Sulfamethoxazole-Trimethoprim is a combination antibiotic used to treat various bacterial infections, including urinary tract infections, ear infections, respiratory tract infections, and intestinal infections. Sulfamethoxazole-Trimethoprim combines a sulfonamide or sulfa drug (sulfamethoxazole) with an antifolate agent (trimethoprim). Sulfamethoxazole-Trimethoprim is a generic drug known under the brand name Bactrim. On average, the retail price of Sulfamethoxazole-Trimethoprim is $22.16 for 14, 800-160mg tablets. However, with a SingleCare savings card, the retail cost of Sulfamethoxazole-Trimethoprim may be reduced to $2.80 for 14, 800-160mg tablets at participating pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Sulfamethoxazole-Trimethoprim is a combination antibiotic used to treat various bacterial infections, including urinary tract infections, ear infections, respiratory tract infections, and intestinal infections. Sulfamethoxazole-Trimethoprim combines a sulfonamide or sulfa drug (sulfamethoxazole) with an antifolate agent (trimethoprim). Sulfamethoxazole-Trimethoprim is a generic drug known under the brand name Bactrim. On average, the retail price of Sulfamethoxazole-Trimethoprim is $22.16 for 14, 800-160mg tablets. However, with a SingleCare savings card, the retail cost of Sulfamethoxazole-Trimethoprim may be reduced to $2.80 for 14, 800-160mg tablets at participating pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Sulfamethoxazole-Trimethoprim Retail Price | Sulfamethoxazole-Trimethoprim SingleCare Price |
|---|---|---|
| CVS Pharmacy | $22.36 | $14.95 |
| Walmart | $7.96 | $7.84 |
| Walgreens | $17.25 | $11.86 |
| Kroger Pharmacy | $10.76 | $5.74 |
| Albertsons Pharmacy | $21.98 | $11.48 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Sulfamethoxazole-Trimethoprim is a combination antibiotic used to treat various bacterial infections, including urinary tract infections, ear infections, respiratory tract infections, and intestinal infections. Sulfamethoxazole-Trimethoprim combines a sulfonamide or sulfa drug (sulfamethoxazole) with an antifolate agent (trimethoprim). Sulfamethoxazole-Trimethoprim is a generic drug known under the brand name Bactrim. On average, the retail price of Sulfamethoxazole-Trimethoprim is $22.16 for 14, 800-160mg tablets. However, with a SingleCare savings card, the retail cost of Sulfamethoxazole-Trimethoprim may be reduced to $2.80 for 14, 800-160mg tablets at participating pharmacies.
The average retail cost of Sulfamethoxazole-Trimethoprim is $22.16 for 14, 800-160mg tablets. However, the price can vary depending on the dosage and quantity prescribed, among other factors. You may want to compare prescription prices without insurance at local pharmacies. With a SingleCare card or coupon, you may be able to pay a reduced retail price at participating pharmacies.
Copay and coinsurance amounts for Sulfamethoxazole-Trimethoprim will depend on your insurance plan. The cost of Sulfamethoxazole-Trimethoprim may also depend on the quantity, dosage form, and strength prescribed. Check with your insurance plan’s formulary or contact your insurance company directly to determine your cost with insurance coverage. You can also contact your pharmacist who can calculate your out-of-pocket costs with insurance.
Sulfamethoxazole-Trimethoprim is typically covered by Medicare Part D and Medicare Advantage prescription drug plans. You may be responsible for a copay or coinsurance amount. If you’ve not met your deductible, you may have to pay the full cash price of your prescription medication. If you are not covered by Medicare, a SingleCare Sulfamethoxazole-Trimethoprim coupon could lower the retail cost of Sulfamethoxazole-Trimethoprim.
Brand names of Sulfamethoxazole-Trimethoprim include Bactrim and Septra. Sulfamethoxazole-Trimethoprim is a generic drug produced by various pharmaceutical manufacturers such as Amneal Pharmaceuticals and Aurobindo Pharma.
Sulfamethoxazole-Trimethoprim is a combination antibiotic used to treat certain bacterial infections, including urinary tract infections, middle ear infections, E. coli infections (traveler's diarrhea), bronchitis, pneumocystis pneumonia, and intestinal infections caused by Shigella bacteria (shigellosis). It may also be used to prevent bacterial infections, especially in people with HIV who are immunodeficient.
Sulfamethoxazole belongs to a class of broad-spectrum antibiotics called sulfa drugs that prevent bacteria from making dihydrofolic acid. Trimethoprim is an antifolate agent that prevents bacteria from making tetrahydrofolic acid. By interrupting the production of folic acid, Sulfamethoxazole-Trimethoprim stops DNA and protein production necessary for bacterial growth.
Sulfamethoxazole-Trimethoprim is usually taken orally as a tablet or oral suspension. It is available in regular-strength tablets that contain 400 mg of sulfamethoxazole and 80 mg of trimethoprim. It is also available as a double-strength tablet containing 800 mg of sulfamethoxazole and 160 mg of trimethoprim. For patients who are unable to take Sulfamethoxazole-Trimethoprim orally, it can be administered as an injection.
Sulfamethoxazole-Trimethoprim is not used to treat fungal or viral infections.
The most common side effects of Sulfamethoxazole-Trimethoprim are nausea, vomiting, and loss of appetite. Allergic skin reactions are also common and include hives and rashes.
Sulfamethoxazole-Trimethoprim can cause severe but rare side effects: anemia (low red blood cell counts), hepatitis (inflammation of the liver), and severe allergic reactions, which include severe skin reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome. Seek medical help immediately if you experience symptoms or signs of an allergic reaction, such as rash, swelling of the throat or face, and trouble breathing.
This is not a complete list of potential side effects that may occur. Consult your doctor or healthcare professional for additional information and medical advice regarding other possible side effects or drug interactions.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved