Epiduo is a brand-name acne prescription gel that contains adapalene and benzoyl peroxide to renew skin, which is applicable to patients above the age of nine years old. This combination of drugs aids in new skin cell growth and helps eliminate bacteria that may cause acne. The retail price of Epiduo costs $524.93 for 1, 45gm of 0.1-2.5% pump btl of Epiduo without insurance or discounts. Fortunately, you can save on drug pricing and pay a discounted price of $31.89 for 1, 45gm of 0.1-2.5% pump btl of generic Epiduo by using Epiduo coupons at participating pharmacies, including CVS Pharmacy, Walmart Pharmacy, and Walgreens.
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About SingleCare Pricing
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/18/2025
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About Epiduo
Epiduo is a brand-name acne prescription gel that contains adapalene and benzoyl peroxide to renew skin, which is applicable to patients above the age of nine years old. This combination of drugs aids in new skin cell growth and helps eliminate bacteria that may cause acne. The retail price of Epiduo costs $524.93 for 1, 45gm of 0.1-2.5% pump btl of Epiduo without insurance or discounts. Fortunately, you can save on drug pricing and pay a discounted price of $31.89 for 1, 45gm of 0.1-2.5% pump btl of generic Epiduo by using Epiduo coupons at participating pharmacies, including CVS Pharmacy, Walmart Pharmacy, and Walgreens.
Price History for Epiduo (Brand) & Adapalene-Benzoyl Peroxide (Generic)
1 count, pump btl, 45gm of 0.1-2.5%
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
Average 1-Month Prices for Epiduo (Brand) & Adapalene-Benzoyl Peroxide (Generic)
1 count, pump btl, 45gm of 0.1-2.5%
Pharmacy
Adapalene-Benzoyl Peroxide Retail Price
Adapalene-Benzoyl Peroxide SingleCare Price
CVS Pharmacy
$297.00
$149.85
Walmart
$412.20
$30.15
Walgreens
$300.15
$52.65
Kroger Pharmacy
$418.39
$51.30
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
About Epiduo
Epiduo is a brand-name acne prescription gel that contains adapalene and benzoyl peroxide to renew skin, which is applicable to patients above the age of nine years old. This combination of drugs aids in new skin cell growth and helps eliminate bacteria that may cause acne. The retail price of Epiduo costs $524.93 for 1, 45gm of 0.1-2.5% pump btl of Epiduo without insurance or discounts. Fortunately, you can save on drug pricing and pay a discounted price of $31.89 for 1, 45gm of 0.1-2.5% pump btl of generic Epiduo by using Epiduo coupons at participating pharmacies, including CVS Pharmacy, Walmart Pharmacy, and Walgreens.
Epiduo typically costs $524.93 for 1, 45gm of 0.1-2.5% pump btl of Epiduo but you have a greater chance of saving more when you use Epiduo drug coupons from SingleCare. SingleCare card users can save up to 80% on their prescription medications.
How much does Epiduo cost with insurance?
Epiduo costs an average of $524.93 for 1, 45gm of 0.1-2.5% pump btl of Epiduo but your copay can vary by insurance plan. Talk with a pharmacist near you to find out your copay with insurance. With SingleCare, the price of Epiduo can be as low as $31.89 for 1, 45gm of 0.1-2.5% pump btl of generic Epiduo. This can be even cheaper than some insurance plans.
Does Medicare cover Epiduo and how much does it cost?
Although Epiduo is not commonly covered by Medicare, you can contact your Medicare health insurance provider to find out if your particular plan covers Epiduo. Depending on your Medicare plan, you can pay between $0 and $244 for Epiduo.
SingleCare provides a free and easy way to save you even more money. Using a SingleCare savings card can save you up to 80% on your prescription drug prices. Visit a local participating pharmacy, like CVS Pharmacy, Walmart, Kroger, or Walgreens, to apply your SingleCare prescription discount card to ensure you're paying the lowest price.
Is there a generic of Epiduo?
Epiduo is the brand-name prescription drug. Adapalene-benzoyl peroxide topical is the generic version of Epiduo, which is applicable to patients above the age of nine years old. Use our Epiduo coupons above and pay as low as $31.89 for 1, 45gm of 0.1-2.5% pump btl of generic Epiduo on your next refill on the brand name or search singlecare.com to find out how much you can save on the generic version.
What is Epiduo?
Epiduo is an FDA-approved prescription topical gel used to treat acne. It contains adapalene and benzoyl peroxide to help the skin to renew itself. Adapalene is similar to vitamin A and helps to repair the skin while benzoyl-peroxide acts as an antibacterial agent.
What doses of Epiduo are available?
Epiduo is in the form of a gel and is supplied in a 45 g tube. A pea-sized amount is to be applied as a thin layer to the affected areas once daily (after washing) for best results. It is recommended that you follow your doctor's instructions when using Epiduo.
What are the side effects of Epiduo?
You should let your healthcare provider know if you are using any other acne medication, as a combination of Epiduo and other drugs may result in severe skin irritation. Other side effects include dry skin, contact dermatitis, skin irritation, eczema, and local reactions including erythema, scaling, dryness, burning, and stinging. Other side effects may occur. Call your doctor if you experience one or more of these side effects or need additional information on the adverse effects of Epiduo.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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Where are Epiduo coupons from SingleCare accepted?
SingleCare is accepted at most national pharmacies and grocers, including the following:
