What is Durezol: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 31, 2020

Durezol overview

BRAND NAMES:

  • Durezol

Generic Names:

  • Durezol

Uses:

  • Treats eye irritation and inflammation. This medicine is a corticosteroid.

Therapeutic Classes:

  • Anti-Inflammatory

Forms:

  • Drop, Liquid

How it’s taken:

  • Into the eye

What is Durezol used for?

Durezol is a medication used to treat pain and swelling after eye surgery. Durezol belongs to a class of drugs called corticosteroids (more commonly, “steroids”). This drug is given as eye drops. Durezol is a brand version of the drug difluprednate. This medication has been available for years. In the treatment of post-surgical eye pain, Durezol use is common.

What form(s) does Durezol come in

  • Drop

  • Liquid

What are common Durezol doses?

  • Bottle 5ML of 0.05%

Common Durezol prescriptions

  • Durezol
    5ml of 0.05% bottle

How to take Durezol

  • Ophthalmic routeLie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.

  • Ophthalmic routeTo use the eye drops: Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Keep the bottle upright when you are not using it.

  • Do not touch the eye dropper tip to any surface. This will help keep the medicine free of germs.

  • If you are using this medicine after eye surgery, use a separate bottle for each eye.

  • Missed dose: Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

  • Store the eye drop bottle in the protective carton at room temperature, away from heat, moisture, and direct light. Do not freeze.

  • Ophthalmic routeWash your hands with soap and water before and after using this medicine.

  • Remove contact lenses before you put the drops in your eyes. Wait at least 10 minutes after you use this medicine before you put your contact lenses back in.

  • Use this medicine as directed.

  • Do not touch the eye dropper tip to any surface. This will help keep the medicine free of germs.

  • Store the eye drop bottle in the protective carton at room temperature, away from heat, moisture, and direct light. Do not freeze.

  • Ophthalmic routeTo use the eye drops: Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Keep the bottle upright when you are not using it.

  • Remove contact lenses before you put the drops in your eyes. Wait at least 10 minutes after you use this medicine before you put your contact lenses back in.

  • Missed dose: Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

  • If you are using this medicine after eye surgery, use a separate bottle for each eye.

  • Ophthalmic routeLie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.

  • Use this medicine as directed.

  • Ophthalmic routeWash your hands with soap and water before and after using this medicine.

What to do if you miss a dose of Durezol

Durezol contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to difluprednate.

Durezol warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have glaucoma, cataracts, or an eye infection. Tell your doctor if you had recent eye surgery.

  • This medicine may cause the following problems: Increased pressure in your eye, which can damage the optic nervePosterior subcapsular cataracts (a rare type of cataract)New or worsening eye infectionsSlow or delayed healing after cataract surgery

  • Ophthalmic routeIf you hurt your eye, develop an eye infection, or need to have eye surgery, talk with your doctor right away. You may need to change your medicine or stop using it.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Durezol interactions

  • Tell your doctor if you are pregnant or breastfeeding, or if you have glaucoma, cataracts, or an eye infection. Tell your doctor if you had recent eye surgery.

  • This medicine may cause the following problems: Increased pressure in your eye, which can damage the optic nervePosterior subcapsular cataracts (a rare type of cataract)New or worsening eye infectionsSlow or delayed healing after cataract surgery

  • Ophthalmic routeIf you hurt your eye, develop an eye infection, or need to have eye surgery, talk with your doctor right away. You may need to change your medicine or stop using it.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Durezol side effects

Serious Side Effects

  • Blurred vision, changes in vision

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Increased discharge, redness, or irritation in your eye

  • Eye pain

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