What is Dacarbazine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Dacarbazine overview

BRAND NAMES:

Generic Names:

  • Dacarbazine

Uses:

  • Treats skin cancer and Hodgkin disease.

Therapeutic Classes:

  • Antineoplastic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Dacarbazine used for?

Dacarbazine is a cancer medication used to treat patients with melanoma, a form of skin cancer. This medication works by attacking the cells that are infected. This action blocks the cancer cells from growing and spreading in the body.

What form(s) does Dacarbazine come in

  • Injectable

What are common Dacarbazine doses?

  • Solution Reconstituted 200MG

Common Dacarbazine prescriptions

  • Dacarbazine
    100mg solution reconstituted

  • Dacarbazine
    200mg solution reconstituted

How to take Dacarbazine

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

What to do if you miss a dose of Dacarbazine

Dacarbazine contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to dacarbazine.

Dacarbazine warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver or kidney disease.

  • This medicine may cause the following problems: Bone marrow suppressionLiver problems

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Dacarbazine interactions

  • Dacarbazine can affect how some medicines work. Talk to your doctor before you get any vaccines, such as flu shots.

  • This medicine may cause the following problems: Bone marrow suppressionLiver problems

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Dacarbazine side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Dark urine, pale stools, stomach pain, yellow skin or eyes

  • Severe nausea or vomiting

  • Unusual bleeding, bruising, tiredness, or weakness

  • Mild nausea or vomiting

  • Pain, itching, or burning where the needle is placed

Less Serious Side Effects

  • Mild nausea or vomiting

  • Hair loss

  • Pain, itching, or burning where the needle is placed

  • Flushing in the face

  • Fever, chills, cough, or sore throat

  • Loss of appetite