Epiduo is a brand-name acne prescription gel that contains adapalene and benzoyl peroxide to renew skin, which is applicable to patients above the age of nine years old. This combination of drugs aids in new skin cell growth and helps eliminate bacteria that may cause acne. The retail price of Epiduo costs $525.17 for 1, 45gm of 0.1-2.5% pump btl of Epiduo without insurance or discounts. Fortunately, you can save on drug pricing and pay a discounted price of $31.45 for 1, 45gm of 0.1-2.5% pump btl of generic Epiduo by using Epiduo coupons at participating pharmacies, including CVS Pharmacy, Walmart Pharmacy, and Walgreens.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 05/05/2026
Epiduo is a brand-name acne prescription gel that contains adapalene and benzoyl peroxide to renew skin, which is applicable to patients above the age of nine years old. This combination of drugs aids in new skin cell growth and helps eliminate bacteria that may cause acne. The retail price of Epiduo costs $525.17 for 1, 45gm of 0.1-2.5% pump btl of Epiduo without insurance or discounts. Fortunately, you can save on drug pricing and pay a discounted price of $31.45 for 1, 45gm of 0.1-2.5% pump btl of generic Epiduo by using Epiduo coupons at participating pharmacies, including CVS Pharmacy, Walmart Pharmacy, and Walgreens.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Epiduo Retail Price | Adapalene-Benzoyl Peroxide Retail Price | Adapalene-Benzoyl Peroxide SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $513.90 | $297.00 | $28.96 |
| Walmart | - | $429.30 | $51.30 |
| Walgreens | - | $300.15 | $97.10 |
| Kroger Pharmacy | - | $390.86 | $51.30 |
| Albertsons Pharmacy | - | $378.90 | $47.70 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Epiduo is a brand-name acne prescription gel that contains adapalene and benzoyl peroxide to renew skin, which is applicable to patients above the age of nine years old. This combination of drugs aids in new skin cell growth and helps eliminate bacteria that may cause acne. The retail price of Epiduo costs $525.17 for 1, 45gm of 0.1-2.5% pump btl of Epiduo without insurance or discounts. Fortunately, you can save on drug pricing and pay a discounted price of $31.45 for 1, 45gm of 0.1-2.5% pump btl of generic Epiduo by using Epiduo coupons at participating pharmacies, including CVS Pharmacy, Walmart Pharmacy, and Walgreens.
Epiduo typically costs $525.17 for 1, 45gm of 0.1-2.5% pump btl of Epiduo but you have a greater chance of saving more when you use Epiduo drug coupons from SingleCare. SingleCare card users can save up to 80% on their prescription medications.
Epiduo costs an average of $525.17 for 1, 45gm of 0.1-2.5% pump btl of Epiduo but your copay can vary by insurance plan. Talk with a pharmacist near you to find out your copay with insurance. With SingleCare, the price of Epiduo can be as low as $31.45 for 1, 45gm of 0.1-2.5% pump btl of generic Epiduo. This can be even cheaper than some insurance plans.
Although Epiduo is not commonly covered by Medicare, you can contact your Medicare health insurance provider to find out if your particular plan covers Epiduo. Depending on your Medicare plan, you can pay between $0 and $244 for Epiduo.
SingleCare provides a free and easy way to save you even more money. Using a SingleCare savings card can save you up to 80% on your prescription drug prices. Visit a local participating pharmacy, like CVS Pharmacy, Walmart, Kroger, or Walgreens, to apply your SingleCare prescription discount card to ensure you're paying the lowest price.
Epiduo is the brand-name prescription drug. Adapalene-benzoyl peroxide topical is the generic version of Epiduo, which is applicable to patients above the age of nine years old. Use our Epiduo coupons above and pay as low as $31.45 for 1, 45gm of 0.1-2.5% pump btl of generic Epiduo on your next refill on the brand name or search singlecare.com to find out how much you can save on the generic version.
Epiduo is an FDA-approved prescription topical gel used to treat acne. It contains adapalene and benzoyl peroxide to help the skin to renew itself. Adapalene is similar to vitamin A and helps to repair the skin while benzoyl-peroxide acts as an antibacterial agent.
Epiduo is in the form of a gel and is supplied in a 45 g tube. A pea-sized amount is to be applied as a thin layer to the affected areas once daily (after washing) for best results. It is recommended that you follow your doctor's instructions when using Epiduo.
You should let your healthcare provider know if you are using any other acne medication, as a combination of Epiduo and other drugs may result in severe skin irritation. Other side effects include dry skin, contact dermatitis, skin irritation, eczema, and local reactions including erythema, scaling, dryness, burning, and stinging. Other side effects may occur. Call your doctor if you experience one or more of these side effects or need additional information on the adverse effects of Epiduo.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved