Differin Coupons & Prices

Adapalene

Differin is a topical medication used to treat people with severe acne. It works by increasing your body's turnover of skin cells, which aids in the natural exfoliation of the surface layer of skin. This process of skin cell turnover helps to unclog pores and glands, which can be an important part of skincare. The generic version of Differin is adapalene. The average cost of Differin is $34.91. You can use our SingleCare Differin coupon to pay a lower rate of $34.23 on your next purchase. Read on to learn how to save on Differin, what it is, and how to use it.

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1 pump btl45gm of 0.3%Edit

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Differin coupon at CVS Pharmacy
$37.23
$ 34.23
$3 off with signupwith signup

Show this free card to your pharmacist.

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Differin coupon at Publix Pharmacy
$42.38
$ 39.38
$3 off with signupwith signup

Save an extra $3 on any eligible prescription! Sign up for free

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and it's free to join

Differin coupon at Costco Pharmacy
$ 40.99
Differin coupon at Walgreens Pharmacy
$54.53
$ 51.53
$3 off with signupwith signup
Differin coupon at Walmart Neighborhood Market Pharmacy
$58.32
$ 55.32
$3 off with signupwith signup
Differin coupon at Walmart Pharmacy
$58.32
$ 55.32
$3 off with signupwith signup
$66.80
$ 63.80
$3 off with signupwith signup
$66.80
$ 63.80
$3 off with signupwith signup
$ 74.60

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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About Differin

Differin is a topical medication used to treat people with severe acne. It works by increasing your body's turnover of skin cells, which aids in the natural exfoliation of the surface layer of skin. This process of skin cell turnover helps to unclog pores and glands, which can be an important part of skincare. The generic version of Differin is adapalene. The average cost of Differin is $34.91. You can use our SingleCare Differin coupon to pay a lower rate of $34.23 on your next purchase. Read on to learn how to save on Differin, what it is, and how to use it.

Differin Price History & Information

Price History for Differin (Brand) & Adapalene (Generic)

1 count, tube of gel, 45gm of 0.1%

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Differin (Brand) & Adapalene (Generic)

1 count, tube of gel, 45gm of 0.1%
PharmacyDifferin Retail PriceAdapalene Retail PriceAdapalene SingleCare Price
Walmart-$20.70$20.70
Walgreens$32.85$22.05$22.05
Kroger Pharmacy-$39.50$32.05

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Differin

Differin is a topical medication used to treat people with severe acne. It works by increasing your body's turnover of skin cells, which aids in the natural exfoliation of the surface layer of skin. This process of skin cell turnover helps to unclog pores and glands, which can be an important part of skincare. The generic version of Differin is adapalene. The average cost of Differin is $34.91. You can use our SingleCare Differin coupon to pay a lower rate of $34.23 on your next purchase. Read on to learn how to save on Differin, what it is, and how to use it.

Differin FAQs

How much does Differin cost without insurance?

The average price of Differin without insurance is usually $34.91, but sometimes even more. Registering for a free SingleCare savings card can help you to save on this and other prescriptions. You could pay our lowest price of $34.23 for Differin.

To cut costs even more, you can also ask your pharmacist about adapalene, the generic version of Differin, which may be cheaper than the brand name. SingleCare has coupons for both versions.

How much does Differin cost with insurance?

You may need to check with your health insurance provider or a local pharmacist to find out the price for Differin with insurance, as costs vary among health insurance plans. The price of this medication with a SingleCare discount card is just $34.23, and it's applied to the cash price of the drug.

It's important to ask the pharmacist what the retail price of Differin is because it could be already cheaper than the copay your insurance provides. Compare prices at your local pharmacy to find out how you can save the most on your next Differin refill.

Does Medicare cover Differin and how much does it cost?

Although a small percentage of Medicare plans might partially cover the generic version, Medicare currently does not cover Differin. To save on your next Differin purchase, just use SingleCare's copay card and pay a reduced total of $34.23. Walmart, Kroger, Fry's, Harris Teeter, and Walgreens are just some of the participating pharmacies where you can use your SingleCare card. Search for Differin (or its generic) on our website or app to find the pharmacy near you with the lowest price.

Is there a generic of Differin?

Adapalene is the generic version of Differin. Don't forget that you can redeem SingleCare savings on brand names, generic drugs, and even over-the-counter products.

What is Differin?

Differin is a brand-name medication used to treat acne in people aged 12 years and up. It may help to decrease the severity and number of pimples and promote fast healing of pimples that may develop.

The active ingredient in Differin is adapalene. Adapalene belongs to a class of medications known as retinoids. They work by affecting the growth rate of cells and decreasing inflammation and swelling. Note that this medication is not meant as a treatment for eczema.

This medication may be available as either a prescription drug or an over-the-counter drug.

The acne treatment medication comes in the form of a topical cream and is only meant for use on the skin only. It should not be ingested. Avoid putting this medication on your lips or in your eyes. If this medication gets in your eyes, wash with a large amount of water and call your doctor for medical advice if eye irritation develops. You should not apply Differin to scraped, cut, or sunburnt areas of the skin.

During the first few weeks of using this medication, your acne may appear worse than normal because the medication is interacting with pimples forming inside the skin. You may not see any noticeable changes until eight to 12 weeks of use.

What are the side effects of Differin?

After applying Differin gel, you may experience a brief sensation of warmth or stinging where the medication was applied. Other side effects include but are not limited to redness, itching, dryness, scaling, and mild burning of the skin. These side effects usually decrease after a while as your body becomes adjusted to the medication.

If any of these symptoms persist or worsen, you should contact your doctor or dermatologist promptly. Your doctor may recommend decreasing the strength of your dosage or to stop using it completely. Inquire at your doctor's office or local pharmacy to learn about other side effects that have not been listed here and how to reduce and avoid certain side effects.

Where are Differin coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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