What is Isibloom? Uses, warnings & side effects

Read and follow the instructions printed on the package insert.

Take Isibloom tablets at the same time every day. 

Take one tablet per day. Do not miss a dose.

There are 21 orange tablets containing hormones and seven inert green tablets. Take all tablets, including the inert tablets.

Take the first tablet (number 1) on the day your period starts or the first Sunday after your period starts. 

When switching from another type of hormonal birth control, take the first pill the day you would have started a new blister pack, replaced a vaginal ring or patch, or the day an implant or IUD is removed.

Each tablet has a number assigned to it on the blister pack. Take each tablet in order.

Take the first orange pill from a new pack the day after the last green pill is taken from the old pack. 

Take the first pill of each new pack on the same day of the week each cycle.

Swallow the tablet whole with a drink of water.

• Do not crush, break, or chew it.

• Tablets can be taken without regard to food. 

If you vomit or have diarrhea, use backup birth control until you can talk to the prescriber. 

Store Isibloom at room temperature in the original carton.

Do not forget to take an Isibloom dose. Pregnancy is more likely when doses are missed.

• In addition to taking missed doses, it may be necessary to use backup birth control for at least seven days if a dose is missed.

If an orange pill is missed:

• Take it as soon as possible. 

• Take the next tablet at its regular time.

• Two doses can be taken on the same day to make up for a missed dose. 

• Pregnancy is not a risk if just one pill is missed. Backup birth control is not necessary.

If you miss two orange pills in a row in the first two weeks:

• Take two doses on the day you remember and two doses the next day.

• Return to the regular dosing schedule.

• Two consecutive missed doses increase the risk of pregnancy. Use backup birth control for at least seven days.

If you miss two orange pills in a row in the third week: 

• Start over with a new Isibloom kit.

• Day 1 starters should throw out the current pill pack and start with a new one.

• Sunday starters should continue to take orange pills from the old pack and then start a new pack on Sunday.

• You can get pregnant in the first seven days of starting a new kit. Use backup birth control.

If you miss three or more orange pills in a row in any week:

• Start over with a new Isibloom kit. 

• Day 1 starters should throw out the current pack and start with a new one.

• Sunday starters should continue to take orange pills from the old kit and then start a new one on Sunday.

• You can get pregnant in the first seven days of starting a new kit. Use backup birth control.

If you’re not sure about a missed pill, use backup birth control.

Some women should not use Isibloom. 

Do not use Isibloom if you are pregnant, older than 35, and smoke, or have:

• Unusual vaginal bleeding that has not been checked by a healthcare provider

• A history of heart attack or stroke

• A history of blood clots in the deep veins of the legs

• Current blood clots in the legs, lungs, or eyes

• Chest pain

• Persistently high blood pressure

• Current or past cerebral vascular or coronary artery disease

• Valvular heart disease with complications

• Diabetes with blood vessel problems

• Headaches with focal neurological symptoms

• Breast cancer

• Cancer of the lining of the uterus, the cervix, or the vagina

• A history of jaundice associated with pregnancy or birth control pills

• Liver tumor

• Major surgery involving prolonged bed rest

Tell any doctor or other healthcare provider who treats you that you are using this medicine, especially before a medical or dental procedure. 

• Oral contraceptives can interfere with several important blood tests. 

Your healthcare provider may need to do lab tests to check on the effects of this medicine. Keep all appointments.

Immediately tell the prescriber if you become pregnant, think you’re pregnant, or miss two periods in a row. 

Tell the healthcare provider if you smoke. 

Before starting Isibloom, tell the prescriber if you smoke, are breastfeeding, or have:

• Recently given birth

• Heart or blood vessel disease

• High blood pressure

• Elevated cholesterol or triglyceride levels

• Diabetes

• Migraines

• Depression

• Breast nodules

• Fibrocystic disease of the breasts

• An abnormal mammogram or breast X-ray

• Liver disease

• Gallbladder disease

• Kidney disease

• A history of light periods

This medicine may cause serious medical problems, including:

• Increased risk of blood clots, heart attack, and stroke

• Increased risk of breast or cervical cancer

• Liver problems

• Gallbladder problems

• High blood pressure

• High cholesterol

• Severe, persistent, or worsening headaches

• Increased risk of ectopic pregnancy

Isibloom can cause a spotty darkening of the skin, particularly on the face.

Isibloom should not be used four weeks before or two weeks after major surgery.

Women wearing contact lenses should immediately talk to the prescriber if they experience vision changes or are unable to wear the lenses. Isibloom can change the curvature of the cornea.

This medicine will not protect you from HIV/AIDS or other sexually transmitted diseases.

Do not take Isibloom with any hepatitis C drug containing ombitasvir/paritaprevir/ritonavir.

To avoid drug interactions, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medicines, and supplements regularly used before taking Isibloom, especially:

• Other birth control pills

• Barbiturates

• Macrolide antibiotics

• Drugs that treat fungal infections 

• Anticonvulsants

• Antiviral drugs that treat hepatitis C or HIV/AIDS

• Thyroid hormones

• St. John’s wort

• Acetaminophen, aprepitant, ascorbic acid, atorvastatin, bosentan, clofibric acid, cyclosporine, felbamate, prednisolone, rifabutin, rifampicin, rosuvastatin, rufinamide, theophylline, tizanidine

Avoid grapefruit and grapefruit juice when taking Isibloom.

Women taking colesevelam should take Isibloom four hours before or four hours after a colesevelam dose. 

Tell other healthcare providers you are using this medicine before they prescribe new medications.