What is Ipratropium-Albuterol: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Ipratropium-Albuterol overview

BRAND NAMES:

  • Combivent Respimat, Combivent Respimat, Duoneb

Generic Names:

  • Ipratropium-Albuterol

Uses:

  • Treats chronic obstructive pulmonary disease (COPD).

Therapeutic Classes:

  • Bronchodilator

Forms:

  • Powder Under Pressure, Solution, Spray

How it’s taken:

  • By breathing

What is Ipratropium-Albuterol used for?

Ipratropium-Albuterol is a prescription medicine that comes in the form of an inhalation solution. It is used to treat and prevent symptoms of ongoing lung disease such as wheezing and shortness of breath. Ipratropium-Albuterol works by relaxing muscles and opening up airways in the lungs to allow ease in breathing.

What form(s) does Ipratropium-Albuterol come in

  • Powder Under Pressure

  • Solution

  • Spray

What are common Ipratropium-Albuterol doses?

  • Plas Cont 3ML of 0.5-2.5 (3)MG/3ML

Common Ipratropium-Albuterol prescriptions

  • Ipratropium-Albuterol
    0.5-2.5 (3)mg/3ml, 30 vials inh soln 0.017-0.083% carton

  • Ipratropium-Albuterol
    0.5-2.5 (3)mg/3ml, 60 vials inh soln 0.017-0.083% carton

  • Ipratropium-Albuterol
    3ml of 0.5-2.5 (3)mg/3ml inhalation vial for nebulizer

  • Ipratropium-Albuterol
    3ml of 0.5-2.5 (3)mg/3ml plas cont

  • Ipratropium-Albuterol
    3ml of 0.5-2.5 (3)mg/3ml vial

How to take Ipratropium-Albuterol

  • Inhalation routeStore the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep this medicine inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

  • Inhalation routeKeep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Your doctor will tell you how much medicine to use. Do not use more than directed. This medicine comes in more than one form. Make sure you understand how to use your medicine. Ask your doctor or pharmacist if you have questions.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Aerosol inhaler: Inhalation routeYou will use this medicine with a device called a metered-dose inhaler. The inhaler fits on the medicine canister and turns the medicine into a fine spray that you breathe in through your mouth and to your lungs. You may be told to use a spacer, which is a tube that is placed between the inhaler and your mouth. Your caregiver will show you how to use your inhaler and the spacer (if needed). The first time you use a canister, shake it well for 10 seconds. Then spray the medicine 3 times away from your face. The medicine is now ready to use.Shake the canister well for 10 seconds each time before you use a dose. If you have not used the medicine in 24 hours, repeat the steps for the first use.Inhalation routeClean the inhaler mouthpiece daily with warm water.

  • Spray inhaler: You need to prime the spray inhaler the first time you use it and if you have not used it for more than 3 days in a row.To prime the spray inhaler, point the inhaler away from your face and press the button until some medicine sprays out. Then spray the medicine 3 more times. The medicine is now ready to use.Follow the instructions that came with the medicine if it has been more than 3 days since you used the medicine.Clean the mouthpiece with a damp cloth or a tissue. Do this at least once a week.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Aerosol inhaler: Inhalation routeYou will use this medicine with a device called a metered-dose inhaler. The inhaler fits on the medicine canister and turns the medicine into a fine spray that you breathe in through your mouth and to your lungs. You may be told to use a spacer, which is a tube that is placed between the inhaler and your mouth. Your caregiver will show you how to use your inhaler and the spacer (if needed). The first time you use a canister, shake it well for 10 seconds. Then spray the medicine 3 times away from your face. The medicine is now ready to use.Shake the canister well for 10 seconds each time before you use a dose. If you have not used the medicine in 24 hours, repeat the steps for the first use.Inhalation routeClean the inhaler mouthpiece daily with warm water.

  • Inhalation routeKeep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

  • Inhalation routeStore the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep this medicine inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

  • Spray inhaler: You need to prime the spray inhaler the first time you use it and if you have not used it for more than 3 days in a row.To prime the spray inhaler, point the inhaler away from your face and press the button until some medicine sprays out. Then spray the medicine 3 more times. The medicine is now ready to use.Follow the instructions that came with the medicine if it has been more than 3 days since you used the medicine.Clean the mouthpiece with a damp cloth or a tissue. Do this at least once a week.

  • Your doctor will tell you how much medicine to use. Do not use more than directed. This medicine comes in more than one form. Make sure you understand how to use your medicine. Ask your doctor or pharmacist if you have questions.

What to do if you miss a dose of Ipratropium-Albuterol

Ipratropium-Albuterol contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to albuterol, ipratropium, levalbuterol, or atropine. Do not use Combivent® if you are allergic to soya lecithin, soybeans, or peanuts.

Ipratropium-Albuterol warnings

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • This medicine may cause dizziness, drowsiness, or trouble seeing. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • If any of your COPD medicines do not seem to be working as well as usual, call your doctor right away. Take all of your COPD medicines as instructed. Do not use more medicine or change your dose without asking your doctor.

  • Do not use this medicine for a sudden COPD attack. Make sure you always have your rescue medicine with you to treat sudden symptoms.

  • This medicine may cause the following problems:Paradoxical bronchospasm (trouble breathing), which can be life-threateningHeart rhythm changes

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, diabetes, blood vessel problems, glaucoma, heart disease, heart rhythm problems, high blood pressure, an overactive thyroid, prostate problems, trouble urinating, or a history of seizures.

Ipratropium-Albuterol interactions

  • Do not use this medicine for a sudden COPD attack. Make sure you always have your rescue medicine with you to treat sudden symptoms.

  • If any of your COPD medicines do not seem to be working as well as usual, call your doctor right away. Take all of your COPD medicines as instructed. Do not use more medicine or change your dose without asking your doctor.

  • This medicine may cause dizziness, drowsiness, or trouble seeing. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • This medicine may cause the following problems:Paradoxical bronchospasm (trouble breathing), which can be life-threateningHeart rhythm changes

  • Some medicines can affect how ipratropium/albuterol works. Tell your doctor if you are using any of the following:Other inhaled medicinesBeta-blocker medicineDiuretic (water pills)Medicine to treat depression or an MAO inhibitor within the past 2 weeks

Ipratropium-Albuterol side effects

Serious Side Effects

  • Decrease in how much or how often you urinate, painful or difficult urination

  • Blurred vision, eye pain, seeing halos around objects

  • Dry mouth, increased thirst, muscle cramps, nausea, vomiting

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Chest pain, fast, pounding, or uneven heartbeat

  • Increased trouble breathing

Less Serious Side Effects

  • Nervousness, shaking

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