What is Imipramine Pamoate: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Imipramine Pamoate overview

BRAND NAMES:

  • Tofranil

Generic Names:

  • Imipramine Pamoate

Uses:

  • Treats depression. Also used to treat bedwetting in children. This medicine is a TCA.

Therapeutic Classes:

  • Antidepressant, Urinary Enuresis Agent

Forms:

  • Capsule, Tablet

How it’s taken:

  • By mouth

What is Imipramine Pamoate used for?

Imipramine Pamoate is a tricyclic antidepressant used to treat depression. It works by changing the unstable chemicals in the brain causing depression. Also, It is sometimes used to treat bedwetting in children 6 years and older. Tofranil and Tofranil-PM are similar drugs also used to treat the symptoms of depression.

What form(s) does Imipramine Pamoate come in

  • Capsule

  • Tablet

What are common Imipramine Pamoate doses?

  • Capsule 75MG

  • Capsule 100MG

  • Capsule 125MG

  • Capsule 150MG

Common Imipramine Pamoate prescriptions

  • Imipramine Pamoate
    100mg capsule

  • Imipramine Pamoate
    125mg capsule

  • Imipramine Pamoate
    150mg capsule

  • Imipramine Pamoate
    75mg capsule

How to take Imipramine Pamoate

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. It may take 2 to 3 weeks before you start to feel better.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. It may take 2 to 3 weeks before you start to feel better.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

What to do if you miss a dose of Imipramine Pamoate

Imipramine Pamoate contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to imipramine or a similar medicine, or you had a recent heart attack.

Imipramine Pamoate warnings

  • This medicine may raise or lower your blood sugar level.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney or liver disease, glaucoma, heart or blood vessel disease, heart rhythm problems, trouble urinating, thyroid problems, or a history of schizophrenia or seizures.

  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.

  • This medicine may cause a serious reaction called serotonin syndrome, which can be life-threatening.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Imipramine Pamoate interactions

  • Do not use this medicine and an MAO inhibitor (MAOI) within 14 days of each other.

  • Some foods and medicines can affect how imipramine works. Tell your doctor if you are using any of the following: Buspirone, cimetidine, clonidine, epinephrine, fentanyl, guanethidine, lithium, methylphenidate, norepinephrine, St John's wort, tramadol, or tryptophan supplementsA triptan medicine to treat migraine headaches, medicine for heart rhythm problems (quinidine, flecainide, propafenone), medicine to lower blood pressure, medicine to treat seizures (phenobarbital, phenytoin), or a phenothiazine medicine (such as chlorpromazine, perphenazine, promethazine, prochlorperazine, thioridazine)

  • Tell your doctor if you are also using other medicine to treat depression, such as fluoxetine, paroxetine, or sertraline. You may need to wait at least 5 weeks before you begin using imipramine.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • This medicine may raise or lower your blood sugar level.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Imipramine Pamoate side effects

Serious Side Effects

  • Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there

  • Fever, sore throat, cough, chills

  • Eye pain, vision changes, seeing halos around lights

  • Thoughts of hurting yourself or others, trouble sleeping, unusual behavior

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Agitation, irritability, sudden increase in energy, trouble sleeping

  • Fast, pounding, or uneven heartbeat

Less Serious Side Effects

  • Dry mouth, constipation

  • Tiredness

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