Epifoam (hydrocortisone acetate and pramoxine) is a prescription topical combination drug that treats the symptoms of various mild to moderate skin or anal conditions. The active ingredients in Epifoam reduce swelling (hydrocortisone acetate) and temporarily numb the area (pramoxine). Epifoam does not actually treat the underlying cause of the skin condition. The pharmacy price of Epifoam is $138.48, but with SingleCare's Epifoam coupon, it costs only $104.82. Find out more about Epifoam in our FAQs below: what it is, how it works, how much it costs, and how to save money on your prescription.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 05/07/2026
Epifoam (hydrocortisone acetate and pramoxine) is a prescription topical combination drug that treats the symptoms of various mild to moderate skin or anal conditions. The active ingredients in Epifoam reduce swelling (hydrocortisone acetate) and temporarily numb the area (pramoxine). Epifoam does not actually treat the underlying cause of the skin condition. The pharmacy price of Epifoam is $138.48, but with SingleCare's Epifoam coupon, it costs only $104.82. Find out more about Epifoam in our FAQs below: what it is, how it works, how much it costs, and how to save money on your prescription.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Epifoam Retail Price | Epifoam SingleCare Price |
|---|---|---|
| Walmart | $126.20 | $115.90 |
| Walgreens | $129.00 | $116.90 |
| Kroger Pharmacy | $127.00 | $107.80 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Epifoam (hydrocortisone acetate and pramoxine) is a prescription topical combination drug that treats the symptoms of various mild to moderate skin or anal conditions. The active ingredients in Epifoam reduce swelling (hydrocortisone acetate) and temporarily numb the area (pramoxine). Epifoam does not actually treat the underlying cause of the skin condition. The pharmacy price of Epifoam is $138.48, but with SingleCare's Epifoam coupon, it costs only $104.82. Find out more about Epifoam in our FAQs below: what it is, how it works, how much it costs, and how to save money on your prescription.
Uninsured customers will pay $138.48, but Epifoam prices can vary. Visit any participating pharmacy and pay only $104.82 with a SingleCare Epifoam coupon. Your SingleCare discount card can reduce your prescription drug prices by up to 80%.
Your copay for Epifoam with insurance will vary. Ask your pharmacist to compare your insurance copay to SingleCare. You may find a SingleCare discount card saves you more money than insurance—with SingleCare, Epifoam costs only $104.82 for 1, 10gm of 1-1% can.
Epifoam is usually not covered by Medicare Advantage and Medicare Part D prescription drug plans. Patients with Medicare can rely on a SingleCare Epifoam coupon for significant savings on Epifoam at major pharmacies around the country, such as CVS, Target, Walmart, and many others.
Epifoam is a brand-name prescription topical drug. Other generic versions are available as hydrocortisone-pramoxine topicals from suppliers such as Sebela, Acella, and Ferndale, which markets its generic as Pramosone. Search for Epifoam, Pramosone, or generic hydrocortisone-pramoxine on our website or app for more information and savings coupons.
Epifoam (pramoxine and hydrocortisone acetate) is a brand-name prescription topical drug that relieves the swelling, itchiness, and discomfort of various mild to moderate skin and anal conditions. Epifoam, however, does not treat the underlying condition.
Hydrocortisone acetate is an artificial steroid that belongs to a class of drugs called corticosteroids, which activate chemicals in the body that reduce swelling. When absorbed into the skin, Epifoam reduces the swelling that causes skin irritation, itching, and redness.
Pramoxine is a mild anesthetic that relieves itching, discomfort, and minor pain by temporarily numbing the area of the skin it is applied to. It is frequently prescribed as a stand-alone topical for cuts, bug bites, poison ivy, and other minor to moderate skin conditions.
Epifoam is available as an aerosol foam, cream, ointment, or lotion.
The most common side effects of Epifoam are irritation, stinging, burning, rash, hives, and other site reactions. Hydrocortisone acetate may cause skin spots, skin thinning, stretch marks, or acne. Hydrocortisone acetate is absorbed into the body and long-term use may cause high blood sugar, cataracts, and glaucoma.
The most common side effects of pramoxine are site reactions, such as redness, swelling, burning, or stinging. Other side effects include dry skin and bleeding. Allergic reactions could be severe and include hives, severe itching, difficulty breathing, and swelling.
This is not a complete list of side effects and others may occur. If you have questions about side effects, consult with your doctor or pharmacist.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved