Durezol Coupons & Prices

Difluprednate

Durezol is a prescription medication used to treat inflammation and pain caused by eye surgery or certain eye problems. It works as an ophthalmic corticosteroid that blocks certain substances that cause inflammation. The generic version of Durezol is difluprednate ophthalmic emulsion. The average retail price of Durezol is $278.84 for 1, 5ml of 0.05% bottle. However, with a SingleCare Durezol coupon, you could reduce the retail price to $48.76 for 1, 5ml of 0.05% bottle at participating pharmacies.

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Durezol coupon at CVS Pharmacy
$51.76
$ 48.76
$3 off with signupwith signup

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Durezol coupon at Walmart Neighborhood Market Pharmacy
$61.56
$ 58.56
$3 off with signupwith signup

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Durezol coupon at Walmart Pharmacy
$61.56
$ 58.56
$3 off with signupwith signup
Durezol coupon at Walgreens Pharmacy
$80.90
$ 77.90
$3 off with signupwith signup
Durezol coupon at Kroger Pharmacy
$118.54
$ 115.54
$3 off with signupwith signup
Durezol coupon at Harris Teeter Pharmacy
$118.54
$ 115.54
$3 off with signupwith signup
$ 118.00
$ 119.99
$124.36
$ 121.36
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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About Durezol

Durezol is a prescription medication used to treat inflammation and pain caused by eye surgery or certain eye problems. It works as an ophthalmic corticosteroid that blocks certain substances that cause inflammation. The generic version of Durezol is difluprednate ophthalmic emulsion. The average retail price of Durezol is $278.84 for 1, 5ml of 0.05% bottle. However, with a SingleCare Durezol coupon, you could reduce the retail price to $48.76 for 1, 5ml of 0.05% bottle at participating pharmacies.

Durezol Price History & Information

Price History for Durezol (Brand) & Difluprednate (Generic)

1 count, bottle, 5ml of 0.05%

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Durezol (Brand) & Difluprednate (Generic)

1 count, bottle, 5ml of 0.05%
PharmacyDurezol Retail PriceDifluprednate Retail PriceDifluprednate SingleCare Price
CVS Pharmacy-$200.00$98.75
Walmart$266.85$151.08$49.68
Walgreens$267.00$137.40$83.68
Kroger Pharmacy$267.00$208.62$118.55
Albertsons Pharmacy$276.70$148.70$120.60

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Durezol

Durezol is a prescription medication used to treat inflammation and pain caused by eye surgery or certain eye problems. It works as an ophthalmic corticosteroid that blocks certain substances that cause inflammation. The generic version of Durezol is difluprednate ophthalmic emulsion. The average retail price of Durezol is $278.84 for 1, 5ml of 0.05% bottle. However, with a SingleCare Durezol coupon, you could reduce the retail price to $48.76 for 1, 5ml of 0.05% bottle at participating pharmacies.

Durezol FAQs

Medically reviewed by Gerardo SisonPharm.D.
Licensed Pharmacist

How much does Durezol cost without insurance?

Without insurance, the average cost of Durezol is $278.84 for 1, 5ml of 0.05% bottle. Prices can fluctuate based on the pharmacy location and the quantity prescribed. You may want to compare prices at local pharmacies. SingleCare offers a Durezol coupon that may help you save, bringing the cost down to $48.76 for 1, 5ml of 0.05% bottle at participating pharmacies.

How much does Durezol cost with insurance?

Insurance coverage for Durezol can vary depending on your plan and the prescribed quantity. In many cases, you may be responsible for a copay or coinsurance amount, which may affect the final out-of-pocket cost. Contact your health insurance provider or pharmacist to determine the total cost of Durezol with insurance. You may be able to save more money with a SingleCare Durezol coupon than with your insurance plan. 

Does Medicare cover Durezol and how much does it cost?

Coverage for Durezol under Medicare will vary by plan and prescription quantity. Check with your plan’s provider or pharmacist to determine the cost of Durezol with Medicare. If you lack adequate Medicare coverage, a SingleCare Durezol coupon could help you get the lowest prices. In some cases, using the SingleCare card could save you more than using Medicare.

How to save on Durezol

There are currently no manufacturer coupons for Durezol. However, individuals facing financial hardship may find patient assistance programs offered by non-profits or national-level programs. For example, the Patient Access Network Foundation (PAN) is a third-party organization that may offer financial assistance for Durezol. Patient assistance programs may often provide prescription medications at a reduced cost or free of charge to eligible patients.

Another potential way to save on Durezol is through SingleCare. SingleCare offers a prescription discount card that may reduce the cost of numerous prescription medications. With a SingleCare Durezol coupon, you may be able to obtain the medicine for $48.76 for 1, 5ml of 0.05% bottle. To access a discounted price, simply present the SingleCare card at a participating pharmacy.

Is there a generic of Durezol?

A generic equivalent is currently available for Durezol in the United States. The generic version of Durezol is difluprednate emulsion. 

What is Durezol?

Durezol is an eye medication used to treat inflammation and pain associated with eye surgery and certain eye problems. It may be prescribed after cataract surgery to help the eye heal and reduce discomfort. Durezol contains the active ingredient difluprednate and works by altering the body's immune response to reduce inflammation and pain in the eye.

What doses of Durezol are available?

Durezol is available as a 0.05% difluprednate ophthalmic emulsion. The prescribed dosage will depend on the medical condition being treated. For pain and inflammation after eye surgery, the medication is usually instilled into the affected eye four times daily for the first two weeks. The medication is then reduced to twice daily for one week and further reduced over time. Durezol is instilled into the affected eye four times daily for two weeks to treat endogenous anterior uveitis, with the dosage being gradually reduced over time. Contact a healthcare provider for the appropriate way to administer Durezol.

What are the side effects of Durezol?

Durezol may cause side effects that can range from mild to severe. In many cases, side effects are mild and temporary. Common side effects of {{drug} include:

  • Eye pain

  • Blurred vision

  • Dry or itchy eyes

  • Sensitivity to light

The use of steroids in the eyes may be linked to serious adverse effects such as infections, cataracts, and glaucoma. Consult a healthcare provider for medical advice and additional information on other potential precautions or warnings.

Can Durezol be used long term?

Durezol eye drops are not typically recommended for long-term use. The long-term use of Durezol and other ophthalmic corticosteroids should be monitored by a healthcare provider. Long-term use may increase the risk of complications like optic nerve damage, vision problems, and infections. Consult your healthcare provider if you have any questions or concerns about using Durezol. 

Is there a shortage of Durezol?

There is currently no known shortage of Durezol from Novartis Pharmaceuticals, the primary manufacturer of Durezol. However, availability may vary by location and pharmacy. You may want to call your local pharmacy for the most accurate and up-to-date information. You can also check the FDA drug shortage database for additional information. Generic versions of Durezol may be more available and accessible than the brand-name version.

Medically reviewed by Gerardo SisonPharm.D.
Licensed Pharmacist

Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.

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Where are Durezol coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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