What is Glucotrol XL: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Glucotrol XL overview

BRAND NAMES:

  • Glucotrol, Glucotrol XL

Generic Names:

  • Glipizide Er

Uses:

  • Treats type 2 diabetes.

Therapeutic Classes:

  • Hypoglycemic

Forms:

  • Tablet, Long Acting Tablet

How it’s taken:

  • By mouth

What is Glucotrol XL used for?

What form(s) does Glucotrol XL come in

  • Tablet

  • Long Acting Tablet

What are common Glucotrol XL doses?

  • Tablet 2.5mg

  • Tablet 5mg

  • Tablet 10mg

Common Glucotrol XL prescriptions

  • Glucotrol XL
    10mg tablet

  • Glucotrol XL
    2.5mg tablet

  • Glucotrol XL
    5mg tablet

  • Glucotrol XL
    5mg tablet extended release 24 hour

How to take Glucotrol XL

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Take the regular tablet about 30 minutes before you eat a meal. Take the extended-release tablet with breakfast, unless your doctor tells you differently.

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Take the regular tablet about 30 minutes before you eat a meal. Take the extended-release tablet with breakfast, unless your doctor tells you differently.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

What to do if you miss a dose of Glucotrol XL

Glucotrol XL contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to glipizide.

Glucotrol XL warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel problems, stomach or bowel problems, adrenal or pituitary gland problems, or G6PD deficiency. Tell your doctor if you drink alcohol.

  • This medicine may cause the following problems:Higher risk of heart or blood vessel problemsLow blood sugar

  • Part of the extended-release tablet may pass in your stool. This is normal.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Glucotrol XL interactions

  • Some medicines can affect how glipizide works. Tell your doctor if you are using any of the following:Aspirin, chloramphenicol, fluconazole, isoniazid, miconazole, niacin, phenytoin, probenecidBirth control pillBeta blocker medicineBlood thinner (including warfarin)Diuretic (water pill)MAO inhibitorMedicine to treat an infection (including ciprofloxacin, levofloxacin, moxifloxacin)NSAID pain or arthritis medicine (including celecoxib, diclofenac, ibuprofen, naproxen)Phenothiazine medicineSteroid medicineSulfa drugThyroid medicine

  • If you are also taking colesevelam, take it at least 4 hours after you take glipizide.

  • Part of the extended-release tablet may pass in your stool. This is normal.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Glucotrol XL side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Fast or pounding heartbeat, lightheadedness, dizziness

  • Blurred vision, changes in vision

  • Headache or confusion

  • Sweating, trembling, shakiness, increased hunger

Less Serious Side Effects

  • Mild nausea, diarrhea, stomach upset

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