently massage a sufficient amount of the cream into the affected skin.

• For jock itch or ringworm, apply a thin layer of the cream to the affected area.

• Wash your hands when finished.

• Store the tube of cream at room temperature.

How to apply clotrimazole-betamethasone lotion:

• Shake the bottle well before applying a dose.

• Gently massage a sufficient amount of the lotion into the affected skin.

• Wash your hands when finished.

• Store the lotion bottle upright at room temperature.

Do not cover, wrap, or bandage the treated skin. 

• If using clotrimazole-betamethasone to treat jock itch, do not wear tight-fitting clothes over the treated area.

Use this medicine for the full duration of treatment prescribed even if the infection seems to go away. Do not miss any doses.

Do not use more than 45 grams of cream or 45 milliliters (mL) of lotion per week.

This medicine is not for long-term use. Do not use clotrimazole-betamethasone to treat jock itch and ringworm for more than 2 weeks or for more than 4 weeks to treat athlete’s foot. 

Apply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. 

Do not apply extra medicine to make up for a missed dose.

This medicine is not right for everyone. 

Do not use it if you have had an allergic reaction to clotrimazole, betamethasone, drugs similar to clotrimazole called imidazole antifungals, or drugs similar to betamethasone called corticosteroids.

Tell any doctor or other healthcare provider who treats you that you are using this medicine.

Your doctor may need to visit with you or do blood tests to monitor the effects of this medicine. Keep all appointments.

Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Though rare, clotrimazole-betamethasone cream or lotion may cause the following problems:

• Adrenal gland problems

• Cataracts

• Glaucoma

• High blood sugar

• Cushing’s syndrome (a condition caused by too much corticosteroids in the body)

Immediately stop using clotrimazole-betamethasone and contact a doctor if you notice vision changes such as blurred vision or eye pain.

If athlete’s foot does not improve after 1 week of treatment, or if ringworm or jock itch does not improve after 2 weeks of treatment, or if they get worse, check with your doctor.

Do not use this medicine on anyone younger than 17 years of age.

Do not use this medicine to treat diaper rash.

Keep clotrimazole-betamethasone out of the reach of children.

To avoid potentially hazardous drug interactions, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medications, and supplements you use before using clotrimazole-betamethasone.

Tell other healthcare providers you are using this medicine before they prescribe new medications.

Avoid using clotrimazole-betamethasone with other corticosteroids such as prednisone. This includes over-the-counter topical corticosteroids like hydrocortisone cream. Talk to the doctor before using such products.