What is Demeclocycline: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Demeclocycline overview

BRAND NAMES:

Generic Names:

  • Demeclocycline Hcl

Uses:

  • Treats infections caused by certain microorganisms.

Therapeutic Classes:

  • Antibiotic, Antiprotozoal

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Demeclocycline used for?

What form(s) does Demeclocycline come in

  • Tablet

What are common Demeclocycline doses?

  • Tablet 150MG

  • Tablet 300MG

Common Demeclocycline prescriptions

  • Demeclocycline HCl
    150mg tablet

  • Demeclocycline HCl
    300mg tablet

How to take Demeclocycline

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Oral routeIt is best to take this medicine on an empty stomach. Take your medicine one hour before you eat, or two hours after you eat.

  • Oral routeIt is best to take this medicine on an empty stomach. Take your medicine one hour before you eat, or two hours after you eat.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

What to do if you miss a dose of Demeclocycline

  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Demeclocycline contraindications

  • You should not use this medicine if you have had an allergic reaction to demeclocycline (Declomycin®) or any other tetracycline medicine. You should not use this medicine if you are pregnant or breast feeding.

Demeclocycline warnings

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

  • Stay out of the sunlight while you are taking this medicine. This includes avoiding sunlight that comes in through a window. Also be aware that even when the sky is cloudy, the UV light can still reach your skin. If you must be in the sun, wear clothing that covers all of your skin. This includes sunglasses, a hat, and gloves. You can also apply sunscreen that has a SPF (sun protection factor) of greater than 15.

  • Your doctor may need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.

  • You could get a serious sunburn while using this medicine. Carefully follow all instructions from your doctor.

  • Birth control pills may not work while you are using this medicine. To keep from getting pregnant, use another form of birth control. Other forms include condoms, a diaphragm, or contraceptive foam or jelly.

  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have kidney problems. Make sure your doctor knows if you have a history of diabetes insipidus (water diabetes), or if your skin or eyes are overly sensitive to sunlight. Make sure your doctor knows if you have syphilis.

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

Demeclocycline interactions

  • Your doctor may need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Stay out of the sunlight while you are taking this medicine. This includes avoiding sunlight that comes in through a window. Also be aware that even when the sky is cloudy, the UV light can still reach your skin. If you must be in the sun, wear clothing that covers all of your skin. This includes sunglasses, a hat, and gloves. You can also apply sunscreen that has a SPF (sun protection factor) of greater than 15.

  • You could get a serious sunburn while using this medicine. Carefully follow all instructions from your doctor.

  • Birth control pills may not work while you are using this medicine. To keep from getting pregnant, use another form of birth control. Other forms include condoms, a diaphragm, or contraceptive foam or jelly.

  • Make sure your doctor knows if you are also taking antacids containing aluminum, calcium, or magnesium. Examples of these medicines include aluminum carbonate, calcium carbonate, magnesium hydroxide, milk of magnesia, Basalgel®, Gaviscon®, Maalox®, Pepcid®, Pepto-Bismol®, Rolaids®, or Tums®.

  • Make sure your doctor knows if you are also using an anticoagulant medicine, such as warfarin (Coumadin®). Make sure your doctor knows if you are also using penicillin or penicillin-based medicine, such as amoxicillin (Amoxil®), amoxicillin/clavulanate (Augumentin®), Trimox®, or Veetids®.

Demeclocycline side effects

Serious Side Effects

  • Fever, chills, cough, sore throat, and body aches.

  • Feeling unusually tired or weak, or unusually thirsty.

  • Difficulty breathing or swallowing.

  • Chest pain.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Sores near your anus.

  • Skin rash or redness.

  • Ringing in your ears.

  • Pain, redness, or swelling of your tongue.

  • Nausea, vomiting, or diarrhea that may contain blood.

  • Loss of appetite.

  • Lightheadedness or dizziness.

  • Increase in how much or how often you urinate.

  • Headache.

Less Serious Side Effects

  • Increase in how much or how often you urinate.

  • Sores near your anus.

  • Blurred vision.

  • Feeling unusually tired or weak, or unusually thirsty.

  • Nausea, vomiting, or diarrhea that may contain blood.

  • Difficulty breathing or swallowing.

  • Skin rash or redness.

  • Ringing in your ears.

  • Headache.

  • Loss of appetite.

  • Lightheadedness or dizziness.

  • Fever, chills, cough, sore throat, and body aches.

  • Chest pain.

  • Pain, redness, or swelling of your tongue.

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