What is Ferriprox: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Ferriprox overview

BRAND NAMES:

  • Chemet, Clovique, Cuprimine, Depen, Ferriprox, Ferriprox Twice-A-Day, Syprine, Jadenu, Ferriprox Twice-A-Day, Ferriprox

Generic Names:

  • Ferriprox

Uses:

  • Treats heavy metal poisoning. May also be used to treat rheumatoid arthritis or cystinuria (too much cystine in your urine)., Treats iron toxicity (too much iron in the blood). This medicine is an iron chelator (binder).

Therapeutic Classes:

  • Heavy Metal Chelator, Antirheumatic, Heavy Metal Chelator, Renal-Urologic Agent

Forms:

  • Tablet, Capsule, Tablet, Liquid

How it’s taken:

  • By mouth, By mouth

What is Ferriprox used for?

Ferriprox is prescribed to patients diagnosed with thalassemia syndrome who have an excessive amount of iron in their body caused by a blood transfusion. Thalassemia syndrome is an inherited blood disease that causes a deficiency in hemoglobin. Ferriprox removes the excessive iron content within the bloodstream to prevent damage to organs.

What form(s) does Ferriprox come in

  • Tablet

  • Capsule

  • Tablet

  • Liquid

What are common Ferriprox doses?

  • Tablet 500MG

Common Ferriprox prescriptions

  • Ferriprox
    500ml of 100mg/ml bottle

How to take Ferriprox

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Oral liquid: You may store the medicine at room temperature for up to 8 weeks. Throw away any unused medicine after 8 weeks.Tablets: Keep the bottle tightly closed. Use the medicine dispensed only in its original container.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Take the first dose of this medicine in the morning, the second dose at mid-day, and the third dose in the evening with meals, unless your doctor tells you otherwise.

  • Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take the first dose of this medicine in the morning, the second dose at mid-day, and the third dose in the evening with meals, unless your doctor tells you otherwise.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Oral liquid: You may store the medicine at room temperature for up to 8 weeks. Throw away any unused medicine after 8 weeks.Tablets: Keep the bottle tightly closed. Use the medicine dispensed only in its original container.

  • You might need to take this medicine on an empty stomach. Take penicillamine or trientine at least 1 hour before eating a meal or 2 hours after eating a meal. Do not eat or drink milk within 1 hour of the time you take this medicine. Ask your doctor or pharmacist if you have questions about what schedule to follow.

  • Oral routeCarefully follow your doctor's instructions about any special diet.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Do not open or chew trientine capsule. If you get any of this medicine on your skin, wash it off right away.

  • If you cannot swallow the succimer capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing. You can also pour the medicine beads into a spoon, swallow the beads, and then drink some fruit drink.

  • You might need to drink extra water while you are using this medicine.

  • Oral routeCarefully follow your doctor's instructions about any special diet.

  • Do not open or chew trientine capsule. If you get any of this medicine on your skin, wash it off right away.

  • If you cannot swallow the succimer capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing. You can also pour the medicine beads into a spoon, swallow the beads, and then drink some fruit drink.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • You might need to take this medicine on an empty stomach. Take penicillamine or trientine at least 1 hour before eating a meal or 2 hours after eating a meal. Do not eat or drink milk within 1 hour of the time you take this medicine. Ask your doctor or pharmacist if you have questions about what schedule to follow.

  • You might need to drink extra water while you are using this medicine.

What to do if you miss a dose of Ferriprox

  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Ferriprox contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to deferiprone, or if you are pregnant.

  • Make sure your doctor knows if you have had an allergic reaction to any chelating agent such as penicillamine, succimer, or trientine. Make sure your doctor knows if you are pregnant or breastfeeding. Tell your doctor if you have kidney disease.

Ferriprox warnings

  • Your skin might be more fragile while you are using penicillamine, especially on your shoulders, elbows, knees, toes, or buttocks. Your skin might also heal more slowly than usual. Talk to your doctor before you have any kind of surgery, because your dose of this medicine might need to be changed.

  • You might need to take your temperature every night when you first start using this medicine.

  • For people who have diabetes: Succimer may affect the results of some urine tests for ketones (such as Ketostix®). Ask your doctor what kind of ketone test you should use while you are using succimer.

  • For Wilson€™s disease, you might need to use this medicine for one to three months before you notice any improvement. The symptoms of Wilson€™s disease might get worse when you first start using this medicine. If your symptoms get very bad or keep getting worse, tell your doctor.

  • Some people have too much heavy metal in their bodies because they were exposed to it, such as in the home or at work. The metal could still be in their surroundings. If this is your situation, then you must get rid of the metal or learn how to protect yourself. This medicine will not protect you from a heavy metal that you are still being exposed to. Find out how you were exposed. Ask your health caregiver about the best ways to get rid of or avoid the heavy metal that caused the problem.

  • Tell your doctor if you have ever used a chelating agent before.

  • Make sure any doctor or dentist who treats you knows that you are using this medicine.

  • Do not stop using this medicine without talking to your doctor first.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or problems with your blood. Tell your doctor if you are allergic to penicillin.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine may cause your urine to turn red or brownish. This is normal and nothing to worry about.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use an effective form of birth control during treatment with this medicine and for at least 6 months after the last dose. Male patients with female partners who can become pregnant must use an effective form of birth control during treatment and for at least 3 months after the last dose.

  • Do not breastfeed during treatment and for at least 2 weeks after the last dose.

  • Tell your doctor if you have liver disease, blood or bone marrow problems, or any type of infection.

  • This medicine lowers the number of white blood cells. This weakens your immune system, so you may get infections more easily. Wash your hands often. Avoid people who are sick.

Ferriprox interactions

  • Some foods and medicines can affect how deferiprone works. Tell your doctor if you are using diclofenac, probenecid, or silymarin (milk thistle).

  • Do not take anything that contains aluminum, iron, or zinc within 4 hours before or after you take deferiprone. This includes antacids, multivitamins, and supplements.

  • This medicine lowers the number of white blood cells. This weakens your immune system, so you may get infections more easily. Wash your hands often. Avoid people who are sick.

  • This medicine may cause your urine to turn red or brownish. This is normal.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • You might need to take your temperature every night when you first start using this medicine.

  • Your skin might be more fragile while you are using penicillamine, especially on your shoulders, elbows, knees, toes, or buttocks. Your skin might also heal more slowly than usual. Talk to your doctor before you have any kind of surgery, because your dose of this medicine might need to be changed.

  • For people who have diabetes: Succimer may affect the results of some urine tests for ketones (such as Ketostix®). Ask your doctor what kind of ketone test you should use while you are using succimer.

  • For Wilson€™s disease, you might need to use this medicine for one to three months before you notice any improvement. The symptoms of Wilson€™s disease might get worse when you first start using this medicine. If your symptoms get very bad or keep getting worse, tell your doctor.

  • Some people have too much heavy metal in their bodies because they were exposed to it, such as in the home or at work. The metal could still be in their surroundings. If this is your situation, then you must get rid of the metal or learn how to protect yourself. This medicine will not protect you from a heavy metal that you are still being exposed to. Find out how you were exposed. Ask your health caregiver about the best ways to get rid of or avoid the heavy metal that caused the problem.

  • Tell your doctor if you are also using any vitamin, mineral, or iron supplements.

  • Do not take any other medicine at the same time you take penicillamine. Always allow at least 1 hour between the time you take penicillamine and the time you take other medicines. If you are using a different chelating medicine, ask your doctor.

  • Make sure your doctor knows if you are also using phenylbutazone or medicine to treat malaria, such as mefloquine, quinine, quinidine, chloroquine, atovaquone/proguanil, Lariam®, Malarone®, Aralen®.

  • Tell your doctor if you have ever used a chelating agent before.

  • Make sure your doctor knows if you are also using any other medicines to lower the amount of metal in your body.

Ferriprox side effects

Serious Side Effects

  • Fever, chills, cough, sore throat, body aches

  • Lightheadedness, dizziness, fainting

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Fast, pounding, or uneven heartbeat

  • Skin rash, itching, redness (at any time during treatment, or after treatment stops).

  • Unusual bleeding, bruising, or weakness.

  • Seizures, clumsiness.

  • Scaly, red, or flaky patches on your skin, or skin blisters (especially in your mouth).

  • Muscle weakness, drooping eyelids, double vision, trouble seeing.

  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Bloody or cloudy urine.

  • Fever, by itself or with chills or sore throat.

  • Trouble breathing, coughing up blood, unexplained cough or wheezing.

Less Serious Side Effects

  • Nausea, vomiting, diarrhea, stomach pain, loss of appetite or ability to taste.

  • Sores, swelling, cracks, or white patches on your lips, mouth, or throat.

  • Metallic taste in your mouth.

  • Skin wrinkles, small white spots.

  • Ringing in your ears.

  • Unusual muscle pain, or joint pain or swelling.

  • Dizziness, sleepiness.

  • Red or brown urine

  • Red or brown urine

  • Muscle or joint pain