Desonide is an FDA-approved topical corticosteroid that is used to treat inflammation and itching caused by skin conditions, such as eczema, that respond to steroids. Desonide is a generic prescription drug. Desonide can also be found under the brand name of Desowen. The average retail price of Desonide topical cream is about $323.94 for 1, 60gm of 0.05% tube of cream of Desonide. You can save on your Desonide costs with a Desonide coupon from SingleCare. With our free coupon card, you could pay a reduced price of $26.46 for 1, 60gm of 0.05% tube of cream at participating pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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Desonide is an FDA-approved topical corticosteroid that is used to treat inflammation and itching caused by skin conditions, such as eczema, that respond to steroids. Desonide is a generic prescription drug. Desonide can also be found under the brand name of Desowen. The average retail price of Desonide topical cream is about $323.94 for 1, 60gm of 0.05% tube of cream of Desonide. You can save on your Desonide costs with a Desonide coupon from SingleCare. With our free coupon card, you could pay a reduced price of $26.46 for 1, 60gm of 0.05% tube of cream at participating pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Desonide Retail Price | Desonide SingleCare Price |
|---|---|---|
| CVS Pharmacy | $318.94 | $138.17 |
| Walmart | $149.02 | $87.49 |
| Walgreens | $324.00 | $134.67 |
| Kroger Pharmacy | $279.86 | $36.42 |
| Albertsons Pharmacy | $296.70 | $60.90 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Desonide is an FDA-approved topical corticosteroid that is used to treat inflammation and itching caused by skin conditions, such as eczema, that respond to steroids. Desonide is a generic prescription drug. Desonide can also be found under the brand name of Desowen. The average retail price of Desonide topical cream is about $323.94 for 1, 60gm of 0.05% tube of cream of Desonide. You can save on your Desonide costs with a Desonide coupon from SingleCare. With our free coupon card, you could pay a reduced price of $26.46 for 1, 60gm of 0.05% tube of cream at participating pharmacies.
The cost of Desonide without insurance is about $323.94 for 1, 60gm of 0.05% tube of cream of Desonide. You can save on your out-of-pocket costs for this medication with SingleCare. With our Desonide coupons you could pay a reduced price of $26.46 for 1, 60gm of 0.05% tube of cream for your Desonide prescription refill at any participating pharmacy including Target, Walmart, and Walgreens among others.
The cost of Desonide with insurance can vary by health insurance plan. The average retail price of Desonide is about $323.94 for 1, 60gm of 0.05% tube of cream of Desonide, but with a SingleCare copay, your price could be even less. When you use our prescription discount card you pay the reduced price of $26.46 for 1, 60gm of 0.05% tube of cream for your Desonide prescription refill. Our price may be less expensive than your insurance. You can ask your pharmacist to help you compare prices.
Some Medicare prescription plans may provide coverage for Desonide cream. However, if you are still looking to save on your out-of-pocket costs for Desonide, you can use SingleCare's free Desonide coupons. With our prescription savings card you could pay $26.46 for 1, 60gm of 0.05% tube of cream to refill your Desonide prescription. Visit your local pharmacy today and start saving.
Desonide is a generic prescription drug. Desowen is the brand-name version of Desonide.
Desonide is a topical corticosteroid that is used to treat inflammation and itching caused by skin conditions, such as eczema, that respond to steroids. Desonide is a generic prescription drug that is meant to be used for just two weeks unless directed by your doctor. Contact your doctor immediately if you begin to develop a bacterial, viral, or fungal skin infection or if your condition does not improve in two weeks while using Desonide.
You should only use Desonide if it was prescribed for you and according to your doctor's dosage instructions to minimize adverse effects.
Before using Desonide, you should ensure you are not allergic to any of its ingredients. Do not use Desonide on a child unless prescribed by a doctor. You should also leave the treated area uncovered. If this medication was used in the diaper area, do not use plastic pants or tight-fitting diapers on the baby. Covering the treated area could cause your body to absorb too much of Desonide, which can cause unwanted side effects.
You should also let your doctor know about other medical conditions you may have, including diabetes or other skin problems or a reaction to other steroid medication, and if you are pregnant or breastfeeding.
The most common side effects of Desonide include dry or itchy skin, stinging or burning to the treated area, and acne or stretch marks.
Serious side effects are rare and usually only occur after prolonged use of the drug. Serious side effects may include high blood sugar, cataracts, glaucoma, Cushing syndrome, and adrenal insufficiency.
You should contact your doctor immediately if you have any of these symptoms.
Be aware of possible signs of absorbing the medicine through your skin—weight gain, slow wound healing, thin/discolored skin, increased body hair, muscle weakness, nausea, diarrhea, fatigue, and changes in mood and menstrual cycle.
This is not a complete list of side effects. Consult your doctor or healthcare professional for additional information and medical advice regarding other possible side effects or drug interactions. You can report negative side effects to the FDA.
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