What is Nystatin-Triamcinolone: Uses, Warnings & Interactions

Updated Jul 11, 2025  •  Published Dec 30, 2020

Nystatin/triamcinolone is a generic prescription topical drug that treats yeast infections of the skin. Nystatin is an antifungal drug that kills yeast, while triamcinolone is a topical corticosteroid that reduces itching and discomfort. Doses are applied to the skin twice daily.

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Nystatin-Triamcinolone overview

BRAND NAMES:

  • No brand-name versions

Generic Names:

  • Nystatin-triamcinolone

Uses:

  • Treats yeast infections of the skin (cutaneous candidiasis)

Therapeutic Classes:

  • Topical antifungal, topical corticosteroid

Forms:

  • Cream, ointment

How it’s taken:

  • On the skin

What is Nystatin-Triamcinolone used for?

Nystatin/triamcinolone is a combination drug that treats cutaneous candidiasis, a yeast infection of the skin.

What form(s) does Nystatin-Triamcinolone come in

  • Cream

    • 100,000 USP units of nystatin/0.1 mg triamcinolone per gram of cream

  • Ointment

    • 100,000 USP units of nystatin/0.1 mg triamcinolone per gram of cream

USP units measure the potency of nystatin to kill yeast.

What are common Nystatin-Triamcinolone doses?

  • For cutaneous candidiasis (yeast infection of the skin): Apply a thin film to the affected skin twice daily, once in the morning and once at night

Common Nystatin-Triamcinolone prescriptions

  • Nystatin-Triamcinolone
    15gm of 100000-0.1unit/gm-% tube

  • Nystatin-Triamcinolone
    30gm of 100000-0.1unit/gm-% tube

  • Nystatin-Triamcinolone
    60gm of 100000-0.1unit/gm-% tube

  • Nystatin-Triamcinolone
    15gm of 100000-0.1unit/gm-% tube of cream

  • Nystatin-Triamcinolone
    30gm of 100000-0.1unit/gm-% tube of cream

  • Nystatin-Triamcinolone
    60gm of 100000-0.1unit/gm-% tube of cream

  • Nystatin-Triamcinolone
    15gm of 100000-0.1unit/gm-% tube of ointment

  • Nystatin-Triamcinolone
    30gm of 100000-0.1unit/gm-% tube of ointment

  • Nystatin-Triamcinolone
    60gm of 100000-0.1unit/gm-% tube of ointment

How to take Nystatin-Triamcinolone

  • Follow all the prescriber’s instructions.

  • Use this medicine on the skin only.

    • Do not let it get in your eyes or mouth.

  • Apply the cream or ointment twice daily, once in the morning and once at night.

  • Wash your hands before and after applying a dose.

  • Apply a thin film of cream to the affected skin and rub it in gently.

    • Avoid getting any of this medicine on the skin surrounding the affected area.

    • Avoid tight-fitting diapers and plastic pants if this medicine is used on your child's diaper area.

  • Wear loose-fitting clothes over this medicine.

    • Do not put a bandage over the treated area unless instructed otherwise.

    • When used on an infant’s diaper area, avoid tight-fitting diapers or plastic pants.

  • If the medicine does not work after two to three weeks, call the prescriber.

What to do if you miss a dose of Nystatin-Triamcinolone

  • Do not miss any doses.

  • Ask the prescriber how to handle a missed dose.

  • Do not apply extra medicine to make up for a missed dose.

Nystatin-Triamcinolone contraindications

  • You should not use this medicine if you have ever had an allergic reaction to nystatin, triamcinolone, or any other product ingredient.

Nystatin-Triamcinolone warnings

  • Tell other healthcare providers who treat you that you are using this medicine.

  • Before starting this medicine, tell the healthcare provider if you are pregnant or breastfeeding. 

  • If you become pregnant while taking this medicine, tell the prescriber.

  • Using too much nystatin/triamcinolone or using it on large areas of the skin may cause adrenal gland problems.

  • Do not use this medicine for any other condition other than that for which it is prescribed.

  • Ask the healthcare provider how to prevent future yeast infections of the skin.

Nystatin-Triamcinolone interactions

  • Topical nystatin/triamcinolone does not have significant drug interactions.

Nystatin-Triamcinolone side effects

Report any adverse skin reactions to the prescriber.

Serious side effects

  • Allergic reaction: hives, swelling, trouble breathing, skin bumps, skin scaling

Less serious side effects

  • Burning

  • Itching

  • Skin irritation

  • Dryness

  • Break-out of acne (pimples)

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