What is Imipenem-Cilastatin: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Imipenem-Cilastatin overview

BRAND NAMES:

  • Imipenem and Cilastatin Novaplus, PremierPro Rx Imipenem and Cilastatin, Primaxin IV

Generic Names:

  • Imipenem-Cilastatin

Uses:

  • Treats infections.

Therapeutic Classes:

  • Antibiotic

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Imipenem-Cilastatin used for?

What form(s) does Imipenem-Cilastatin come in

  • Injectable

What are common Imipenem-Cilastatin doses?

  • Solution Reconstituted 250MG

  • Solution Reconstituted 500MG

Common Imipenem-Cilastatin prescriptions

  • Imipenem-Cilastatin
    250mg solution reconstituted

  • Imipenem-Cilastatin
    500mg solution reconstituted

How to take Imipenem-Cilastatin

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Missed dose: You should receive your medicine as soon as possible, unless it is almost time for your next dose. Ask your caregiver if you have questions.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Missed dose: You should receive your medicine as soon as possible, unless it is almost time for your next dose. Ask your caregiver if you have questions.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

What to do if you miss a dose of Imipenem-Cilastatin

Imipenem-Cilastatin contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to imipenem or cilastatin. Tell your doctor if you are allergic to any other antibiotic, especially a penicillin or cephalosporin.

Imipenem-Cilastatin warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, seizures or similar nervous system conditions, or allergies.

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Seizures, confusion, tremors

Imipenem-Cilastatin interactions

  • Some medicines and foods can affect how this drug works. Tell your doctor if you are also using any of the following: GanciclovirSeizure medicine, including divalproex sodium or valproic acid Probenecid

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Call your doctor if your symptoms do not improve or if they get worse.

Imipenem-Cilastatin side effects

Serious Side Effects

  • Blistering, peeling red skin rash

  • Severe diarrhea, which may contain blood

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Seizures, confusion, tremors

Less Serious Side Effects

  • Mild diarrhea, nausea, or vomiting